PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Cobalt	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	170-183	
31198997-6	2019	Unlike keratinocytes, normal human fibroblasts expressed high levels of TLR4 mRNA and induced interleukin-8 expression upon stimulation with nickel or cobalt.	Cobalt	151-157	C-X-C motif chemokine ligand 8	Homo sapiens	94-107	
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Cobalt	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	191-196	
28955928-4	2016	Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2.	Cobalt	38-44	C-X-C motif chemokine ligand 8	Homo sapiens	185-189	
26840091-7	2016	This study shows that a monoclonal anti-TLR4 antibody inhibited cobalt-mediated increases in pro-inflammatory IL8, CCL20 and IL1A expression, as well as IL-8 secretion.	Cobalt	64-70	C-X-C motif chemokine ligand 8	Homo sapiens	110-113	
25183586-4	2014	This study was designed to determine whether cobalt induces a similar inflammatory response to LPS by promoting the expression of IL-8 and CXCL10.	Cobalt	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	130-134	
25183586-6	2014	Cobalt-treated macrophages showed a 60-fold increase in IL-8 mRNA, and an eightfold increase in production of the mature chemokine (both p < 0.001); expression of the CXCL10 gene and protein was also significantly increased by cobalt (both p < 0.001).	Cobalt	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	56-60	
25183586-7	2014	Experiments were also performed in the presence of CLI-095, a TLR4-specific antagonist which abrogated the cobalt-mediated increase in IL-8 and CXCL10 expression.	Cobalt	107-113	C-X-C motif chemokine ligand 8	Homo sapiens	135-139	
19132727-6	2009	We demonstrate that cobalt ions rapidly induce the protein secretion of IL-8 and MCP-1 in primary human osteoblasts.	Cobalt	20-26	C-X-C motif chemokine ligand 8	Homo sapiens	72-76	
23629852-7	2013	Cobalt increased secretion of IL8 and MCP1 significantly, and upregulated the expression of ICAM-1 in ECs compared to stimulation by chromium and controls.	Cobalt	0-6	C-X-C motif chemokine ligand 8	Homo sapiens	30-33	
19132727-10	2009	In aggregate these data demonstrate that cobalt ions can activate transcription of the chemokine genes IL-8 and MCP-1 in primary human osteoblasts.	Cobalt	41-47	C-X-C motif chemokine ligand 8	Homo sapiens	103-107	
34086734-0	2021	Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt.	Cobalt	108-114	C-X-C motif chemokine ligand 8	Homo sapiens	56-61	
34086734-12	2021	A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations.	Cobalt	45-51	C-X-C motif chemokine ligand 8	Homo sapiens	87-92