PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32647537-11	2020	Conclusion: Diclofenac, which has been shown to have active transport into the central nervous system, and which has been shown to lower amyloid beta and interleukin 1 beta, is associated with a significantly lower frequency of AD compared with etodolac and naproxen.	Diclofenac	12-22	interleukin 1 beta	Homo sapiens	154-172	
8930329-0	1996	Inhibition of peripheral interleukin-1 beta-induced hyperalgesia by the intracerebroventricular administration of diclofenac and alpha-melanocyte-stimulating hormone.	Diclofenac	114-124	interleukin 1 beta	Homo sapiens	25-43	
10568060-4	1999	Application of diclofenac after abdominal hysterectomies reduced substantially intraperitoneal IL-1 beta levels.	Diclofenac	15-25	interleukin 1 beta	Homo sapiens	95-104	
10342040-14	1999	Furthermore, both nimesulide and diclofenac at therapeutic concentrations significantly decreased spontaneous and IL-1 beta-stimulated IL-6 production by human chondrocytes, but did not modify IL-8 production.	Diclofenac	33-43	interleukin 1 beta	Homo sapiens	114-123	
9297577-5	1997	RESULTS: RhIL-1 beta augments the production of TIMP-1 and proMMP-1 in synovial fibroblasts from RA patients, and this IL-1-induced production of TIMP-1 and proMMP-1 was further enhanced by treatment with the cyclooxygenase inhibitors, indomethacin and diclofenac.	Diclofenac	253-263	interleukin 1 beta	Homo sapiens	11-15	
9089670-8	1997	The inhibitory effect of hIL-1 beta was blocked by human recombinant IL-1 receptor antagonist (50 ng/ml), and by the cyclooxygenase inhibitor, diclofenac (1 mumol/l), suggesting that hIL-1 beta inhibited NA release through the formation of prostaglandins.	Diclofenac	143-153	interleukin 1 beta	Homo sapiens	25-35	
9089670-8	1997	The inhibitory effect of hIL-1 beta was blocked by human recombinant IL-1 receptor antagonist (50 ng/ml), and by the cyclooxygenase inhibitor, diclofenac (1 mumol/l), suggesting that hIL-1 beta inhibited NA release through the formation of prostaglandins.	Diclofenac	143-153	interleukin 1 beta	Homo sapiens	183-193	
14690293-2	2003	N-acetylcysteine and diclofenac were most effective in suppressing TNF-alpha and IL-1beta expression by the monocyte-macrophages.	Diclofenac	21-31	interleukin 1 beta	Homo sapiens	81-89	
11556519-8	2001	RESULTS: We have demonstrated that aceclofenac, 4"-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes.	Diclofenac	74-84	interleukin 1 beta	Homo sapiens	228-236	
8597883-1	1995	We performed an open, between patients, placebo controlled study in order to evaluate the effect of the treatment with the non steroidal anti inflammatory drugs indomethacin, diclofenac and naproxen on the concentrations of the cytokines IL-1 beta and IL-6 and of the neuropeptide substance P in plasma and synovial fluid of 24 rheumatoid arthritis patients.	Diclofenac	175-185	interleukin 1 beta	Homo sapiens	238-247