PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3323072-6	1987	While therapy with metoprolol resulted in an increase of noradrenaline and a fall of plasma renin activity after 8 weeks, these parameters remained unchanged in I and III.	Metoprolol	19-29	renin	Homo sapiens	92-97	
3144329-13	1988	Plasma renin activity was low in both groups after metoprolol treatment, but change in blood pressure could not be predicted from baseline plasma renin activity.	Metoprolol	51-61	renin	Homo sapiens	7-12	
3281620-4	1988	We hypothesized that black patients with uncontrolled hypertension and low plasma renin activity on usual-dose hydrochlorothiazide therapy (ie, 50 mg/d) would respond better to higher doses of hydrochlorothiazide (ie, 100 to 150 mg/d) than to a usual-dose diuretic and metoprolol.	Metoprolol	269-279	renin	Homo sapiens	82-87	
3327678-4	1987	The felodipine-induced increase of plasma renin activity (100%; p less than 0.001) was completely reversed by metoprolol.	Metoprolol	110-120	renin	Homo sapiens	42-47	
2441175-9	1987	Acebutolol caused less attenuation of blood glucose and plasma lactate, and metoprolol less attenuation of plasma renin activity, than propranolol.	Metoprolol	76-86	renin	Homo sapiens	114-119	
3582471-8	1987	The felodipine-induced rise in plasma renin activity (PRA) of 100% was completely reversed by metoprolol.	Metoprolol	94-104	renin	Homo sapiens	38-43	
3023226-6	1986	The administration of a beta 1-adrenergic blocker, metoprolol (120 mg/day for 14 days), produced a significant (P less than 0.05 to P less than 0.01) fall in levels of T4, PRA and TRC, and reduced the active renin ratio calculated from PRC/TRC significantly (P less than 0.025), as compared to the pretreatment values.	Metoprolol	51-61	renin	Homo sapiens	208-213	
498696-0	1979	Effects of metoprolol on blood pressure and plasma renin activity in thiazide-resistant hypertensive patients.	Metoprolol	11-21	renin	Homo sapiens	51-56	
6356082-0	1983	[Plasma renin activity and urinary excretion of catecholamines and their metabolites in patients with primary arterial hypertension treated with metoprolol].	Metoprolol	145-155	renin	Homo sapiens	8-13	
6120716-3	1982	3 Large intravenous doses of propranolol or metoprolol attenuated, without abolishing, the rises in active renin, angiotensin II, and aldosterone; the attenuation was most evident soon after tilting and was largely overcome by 1 h upright.	Metoprolol	44-54	renin	Homo sapiens	107-112	
6120716-6	1982	5 Intravenous propranolol or metoprolol attenuated, without abolishing, these early increases in the components of the renin-angiotensin-aldosterone system after frusemide.	Metoprolol	29-39	renin	Homo sapiens	119-124	
6120716-9	1982	8 Also in contrast to earlier work, we found attenuation by both intravenous propranolol and metoprolol of the immediate rise in renin after intravenous frusemide.	Metoprolol	93-103	renin	Homo sapiens	129-134	
2869848-6	1986	However, using a multiple regression analysis there was a highly significant correlation between the combination of the pretreatment values of active renin, prorenin and aldosterone and the reduction in diastolic pressure with both nadolol (p less than 0.001) and metoprolol (p less than 0.003).	Metoprolol	264-274	renin	Homo sapiens	150-155	
6367871-1	1984	Treatment of fifteen patients with essential hypertension over four weeks using the beta 1-adrenoceptor blocking agent, metoprolol, resulted in a decrease in 24 h urinary excretion of kallikrein and aldosterone along with a decrease in plasma renin activity.	Metoprolol	120-130	renin	Homo sapiens	243-248	
6367871-3	1984	A positive correlation was found between plasma renin activity and urinary excretion of kallikrein during the control period and after 2 weeks on metoprolol, supporting the assumption of a preserved link between the renin-angiotensin-aldosterone system and the renal excretion of kallikrein in these patients.	Metoprolol	146-156	renin	Homo sapiens	48-53	
6352273-0	1983	Effects of penbutolol and metoprolol on blood pressure, plasma catecholamines and renin activity in hypertensive patients.	Metoprolol	26-36	renin	Homo sapiens	82-87	
7027889-0	1981	Metoprolol in high renin hypertension.	Metoprolol	0-10	renin	Homo sapiens	19-24	
7027889-5	1981	In patients with essential hypertension who were treated with metoprolol, a significant positive correlation (r = 0.66, n = 10) was also found between the fall in blood pressure and the fall in plasma renin activity.	Metoprolol	62-72	renin	Homo sapiens	201-206	
7004735-6	1980	Plasma renin activity was suppressed by therapy with metoprolol.	Metoprolol	53-63	renin	Homo sapiens	7-12	
226572-0	1978	Effects of salbutamol and metoprolol on plasma renin activity and plasma potassium of normal subjects and of hypertensive patients.	Metoprolol	26-36	renin	Homo sapiens	47-52	
760750-1	1979	1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of "active" renin and angiotensin II together with an increase of "inactive" renin and unchanged "total" renin.	Metoprolol	34-44	renin	Homo sapiens	112-136	
760750-1	1979	1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of "active" renin and angiotensin II together with an increase of "inactive" renin and unchanged "total" renin.	Metoprolol	34-44	renin	Homo sapiens	112-117	
760750-1	1979	1 beta-adrenoceptor blockade with metoprolol provoked, both at rest and during exercise, a decrease of "active" renin and angiotensin II together with an increase of "inactive" renin and unchanged "total" renin.	Metoprolol	34-44	renin	Homo sapiens	177-182	
760750-2	1979	The significant exercise-provoked increases in angiotensin II, plasma renin activity and "active", "inactive" and "total" renin when on placebo, were reduced by metoprolol.	Metoprolol	161-171	renin	Homo sapiens	70-75	
760750-2	1979	The significant exercise-provoked increases in angiotensin II, plasma renin activity and "active", "inactive" and "total" renin when on placebo, were reduced by metoprolol.	Metoprolol	161-171	renin	Homo sapiens	122-127	
354827-14	1978	The plasma renin activity was significantly reduced in the metoprolol but not in the alpha-methyldopa group.	Metoprolol	59-69	renin	Homo sapiens	11-16	
7373-0	1976	Plasma levels and effects of metoprolol on blood pressure, adrenergic beta receptor blockade, and plasma renin activity in essential hypertension.	Metoprolol	29-39	renin	Homo sapiens	105-110	
1013675-4	1976	Metoprolol leads to a significant fall in renin and heart rate, whereas cardiac index is depressed only during exercise.	Metoprolol	0-10	renin	Homo sapiens	42-47	
1013675-7	1976	In comparison with propranolol the hemodynamic and renin patterns under metoprolol are similar, the only difference being the slighter fall in blood pressure due to a less depressed cardiac index.	Metoprolol	72-82	renin	Homo sapiens	51-56	
1071676-0	1976	Comparison of metoprolol and propranolol in modification of haemodynamic and renin-aldosterone responses to tilting in humans.	Metoprolol	14-24	renin	Homo sapiens	77-82	
1071676-8	1976	Metoprolol and propranolol both reduced the rise in plasma renin activity induced by tilting.	Metoprolol	0-10	renin	Homo sapiens	59-64	
16999659-3	2006	A recent study showed a better metabolic profile with carvedilol than with metoprolol in patients with both type 2 diabetes and hypertension in the presence of renin-angiotensin system blockade.	Metoprolol	75-85	renin	Homo sapiens	160-165	
1233219-0	1975	Effects of metoprolol and propranolol on furosemide-stimulated renin release in healthy subjects.	Metoprolol	11-21	renin	Homo sapiens	63-68	
1233219-1	1975	The effects of single doses of the beta1-receptor antagonist metoprolol (40 mg orally), propranolol (40 mg orally) and placebo were compared on furosemide-stimulated plasma renin activity (PRA) in seven healthy subjects.	Metoprolol	61-71	renin	Homo sapiens	173-178	
20102922-10	2010	With metoprolol, plasma B-type natriuretic peptide increased and plasma renin decreased.	Metoprolol	5-15	renin	Homo sapiens	72-77	
10653828-12	2000	CONCLUSIONS: When added to ACE inhibitors, angiotensin II receptor antagonists, or both, the use of metoprolol CR improves ventricular function, reduces activation of the renin-angiotensin systems, and results in fewer deaths.	Metoprolol	100-110	renin	Homo sapiens	171-176	
12914870-0	2003	Effect of beta blockade (carvedilol or metoprolol) on activation of the renin-angiotensin-aldosterone system and natriuretic peptides in chronic heart failure.	Metoprolol	39-49	renin	Homo sapiens	72-77	
1685199-2	1991	Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were markedly suppressed in the first episode occurring in paralell with the administration of metoprolol during piroxicam and lobenzarit (CCA) therapy.	Metoprolol	166-176	renin	Homo sapiens	7-12	
10088202-0	1998	Response of serum total renin to ramipril and metoprolol in hypertensive patients.	Metoprolol	46-56	renin	Homo sapiens	24-29	
10088202-9	1998	Ramipril significantly increased the mean value of total renin (191.9 ng/l vs 312.0 ng/l, p < 0.01), but the metoprolol-induced increase in the concentration of serum total renin was insignificant.	Metoprolol	112-122	renin	Homo sapiens	176-181	
10363743-0	1999	The circulating renin-angiotensin system during treatment with metoprolol or captopril in patients with heart failure due to non-ischaemic dilated cardiomyopathy.	Metoprolol	63-73	renin	Homo sapiens	16-21	
10363743-13	1999	CONCLUSION: In patients with dilated cardiomyopathy and only a partly activated renin-angiotensin system, both metoprolol and captopril reduced urinary excretion of aldosterone.	Metoprolol	111-121	renin	Homo sapiens	80-85