PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26079827-6	2015	Cells with decreased cN-II expression were resistant to the nucleoside analog fludarabine confirming the involvement of cN-II in the metabolism of this drug.	fludarabine	78-89	5'-nucleotidase, cytosolic II	Homo sapiens	21-26	
25857773-2	2015	Recently, a number of papers demonstrated the involvement of cN-II in the mechanisms of resistance to antitumor drugs such as cytarabine, gemcitabine and fludarabine.	fludarabine	154-165	5'-nucleotidase, cytosolic II	Homo sapiens	61-66	
25857773-12	2015	SENTENCE: Resistance to fludarabine, gemcitabine and cytarabine can be determined by an increase of cN-II both through dephosphorylation of active drugs and perturbation of nucleotide pool.	fludarabine	24-35	5'-nucleotidase, cytosolic II	Homo sapiens	100-105	
25656700-0	2015	The purine analog fludarabine acts as a cytosolic 5"-nucleotidase II inhibitor.	fludarabine	18-29	5'-nucleotidase, cytosolic II	Homo sapiens	40-68	
25656700-3	2015	In this paper we present evidence showing that, among the commonly used cytotoxic nucleoside analogs, fludarabine can act as a cN-II inhibitor.	fludarabine	102-113	5'-nucleotidase, cytosolic II	Homo sapiens	127-132	
25656700-4	2015	In vitro studies using the wild type recombinant cN-II demonstrated that fludarabine inhibited enzymatic activity in a mixed manner (Ki 0.5 mM and Ki" 9 mM), whereas no inhibition was observed with clofarabine and cladribine.	fludarabine	73-84	5'-nucleotidase, cytosolic II	Homo sapiens	49-54	
25656700-7	2015	This is in line with the hypothesis that fludarabine acts as a cN-II inhibitor and supports the idea of using cN-II inhibitors in association with other drugs to increase their therapeutic effect and decrease their resistance.	fludarabine	41-52	5'-nucleotidase, cytosolic II	Homo sapiens	63-68	
25656700-7	2015	This is in line with the hypothesis that fludarabine acts as a cN-II inhibitor and supports the idea of using cN-II inhibitors in association with other drugs to increase their therapeutic effect and decrease their resistance.	fludarabine	41-52	5'-nucleotidase, cytosolic II	Homo sapiens	110-115	
16629121-3	2006	We have investigated the dephosphorylation of monophosphorylated fludarabine (F-ara-AMP) by the purified cytoplasmic 5"-nucleotidase cN-II using HPLC and NMR.	fludarabine	65-76	5'-nucleotidase, cytosolic II	Homo sapiens	133-138	
16629121-4	2006	These studies clearly showed that cN-II was able to convert F-ara-AMP into its non phosphorylated form, F-ara-A, with a Km in the millimolar range and Vmax = 35 nmol/min/mg, with both methods.	fludarabine	60-67	5'-nucleotidase, cytosolic II	Homo sapiens	34-39