PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34422219-3 2021 The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions. Diclofenac 50-60 tumor necrosis factor Rattus norvegicus 169-178 33933169-9 2021 RESULTS: Addition of neostigmine to selective or non-selective NSAIDs (celecoxib or diclofenac) causes an increased level of analgesia of NSAIDs with rapid onset of action and short duration, while causing potentiation of the anti-inflammatory effect of neostigmine as seen in the tail clip, writhing, formalin test, Cox-1 and Cox-2 activities, serum beta-endorphin, TNF-alpha, NF-kB and HS-CRP. Diclofenac 84-94 tumor necrosis factor Rattus norvegicus 367-376 35509154-4 2022 Rutin significantly attenuated diclofenac-induced alterations in the serum cardiac markers (LDH, CK-MB, and SGOT), serum cytokine levels (TNF-alpha and IL-6), and oxidative stress markers (MDA and GSH) in the cardiac tissue. Diclofenac 31-41 tumor necrosis factor Rattus norvegicus 138-147 28535741-9 2017 In group 2, diclofenac caused a significant increase (p < .05) in the levels of serum ALP, GOT, GPT, TNF-alpha, uric acid, protein carbonyl content, MDA, and liver TNF-alpha gene expression as opposed to group 1. Diclofenac 12-22 tumor necrosis factor Rattus norvegicus 104-113 32010892-6 2019 Significantly decreased serum levels of inflammatory biomarkers including TNF-alpha, IL-1beta, and IL-6 were observed in rats treated with high-dose oral NCL or intramuscular injection of diclofenac sodium, compared with groups B and C. Histopathological examination revealed that a high dose of NCL significantly reduced the infiltration of inflammatory cells, synovial hyperplasia, and bone and cartilage destruction. Diclofenac 188-205 tumor necrosis factor Rattus norvegicus 74-83 33386491-11 2021 The serum concentration of TNF-alpha and PGE2 was remarkably (p < 0.01-< 0.0001) restored by the DS and MBME dose dependently. Diclofenac 97-99 tumor necrosis factor Rattus norvegicus 27-36 28795275-8 2017 Our results demonstrated that PBMT, 1 J (35.7 J/cm2), 3 J (107.1 J/cm2), and 9 J (321.4 J/cm2) reduced the expression of tumor necrosis factor alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) genes at all assessed times as compared to the injury and diclofenac groups (p < 0.05). Diclofenac 248-258 tumor necrosis factor Rattus norvegicus 121-148 28795275-8 2017 Our results demonstrated that PBMT, 1 J (35.7 J/cm2), 3 J (107.1 J/cm2), and 9 J (321.4 J/cm2) reduced the expression of tumor necrosis factor alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) genes at all assessed times as compared to the injury and diclofenac groups (p < 0.05). Diclofenac 248-258 tumor necrosis factor Rattus norvegicus 150-159 28535741-9 2017 In group 2, diclofenac caused a significant increase (p < .05) in the levels of serum ALP, GOT, GPT, TNF-alpha, uric acid, protein carbonyl content, MDA, and liver TNF-alpha gene expression as opposed to group 1. Diclofenac 12-22 tumor necrosis factor Rattus norvegicus 167-176 28535741-11 2017 This study confirmed the protective effect of NAC on diclofenac-induced hepatotoxicity in rats due to not only reduces liver inflammatory cells, TNF-alpha, serum MDA, and PC but also through increases liver vitamin C, catalase, and superoxide dismutase activities. Diclofenac 53-63 tumor necrosis factor Rattus norvegicus 145-154 22619518-10 2012 Concerning tumor necrosis factor alpha, only the group treated with the association diclofenac and GNPs presented decreased levels, compared with the control (3.221 +- 369) (P < 0.05). Diclofenac 84-94 tumor necrosis factor Rattus norvegicus 11-38 28535741-0 2017 Effects of N-acetyl cysteine on oxidative stress and TNF-alpha gene expression in diclofenac-induced hepatotoxicity in rats. Diclofenac 82-92 tumor necrosis factor Rattus norvegicus 53-62 9875706-3 1998 The TNFalpha-induced SWS enhancement, fever and anorexia were all blocked by co-infusion of diclofenac, a non-selective cyclooxygenase (COX) inhibitor, and by pretreatment with NS-398, a COX-2-specific inhibitor. Diclofenac 92-102 tumor necrosis factor Rattus norvegicus 4-12 22007590-9 2011 CONCLUSION: Acupuncture can down-regulate the expression of IL-1beta and TNF-alpha in osteoarthritic chondrocytes, and the regulating effect is the same as Diclofenac. Diclofenac 156-166 tumor necrosis factor Rattus norvegicus 73-82 17241876-9 2007 Diclofenac, but not ATB-337, elevated gastric granulocyte infiltration and expression of tumor necrosis factor alpha, lymphocyte function-associated antigen 1, and intercellular adhesion molecule 1. Diclofenac 0-10 tumor necrosis factor Rattus norvegicus 89-116 21087170-11 2011 Both AEP and diclofenac were equipotent in reducing the level of TNF-alpha and were able to normalize NO and the oxidative stress biomarkers in non-irradiated and irradiated arthritic rats. Diclofenac 13-23 tumor necrosis factor Rattus norvegicus 65-74 20980538-7 2011 Injection of diclofenac partially reversed the TNFalpha-induced decreases in the mechanical threshold (MT) of masseter muscle nociceptors, whereas vehicle control, APV, and TrkA antibody did not significantly alter nociceptor MT. Diclofenac 13-23 tumor necrosis factor Rattus norvegicus 47-55 19798548-8 2009 In many respects, celecoxib (5 mg/kg) was as potent as diclofenac in decreasing the elevated levels of IL-6, IL-1beta, TNF-alpha, LTB(4), PGE(2), but lacked any significant effect on TXB(2) level. Diclofenac 55-65 tumor necrosis factor Rattus norvegicus 119-128 17291994-4 2007 S-diclofenac administration downregulated expression of genes encoding enzymes which synthesize nitric oxide, prostanoids, and H2S; reduced plasma IL-1beta/TNF-alpha; and elevated plasma IL-10. Diclofenac 2-12 tumor necrosis factor Rattus norvegicus 156-165 12570019-8 2002 Diclofenac also partially abolished the elevation in serum TNF-alpha levels, but at the highest dose only (3 mg/kg). Diclofenac 0-10 tumor necrosis factor Rattus norvegicus 59-68 8945729-4 1996 The TNF-alpha (10 pg)-induced reduction in paw withdrawal latency was blocked by simultaneous injection of diclofenac (1 ng), a cyclooxygenase inhibitor, or interleukin-1 receptor antagonist (IL-1 ra, 10 ng). Diclofenac 107-117 tumor necrosis factor Rattus norvegicus 4-13