PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23864114-10	2013	Taken together, this work suggested that cobalt resistance is not merely dependent upon activation of AFT1, but it likely implicates other mechanisms including intracellular reallocation of iron into important compartments whose function is dependent on this metal and adaptation of some cellular proteins to use Co(2+) in place of Fe(2+) for their catalytic activities.	Cobalt	41-47	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	102-106	
12176980-4	2002	Like iron starvation, cobalt stress induces accumulation of the Aft1 protein in the nucleus to activate transcription of its target genes.	Cobalt	22-28	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	64-68	
12176980-5	2002	Cells lacking the AFT1 gene (aft1) are hypersensitive to cobalt as well as to other transition metals, whereas expression of the dominant AFT1-1(up) allele, which results in up-regulation of AFT1-controlled genes, confers resistance.	Cobalt	57-63	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	18-22	
12176980-5	2002	Cells lacking the AFT1 gene (aft1) are hypersensitive to cobalt as well as to other transition metals, whereas expression of the dominant AFT1-1(up) allele, which results in up-regulation of AFT1-controlled genes, confers resistance.	Cobalt	57-63	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	29-33	
12176980-6	2002	Cobalt resistance correlates with an increase in intracellular iron in AFT1-1(up) cells, and sensitivity of aft1 cells is associated with a lack of iron accumulation.	Cobalt	0-6	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	71-75	
12176980-7	2002	Furthermore, elevated iron levels in the growth medium suppress the cobalt sensitivity of the aft1 mutant cells, even though they increase cellular cobalt.	Cobalt	68-74	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	94-98	
12176980-8	2002	Results presented indicate that yeast cells acquire cobalt tolerance by activating the Aft1p-dependent iron regulon and thereby increasing intracellular iron levels.	Cobalt	52-58	DNA-binding transcription factor AFT1	Saccharomyces cerevisiae S288C	87-92