PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34788386-0	2022	Optimal fludarabine lymphodepletion is associated with improved outcomes following CAR T-cell Therapy.	fludarabine	8-19	nuclear receptor subfamily 1 group I member 3	Homo sapiens	83-86	
34788386-4	2022	We hypothesized that optimal fludarabine exposure in lymphodepleting chemotherapy prior to CAR T-cell therapy would improve outcomes.	fludarabine	29-40	nuclear receptor subfamily 1 group I member 3	Homo sapiens	91-94	
34788386-5	2022	In a retrospective analysis of relapsed/refractory B-cell acute lymphoblastic leukemia patients undergoing CAR T-cell (tisagenlecleucel) infusion after cyclophosphamide/fludarabine lymphodepleting chemotherapy, we estimated the fludarabine exposure as area-under-the-curve (AUC;mg*hr/L) using a validated population-pharmacokinetic model.	fludarabine	228-239	nuclear receptor subfamily 1 group I member 3	Homo sapiens	107-110	
34788386-11	2022	Personalized PK-directed dosing to achieve optimal fludarabine exposure should be tested in prospective trials and based on this analysis may reduce disease relapse after CAR T-cell therapy.	fludarabine	51-62	nuclear receptor subfamily 1 group I member 3	Homo sapiens	171-174	
31626107-13	2019	sCRS was associated with a high dose of infused CAR T cells when IL-2 and fludarabine were excluded from the positive factors for sCRS.	fludarabine	74-85	nuclear receptor subfamily 1 group I member 3	Homo sapiens	48-51	
27605551-3	2016	Patients who received Cy/Flu lymphodepletion had increased CAR-T cell expansion and persistence, and higher response rates [50% complete remission (CR), 72% overall response rate (ORR)] than patients who received Cy-based lymphodepletion without Flu (8% CR, 50% ORR).	fludarabine	25-28	nuclear receptor subfamily 1 group I member 3	Homo sapiens	59-62	
29749441-4	2018	The second aim was to evaluate the abilities of fludarabine (FDR) and mafosfamide (MFA; a metabolite of cyclophosphamide) to induce apoptosis of CD19-CAR-T cells via the use of Annexin V/propidium iodide double staining.	fludarabine	48-59	nuclear receptor subfamily 1 group I member 3	Homo sapiens	150-153	
27111235-8	2016	Addition of fludarabine to the lymphodepletion regimen improved CAR-T cell persistence and disease-free survival.	fludarabine	12-23	nuclear receptor subfamily 1 group I member 3	Homo sapiens	64-67