PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27835611-0 2016 Effect of cobalt-mediated Toll-like receptor 4 activation on inflammatory responses in endothelial cells. Cobalt 10-16 toll like receptor 4 Homo sapiens 26-46 31198997-3 2019 OBJECTIVES: To investigate whether this limitation of RhE might be attributable to a lack of functional expression of Toll-like receptor 4 (TLR4), which governs proinflammatory sensitivity to nickel and cobalt. Cobalt 203-209 toll like receptor 4 Homo sapiens 140-144 30326385-6 2019 The effect of nickel and cobalt - previously reported to activate the hTLR4/MD-2 complex - was found to be negligible in comparison to that of iron. Cobalt 25-31 toll like receptor 4 Homo sapiens 70-75 27467577-3 2016 Recently, specific non-conserved histidines on human TLR4 have been shown activated by cobalt and nickel ions in solution. Cobalt 87-93 toll like receptor 4 Homo sapiens 53-57 25803856-0 2015 MD-2 determinants of nickel and cobalt-mediated activation of human TLR4. Cobalt 32-38 toll like receptor 4 Homo sapiens 68-72 28955928-0 2016 Cobalt ions recruit inflammatory cells in vitro through human Toll-like receptor 4. Cobalt 0-6 toll like receptor 4 Homo sapiens 62-82 28955928-4 2016 Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2. Cobalt 38-44 toll like receptor 4 Homo sapiens 97-101 26840091-5 2016 Cobalt ions activate Toll-like receptor 4 (TLR4), an innate immune receptor responsible for inflammatory responses to bacterial lipopolysaccharide (LPS) resulting in the production of pro-inflammatory cytokines and chemokines. Cobalt 0-6 toll like receptor 4 Homo sapiens 21-41 26840091-5 2016 Cobalt ions activate Toll-like receptor 4 (TLR4), an innate immune receptor responsible for inflammatory responses to bacterial lipopolysaccharide (LPS) resulting in the production of pro-inflammatory cytokines and chemokines. Cobalt 0-6 toll like receptor 4 Homo sapiens 43-47 26840091-6 2016 We hypothesised that anti-TLR4 neutralising antibodies, reported to inhibit TLR4-mediated inflammation, could prevent the inflammatory response to cobalt ions in an in vitro macrophage cell culture model. Cobalt 147-153 toll like receptor 4 Homo sapiens 26-30 26840091-6 2016 We hypothesised that anti-TLR4 neutralising antibodies, reported to inhibit TLR4-mediated inflammation, could prevent the inflammatory response to cobalt ions in an in vitro macrophage cell culture model. Cobalt 147-153 toll like receptor 4 Homo sapiens 76-80 26840091-7 2016 This study shows that a monoclonal anti-TLR4 antibody inhibited cobalt-mediated increases in pro-inflammatory IL8, CCL20 and IL1A expression, as well as IL-8 secretion. Cobalt 64-70 toll like receptor 4 Homo sapiens 40-44 26840091-10 2016 In summary our data shows that a monoclonal anti-TLR4 antibody can inhibit cobalt-mediated inflammatory responses while a polyclonal antibody only inhibits the effect of specific cytokines. Cobalt 75-81 toll like receptor 4 Homo sapiens 49-53 25803856-5 2015 Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. Cobalt 38-44 toll like receptor 4 Homo sapiens 6-10 25803856-6 2015 Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. Cobalt 22-28 toll like receptor 4 Homo sapiens 14-18 25803856-6 2015 Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. Cobalt 22-28 toll like receptor 4 Homo sapiens 70-74 25803856-7 2015 We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. Cobalt 54-60 toll like receptor 4 Homo sapiens 35-39 28955928-11 2016 These effects were abrogated by the TLR4 antagonist (P<0.001) suggesting that they occur through cobalt activation of TLR4. Cobalt 100-106 toll like receptor 4 Homo sapiens 36-40 28955928-11 2016 These effects were abrogated by the TLR4 antagonist (P<0.001) suggesting that they occur through cobalt activation of TLR4. Cobalt 100-106 toll like receptor 4 Homo sapiens 121-125 28955928-12 2016 This study demonstrates the role of TLR4 in cobalt-mediated immune cell chemotaxis and provides a potential mechanism by which cobalt ions may contribute to the immune cell infiltrate surrounding failed metal hip replacements. Cobalt 44-50 toll like receptor 4 Homo sapiens 36-40 28955928-12 2016 This study demonstrates the role of TLR4 in cobalt-mediated immune cell chemotaxis and provides a potential mechanism by which cobalt ions may contribute to the immune cell infiltrate surrounding failed metal hip replacements. Cobalt 127-133 toll like receptor 4 Homo sapiens 36-40 28955928-13 2016 It also highlights the TLR4 signalling pathway as a potential therapeutic target in preventing cobalt-mediated inflammation. Cobalt 95-101 toll like receptor 4 Homo sapiens 23-27 25183586-2 2014 Cobalt ions activate human toll-like receptor 4 (TLR4), which normally responds to bacterial lipopolysaccharide (LPS) in sepsis. Cobalt 0-6 toll like receptor 4 Homo sapiens 27-47 25458486-1 2015 Nickel, cobalt and palladium ions can induce an innate immune response by triggering Toll-like receptor (TLR)-4 which is present on dendritic cells (DC). Cobalt 8-14 toll like receptor 4 Homo sapiens 105-111 25183586-2 2014 Cobalt ions activate human toll-like receptor 4 (TLR4), which normally responds to bacterial lipopolysaccharide (LPS) in sepsis. Cobalt 0-6 toll like receptor 4 Homo sapiens 49-53 25183586-7 2014 Experiments were also performed in the presence of CLI-095, a TLR4-specific antagonist which abrogated the cobalt-mediated increase in IL-8 and CXCL10 expression. Cobalt 107-113 toll like receptor 4 Homo sapiens 62-66 25183586-8 2014 These findings suggest that cobalt ions induce inflammation similar to that observed during sepsis by the simultaneous activation of two TLR4-mediated signalling pathways. Cobalt 28-34 toll like receptor 4 Homo sapiens 137-141 23692033-0 2013 Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators. Cobalt 66-72 toll like receptor 4 Homo sapiens 28-48 23692033-7 2013 The critical role of TLR4 in nickel-induced, cobalt-induced and palladium-induced activation was confirmed by essentially similar stimulatory patterns obtained in an HEK293 TLR4/MD2 transfectant cell line. Cobalt 45-51 toll like receptor 4 Homo sapiens 21-25 23680697-0 2013 Toll-like receptor 4 signaling pathway mediates proinflammatory immune response to cobalt-alloy particles. Cobalt 83-89 toll like receptor 4 Homo sapiens 0-20 23208186-1 2013 New data demonstrate that cobalt ions promote immune system activation through Toll-like receptor 4 signalling. Cobalt 26-32 toll like receptor 4 Homo sapiens 79-99 23059983-0 2012 Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2. Cobalt 27-33 toll like receptor 4 Homo sapiens 45-49