PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9746341-0 1998 The influence of nickel and cobalt on putative members of the oxygen-sensing pathway of erythropoietin-producing HepG2 cells. Cobalt 28-34 erythropoietin Homo sapiens 88-102 22732165-3 2012 Cobalt (Co(2+)) stabilizes the transcriptional activator hypoxia-inducible factor (HIF) and thus mimics hypoxia and stimulates erythropoietin (Epo) production, but probably also by the same mechanism induces a coordinated up-regulation of a number of adaptive responses to hypoxia, many with potential carcinogenic effects. Cobalt 0-6 erythropoietin Homo sapiens 127-141 22732165-3 2012 Cobalt (Co(2+)) stabilizes the transcriptional activator hypoxia-inducible factor (HIF) and thus mimics hypoxia and stimulates erythropoietin (Epo) production, but probably also by the same mechanism induces a coordinated up-regulation of a number of adaptive responses to hypoxia, many with potential carcinogenic effects. Cobalt 0-6 erythropoietin Homo sapiens 143-146 12620922-9 2003 Additionally, in HepG2 cells QA had a dose-dependent inhibitory effect on hypoxia- and cobalt-induced EPO gene expression without any cell toxicity. Cobalt 87-93 erythropoietin Homo sapiens 102-105 11225250-4 2000 The effects of TNF alpha and IFN-gamma on cobalt-induced erythropoietin production in human hepatic cancer cells(HepG2) were examined. Cobalt 42-48 erythropoietin Homo sapiens 57-71 11225250-8 2000 TNF alpha and IFN-gamma could specifically inhibit cobalt-induced Epo production in HepG2 cells, and suppressed normal bone marrow BFU-E and CFU-E growth in a dose-dependent manner. Cobalt 51-57 erythropoietin Homo sapiens 66-69 25629922-1 2015 Cobalt (Co) can stimulate erythropoietin production in individuals at doses exceeding 25 mg CoCl2/day. Cobalt 0-6 erythropoietin Homo sapiens 26-40 25629922-1 2015 Cobalt (Co) can stimulate erythropoietin production in individuals at doses exceeding 25 mg CoCl2/day. Cobalt 8-11 erythropoietin Homo sapiens 26-40 24039233-3 2014 Cobalt ions (Co(2+) ) stabilize the hypoxia-inducible transcription factors (HIFs) that increase the expression of the erythropoietin (Epo) gene. Cobalt 0-6 erythropoietin Homo sapiens 119-133 24039233-3 2014 Cobalt ions (Co(2+) ) stabilize the hypoxia-inducible transcription factors (HIFs) that increase the expression of the erythropoietin (Epo) gene. Cobalt 0-6 erythropoietin Homo sapiens 135-138 23916558-11 2013 Neuroprotective concentrations of cobalt induced the transcription of the cytokine erythropoietin (EPO) in astrocyte cultures. Cobalt 34-40 erythropoietin Homo sapiens 83-97 23916558-11 2013 Neuroprotective concentrations of cobalt induced the transcription of the cytokine erythropoietin (EPO) in astrocyte cultures. Cobalt 34-40 erythropoietin Homo sapiens 99-102 16863591-3 2006 PRESENTATION OF THE HYPOTHESIS: Cobalt, a naturally-occurring element with properties similar to those of iron and nickel, induces a marked and stable polycythemic response through a more efficient transcription of the erythropoietin gene. Cobalt 32-38 erythropoietin Homo sapiens 219-233 11090055-2 2000 Therefore, the effects of cadmium chloride (Cd) and CDDP in the Hep3B human hepatoma cell line, which up-regulates EPO expression in response to hypoxia and cobalt (Co), were investigated. Cobalt 157-163 erythropoietin Homo sapiens 115-118 11090055-2 2000 Therefore, the effects of cadmium chloride (Cd) and CDDP in the Hep3B human hepatoma cell line, which up-regulates EPO expression in response to hypoxia and cobalt (Co), were investigated. Cobalt 165-168 erythropoietin Homo sapiens 115-118 10699462-8 2000 130 microM DSF, a dose which inhibited heme biosynthesis without cell toxicity, suppressed hypoxia-induced Epo mRNA expression, but enhanced cobalt-induced Epo mRNA expression. Cobalt 141-147 erythropoietin Homo sapiens 156-159 10679259-1 2000 The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction. Cobalt 32-38 erythropoietin Homo sapiens 169-183 10679259-1 2000 The replacement of heme iron by cobalt or nickel in a putative oxygen sensor is supposed to reduce oxygen binding to the heme protein, resulting in HIF-1 activation and erythropoietin (EPO) induction. Cobalt 32-38 erythropoietin Homo sapiens 185-188 9746341-1 1998 Cobalt and nickel stimulate, as does hypoxia, the production of erythropoietin (EPO) in HepG2 cells. Cobalt 0-6 erythropoietin Homo sapiens 64-78 9746341-1 1998 Cobalt and nickel stimulate, as does hypoxia, the production of erythropoietin (EPO) in HepG2 cells. Cobalt 0-6 erythropoietin Homo sapiens 80-83 9027727-1 1997 Cobalt and desferrioxamine, like hypoxia, stimulate the production of erythropoietin in HepG2 cells. Cobalt 0-6 erythropoietin Homo sapiens 70-84 9027736-3 1997 Epo production is induced not only by hypoxia but also by certain transition metal (cobalt and nickel) and by iron chelation. Cobalt 84-90 erythropoietin Homo sapiens 0-3 9027736-5 1997 Epo induction by cobalt was inversely related to iron concentration in the medium, indicating competition between the two metals. Cobalt 17-23 erythropoietin Homo sapiens 0-3 9027736-6 1997 Under hyperbaric oxygen, cobalt induction of erythropoietin mRNA was modestly suppressed while nickel induction was markedly enhanced. Cobalt 25-31 erythropoietin Homo sapiens 45-59 9001239-7 1997 We show that the putative protein binding sites in the EPO enhancer are occupied in vivo under conditions of normoxia, hypoxia, and cobalt exposure in EPO-producing cells. Cobalt 132-138 erythropoietin Homo sapiens 55-58 9001239-7 1997 We show that the putative protein binding sites in the EPO enhancer are occupied in vivo under conditions of normoxia, hypoxia, and cobalt exposure in EPO-producing cells. Cobalt 132-138 erythropoietin Homo sapiens 151-154 9001239-9 1997 We also provide evidence for a conformational change in the topography of the EPO enhancer in response to hypoxia and cobalt exposure. Cobalt 118-124 erythropoietin Homo sapiens 78-81 9027727-12 1997 Incubation with cobalt or with desferrioxamine, however, leads to a decrease of the intracellular H2O2 level as revealed by the dihydrorhodamine 123 technique, perhaps causing the well-known enhanced erythropoietin production. Cobalt 16-22 erythropoietin Homo sapiens 200-214 7836384-2 1995 HIF-1 DNA binding activity is also induced by hypoxia or cobalt in non-Epo-producing cells, suggesting a general role for HIF-1 in hypoxia signal transduction and transcriptional regulation. Cobalt 57-63 erythropoietin Homo sapiens 71-74 8660366-7 1996 Under hyperbaric oxygen, cobalt induction of erythropoietin mRNA was modestly suppressed while nickel induction was markedly enhanced. Cobalt 25-31 erythropoietin Homo sapiens 45-59 8660366-1 1996 Both in vivo and in Hep3B cells, expression of the erythropoietin gene is induced by hypoxia as well as by certain transition metals (cobalt and nickel) and by iron chelation. Cobalt 134-140 erythropoietin Homo sapiens 51-65 8660366-4 1996 Epo induction by cobalt was also affected by iron concentration. Cobalt 17-23 erythropoietin Homo sapiens 0-3 8338939-1 1993 Erythropoietin (Epo) production in response to hypoxia or cobalt is primarily mediated by activation of transcription of the Epo gene. Cobalt 58-64 erythropoietin Homo sapiens 0-14 8034045-0 1994 Effects of cobalt on haem proteins of erythropoietin-producing HepG2 cells in multicellular spheroid culture. Cobalt 11-17 erythropoietin Homo sapiens 38-52 8034045-3 1994 It is concluded that cobalt stimulates a signal cascade with cytochrome b as receptor and H2O2 as second messenger for regulating erythropoietin production. Cobalt 21-27 erythropoietin Homo sapiens 130-144 18671074-1 1994 Cobalt increases the red cell mass in both man and animals by increasing the production of erythropoietin. Cobalt 0-6 erythropoietin Homo sapiens 91-105 8338939-1 1993 Erythropoietin (Epo) production in response to hypoxia or cobalt is primarily mediated by activation of transcription of the Epo gene. Cobalt 58-64 erythropoietin Homo sapiens 16-19 8338939-1 1993 Erythropoietin (Epo) production in response to hypoxia or cobalt is primarily mediated by activation of transcription of the Epo gene. Cobalt 58-64 erythropoietin Homo sapiens 125-128 8486613-0 1993 Erythropoietin 5"-flanking sequence-binding protein induced during hypoxia and cobalt exposure. Cobalt 79-85 erythropoietin Homo sapiens 0-14 1311742-4 1992 Cobalt also produced a significant increase in medium and cell erythropoietin levels. Cobalt 0-6 erythropoietin Homo sapiens 63-77 1448072-1 1992 Transcription of the human erythropoietin (Epo) gene is stimulated by exposure to hypoxia and/or cobalt in whole animals and in Hep3B cells. Cobalt 97-103 erythropoietin Homo sapiens 27-41 1448072-1 1992 Transcription of the human erythropoietin (Epo) gene is stimulated by exposure to hypoxia and/or cobalt in whole animals and in Hep3B cells. Cobalt 97-103 erythropoietin Homo sapiens 43-46 2304468-5 1990 Human EPO RNA in tgEPO10 mice was detected only in liver of anemic or cobalt-treated mice. Cobalt 70-76 erythropoietin Homo sapiens 6-9 1985694-15 1991 These results demonstrate the presence of promoter and enhancer elements within the human Epo gene that are appropriately responsive to hypoxia and cobalt. Cobalt 148-154 erythropoietin Homo sapiens 90-93 2849206-4 1988 New protein synthesis is required before the induction of increased levels of hypoxia- or cobalt-induced Epo mRNA. Cobalt 90-96 erythropoietin Homo sapiens 105-108 2849206-7 1988 This hypothesis is further supported by the finding that when heme synthesis is blocked, hypoxia-, cobalt-, and nickel-induced Epo production are all markedly inhibited. Cobalt 99-105 erythropoietin Homo sapiens 127-130 2849206-8 1988 A model is proposed in which a ligand-dependent conformational change in a heme protein accounts for the mechanism by which hypoxia as well as cobalt and nickel stimulate the production of Epo. Cobalt 143-149 erythropoietin Homo sapiens 189-192 13499580-1 1958 V. The effect of cobalt on the production of erythropoietin. Cobalt 17-23 erythropoietin Homo sapiens 45-59 4370141-0 1974 Lactate stimulation of renal cortical adenylate cyclase: a mechanism for erythropoietin production following cobalt treatment or hypoxia. Cobalt 109-115 erythropoietin Homo sapiens 73-87 4793125-0 1973 A comparison of the cobalt, methylene blue, zinc, arsenite and amino triazole effect on erythropoietin production. Cobalt 20-26 erythropoietin Homo sapiens 88-102 4751887-0 1973 [Level of erythropoietin in the serum of employees of the hydrometallurgical production of cobalt]. Cobalt 91-97 erythropoietin Homo sapiens 10-24 5895765-2 1965 Studies on the mechanism of erythropoietin production by cobalt]. Cobalt 57-63 erythropoietin Homo sapiens 28-42 4339071-0 1972 Increased kidney cyclic AMP levels and erythropoietin production following cobalt administration. Cobalt 75-81 erythropoietin Homo sapiens 39-53 33142033-2 2020 Amongst other strategies, the administration of ionic cobalt (Co2+ ) can increase the number of erythrocytes by stimulating the endogenous erythropoietin (EPO) biosynthesis. Cobalt 54-60 erythropoietin Homo sapiens 139-153 33142033-2 2020 Amongst other strategies, the administration of ionic cobalt (Co2+ ) can increase the number of erythrocytes by stimulating the endogenous erythropoietin (EPO) biosynthesis. Cobalt 54-60 erythropoietin Homo sapiens 155-158 30283349-1 2018 Introduction: Cobalt ions (Co2+) stabilize HIFalpha and increase endogenous erythropoietin (EPO) production creating the possibility that Co2+ supplements (CoSupp) may be used as performance enhancing substances. Cobalt 14-20 erythropoietin Homo sapiens 76-90 30283349-1 2018 Introduction: Cobalt ions (Co2+) stabilize HIFalpha and increase endogenous erythropoietin (EPO) production creating the possibility that Co2+ supplements (CoSupp) may be used as performance enhancing substances. Cobalt 14-20 erythropoietin Homo sapiens 92-95