PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25111583-8 2014 The interactions of PUMA with MCL-1 and/or BCL-2 were enhanced when cells were exposed to Bu+Clo+Flu or Bu+Clo+Flu+Sor. fludarabine 97-100 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 30-35 25804768-4 2015 MEKi-1 down-regulated the activities of AKT and ERK1/2 and was synergistic with fludarabine through a mechanism that involved potentiation of DNA damage and attenuation of the activity of ERK1/2 and expression of Mcl-1. fludarabine 80-91 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 213-218 25111583-8 2014 The interactions of PUMA with MCL-1 and/or BCL-2 were enhanced when cells were exposed to Bu+Clo+Flu or Bu+Clo+Flu+Sor. fludarabine 111-114 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 30-35 24495868-6 2014 The Mechanism of synergy was associated with CDKI-73-mediated transcriptional inhibition of MCL1 and XIAP that was maintained when used in combination with fludarabine. fludarabine 156-167 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 92-96 24141622-3 2013 In the present study, we found that the combination of fludarabine and VPA decreases the level of the anti-apoptotic proteins Mcl-1 and XIAP in primary CLL cells. fludarabine 55-66 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 126-131 22128299-10 2012 Interestingly, increasing the Noxa/Mcl-1 ratio, by decreasing Mcl-1 (dasatinib and roscovitine) or increasing Noxa levels (fludarabine and bortezomib), resulted in synergy with ABT-737. fludarabine 123-134 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 35-40 22072733-5 2012 RESULTS: Resistance to fludarabine-mediated apoptosis was induced by CD40 activation alone stimulating high levels of BCL-XL and MCL1 protein expression. fludarabine 23-34 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 129-133 23681223-0 2013 BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells. fludarabine 48-59 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 32-37 22619113-7 2012 In contrast, fludarabine significantly induced the transcription of MCL1 and BIRC5. fludarabine 13-24 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 68-72 18599795-5 2008 In addition, Mcl-1 and Mcl-1/Bax ratios showed strong correlations with in vitro resistance to fludarabine (P = .005 and P < .001, respectively). fludarabine 95-106 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 13-18 20335218-7 2010 In combination with fludarabine, the SYK inhibitor R406 abrogated stroma-mediated drug resistance by preventing up-regulation of the antiapoptotic factor Mcl-1 in CLL cells. fludarabine 20-31 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 154-159 21750559-6 2011 RESULTS: B cells isolated from CLL patients showed different levels of Mcl-1 protein expression, resulting, in several cases, in increased sensitivity to fludarabine. fludarabine 154-165 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 71-76 19762485-7 2009 Furthermore, MSCs maintained Mcl-1 and protected CLL cells from spontaneous and fludarabine-induced Mcl-1 and PARP cleavage. fludarabine 80-91 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 100-105 19008456-2 2009 Increased Mcl-1 expression is associated with failure to achieve remission after treatment with fludarabine and chlorambucil in patients with chronic lymphocytic leukemia (CLL). fludarabine 96-107 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 10-15 18836097-5 2009 Stromal cells protected CLL B cells from spontaneous and fludarabine-induced apoptosis (P = .003) by increasing the Mcl-1 protein levels. fludarabine 57-68 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 116-121 18599795-5 2008 In addition, Mcl-1 and Mcl-1/Bax ratios showed strong correlations with in vitro resistance to fludarabine (P = .005 and P < .001, respectively). fludarabine 95-106 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 23-28 11472347-5 2001 Bcl-2 and Mcl-1 expression were downregulated in both flavopiridol and fludarabine-induced apoptotic cells, but the increase in Bax expression that accompanied fludarabine-induced apoptosis was not evident in flavopiridol-treated cells. fludarabine 71-82 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 10-15 16501812-0 2006 Fludarabine induces apoptosis in chronic lymphocytic leukemia--the role of P53, Bcl-2, Bax, Mcl-1, and Bag-1 proteins. fludarabine 0-11 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 92-97 15059916-5 2004 Potentiation of fludarabine lethality by MS-275 was associated with acetylation of histones H3 and H4, down-regulation of the antiapoptotic proteins XIAP and Mcl-1, enhanced cytosolic release of proapoptotic mitochondrial proteins (e.g., cytochrome c, Smac/DIABLO, and apoptosis-inducing factor), and caspase activation. fludarabine 16-27 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 158-163 17018621-6 2006 By simultaneously triggering production of NOXA (using bortezomib) as well as reducing Mcl-1 levels (using siRNA, UV light, or fludarabine), significantly enhanced killing of melanoma cells was achieved. fludarabine 127-138 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 87-92 16501812-6 2006 Mcl-1 expression was increased in fludarabine-resistant cells and seemed to be a remarkable protein for the inhibition of the apoptotic process in CLL (from 233.59 +/- 29.8 to 252.04 +/- 35.5; P = 0.033). fludarabine 34-45 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 0-5 9558396-5 1998 Higher levels of the anti-apoptotic protein Mcl-1 were strongly correlated with failure to achieve complete remission (CR) after single-agent therapy (fludarabine or chlorambucil) (P = .001), but the presence of only seven CRs among the 42 patients for whom follow-up data were available necessitates cautious interpretation of these observations. fludarabine 151-162 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 44-49 34319043-11 2021 CONCLUSIONS: Our data propose that suppression of Bcl-2 and Mcl-1 by miRNA-15a can effectively inhibit the cell proliferation and sensitize CLL cells to fludarabine. fludarabine 153-164 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 60-65 34319043-0 2021 MiRNA-Mediated Knock-Down of Bcl-2 and Mcl-1 Increases Fludarabine-Sensitivity in CLL-CII Cells. fludarabine 55-66 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 39-44 34319043-1 2021 BACKGROUND: Over-expression of anti-apoptotic proteins such as Bcl-2 and Mcl-1 is associated with resistance to chemotherapeutic agents such as fludarabine. fludarabine 144-155 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 73-78 35154579-8 2022 ABT199/venetocalx upregulated anti-apoptotic MCL1 as a compensatory mechanism but addition of (Bu+4HC) or (Bu+Flu) negated this effect by CASPASE 3-mediated cleavage of MEK1/2 and its substrate MCL1. fludarabine 110-113 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 194-198