PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20307198-0	2010	Combination of fludarabine and imatinib induces apoptosis synergistically through loss of mitochondrial membrane potential and increases in caspase-3 enzyme activity in human K562 chronic myleloid leukemia cells.	fludarabine	15-26	caspase 3	Homo sapiens	140-149	
23595697-9	2013	Fludarabine treatment also enhanced caspase-3/7 activity in HEC1A relative to HEC50B cells (p < 0.001), and inhibited the growth of HEC1A xenograft tumors relative to cisplatin (p < 0.05).	fludarabine	0-11	caspase 3	Homo sapiens	36-45	
26165829-7	2015	To some extent, caspase-3 activation may be involved in the mechanism of the ZGDHu-1 synergistic cytotoxic effect with fludarabine, as well as the cleavage of PARP, consequently leading to apoptosis.	fludarabine	119-130	caspase 3	Homo sapiens	16-25	
21223714-8	2010	Apoptotic cells of RPMI8226 and KM3 increased in a dose- dependent manner after exposure to fludarabine for 24 h. Western blot analysis showed the activation of caspase-3 and PARP in the MM cells treated with fludarabine.	fludarabine	92-103	caspase 3	Homo sapiens	161-170	
21223714-8	2010	Apoptotic cells of RPMI8226 and KM3 increased in a dose- dependent manner after exposure to fludarabine for 24 h. Western blot analysis showed the activation of caspase-3 and PARP in the MM cells treated with fludarabine.	fludarabine	209-220	caspase 3	Homo sapiens	161-170	
20001234-5	2010	Consistent with the viability assay, we found an increased caspase-3 activity together with activation of caspase-9 in B-CLL cells sensitive to sequential non-cytotoxic fludarabine and rituximab exposure.	fludarabine	169-180	caspase 3	Homo sapiens	59-68	
20001234-6	2010	Non-cytotoxic fludarabine concentrations may sensitize B-CLL cells to rituximab-mediated cytotoxicity via caspase-3 activation.	fludarabine	14-25	caspase 3	Homo sapiens	106-115	
14574328-7	2004	Our results also provide an insight into a new complementary proapoptotic action of F-ara in B-CLL by the induction of particular iNOS splice variants, leading to the activation of a caspase-3-dependent apoptotic pathway.	fludarabine	84-89	caspase 3	Homo sapiens	183-192	
11848518-14	2001	Quantitative measurement of activated caspase-3 (pg per million cells) showed the two drugs, cytarabine and fludarabine, significantly increased the activated caspase-3 level in KGI myeloid leukaemia cells.	fludarabine	108-119	caspase 3	Homo sapiens	38-47	
11848518-14	2001	Quantitative measurement of activated caspase-3 (pg per million cells) showed the two drugs, cytarabine and fludarabine, significantly increased the activated caspase-3 level in KGI myeloid leukaemia cells.	fludarabine	108-119	caspase 3	Homo sapiens	159-168	
11848518-15	2001	CONCLUSION: The addition of ajoene enhanced the activation of caspase-3 in both cytarabine- and fludarabine-treated KGI cells.	fludarabine	96-107	caspase 3	Homo sapiens	62-71	
11234887-2	2001	Simultaneous or subsequent exposure of F-ara-A-treated cells (2 microM) to UCN-01 (100 nM) resulted in a marked potentiation of apoptosis, manifested by loss of mitochondrial membrane potential (delta psi(m)), cleavage/activation of procaspase-9 and procaspase-3, DNA fragmentation, and degradation of poly-ADP(ribosyl) polymerase.	fludarabine	39-46	caspase 3	Homo sapiens	233-262	
35154579-8	2022	ABT199/venetocalx upregulated anti-apoptotic MCL1 as a compensatory mechanism but addition of (Bu+4HC) or (Bu+Flu) negated this effect by CASPASE 3-mediated cleavage of MEK1/2 and its substrate MCL1.	fludarabine	110-113	caspase 3	Homo sapiens	138-147	
10557065-10	1999	Caspase-3/CPP32 activity increase was registered after dexamethasone as well as after fludarabine treatment in CLL lymphocytes in vitro.	fludarabine	86-97	caspase 3	Homo sapiens	0-9	
10557065-10	1999	Caspase-3/CPP32 activity increase was registered after dexamethasone as well as after fludarabine treatment in CLL lymphocytes in vitro.	fludarabine	86-97	caspase 3	Homo sapiens	10-15