PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12781630-11	2003	Furthermore, like OX, the diclofenac-induced PLN reaction was attenuated in mice that had been orally pretreated three times with DF.	Diclofenac	26-36	phospholamban	Mus musculus	45-48	
11992736-4	2002	In BALB/c mice, diclofenac caused dose-dependent increases in PLN weight and PLN cellularity in the direct PLNA; 0.25 mg was non-immunostimulating whereas 0.50-1.00 mg caused a significant PLN reaction.	Diclofenac	16-26	phospholamban	Mus musculus	62-65	
11992736-4	2002	In BALB/c mice, diclofenac caused dose-dependent increases in PLN weight and PLN cellularity in the direct PLNA; 0.25 mg was non-immunostimulating whereas 0.50-1.00 mg caused a significant PLN reaction.	Diclofenac	16-26	phospholamban	Mus musculus	77-80	
11992736-4	2002	In BALB/c mice, diclofenac caused dose-dependent increases in PLN weight and PLN cellularity in the direct PLNA; 0.25 mg was non-immunostimulating whereas 0.50-1.00 mg caused a significant PLN reaction.	Diclofenac	16-26	phospholamban	Mus musculus	77-80	
11992736-5	2002	In the direct PLNA, diclofenac also increased the percent of T cells in the PLN with activated phenotypes (CD44(high)CD62L(low) and CD44(high)CD62L(high)).	Diclofenac	20-30	phospholamban	Mus musculus	14-17	
11992736-6	2002	Finally, the magnitude of the diclofenac-induced direct PLN reaction was significantly reduced when the assay was conducted in T-cell-deficient mice.	Diclofenac	30-40	phospholamban	Mus musculus	56-59	
11992736-7	2002	When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.	Diclofenac	87-97	phospholamban	Mus musculus	130-133	
11992736-7	2002	When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.	Diclofenac	87-97	phospholamban	Mus musculus	142-145	
11992736-7	2002	When co-injected with the reporter antigen TNP-Ficoll (trinitrophenyl Ficoll), 0.50 mg diclofenac caused significant increases in PLN weight, PLN cellularity, and induced IgM and IgG(1) anti-TNP antibody forming cells (AFCs) in the PLN.	Diclofenac	87-97	phospholamban	Mus musculus	142-145	
11992736-11	2002	Likewise, diclofenac caused dose-dependent increases (0.25-1.00 mg) in PLN cellularity and IgM AFCs.	Diclofenac	10-20	phospholamban	Mus musculus	71-74	
11992736-13	2002	Finally, an increase in the intracellular level of IL-4, but not INFgamma, was detected in CD4(+) PLN cells following the injection of diclofenac mixed with TNP-OVA.	Diclofenac	135-145	phospholamban	Mus musculus	98-101	
11992736-14	2002	Collectively, these data suggest that diclofenac: (i) induces a T-cell-dependent direct PLN reaction that; (ii) provides non-cognate help for IgG AFC production when co-injected with TNP-Ficoll, possibly through the formation of neo-antigens; and (iii) possesses intrinsic adjuvant activity that selectively induces IL-4 mediated production of IgG(1) and IgE against co-injected TNP-OVA.	Diclofenac	38-48	phospholamban	Mus musculus	88-91