PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 826600-4 1976 Pretreatment of rats with cobalt (30 min) produced the following changes in PCB actions on heme metabolism in liver: (a) augmentation of the porphyrinogenic effect of PCB, as determined by the total porphyrin content and ALAS activity; (b) augmentation of PCB inhibition of ALAD activity; and (c) blockade of induction of microsomal hemoprotein (cytochrome P-448). Cobalt 26-32 aminolevulinate dehydratase Rattus norvegicus 274-278 1228174-9 1975 Porphobilinogen synthase [EC 4.2.1.24] activity in the liver decreased and reached its minimum value (42% of the control) 12 hr after cobalt injection. Cobalt 134-140 aminolevulinate dehydratase Rattus norvegicus 0-24 1228174-16 1975 Inhibitions of 5-aminolevulinate synthase and porphobilinogen synthase activities by cobalt in vitro were not as marked as expected from in vivo experiments. Cobalt 85-91 aminolevulinate dehydratase Rattus norvegicus 46-70