PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22808498-8	2012	Orthodontic structures made from chromium-cobalt, or chromium-nickel alloys in the oral cavity of these patients increased the levels of MMP-2, IL-1beta and IL-6 in oral fluid.	Cobalt	42-48	interleukin 6	Homo sapiens	157-161	
18547706-7	2008	The metal allergens nickel and cobalt could be detected by measuring Interleukin-6 and macrophage inflammatory protein 1-beta (MIP-1beta, CCL-4) in coculture supernatants.	Cobalt	31-37	interleukin 6	Homo sapiens	69-82	
19844976-6	2010	Furthermore, cobalt, molybdenum ions, and Co-Cr-Mo alloy particles similarly induce elevated secretion of IL-1beta, TNFalpha, and IL-6.	Cobalt	13-19	interleukin 6	Homo sapiens	130-134	
8314823-7	1993	In contrast, exposure to cobalt-chromium particles was associated with a decreased release of prostaglandin E2 and interleukin-6, and it had little effect on the release of interleukin-1 and tumor necrosis factor.	Cobalt	25-31	interleukin 6	Homo sapiens	115-128	
9840004-8	1998	Increased IL-6 levels were observed in cultures exposed to copper (5-19-fold compared to untreated controls), zinc (16-fold), cobalt (12-fold), nickel (10-fold) and palladium (4-fold).	Cobalt	126-132	interleukin 6	Homo sapiens	10-14	
12143988-4	2002	We also found that cobalt ion-enriched medium increased the production of interleukin-6 from the osteoblast-like cells.	Cobalt	19-25	interleukin 6	Homo sapiens	74-87	
9186223-5	1997	Cobalt at concentrations ranging from 0.1 to 100 ng/ml significantly enhanced the release of interleukin-6, but titanium and chromium did not.	Cobalt	0-6	interleukin 6	Homo sapiens	93-106	
8953156-7	1996	The release of IL-2 and IL-6 by PHA-stimulated PBMC was significantly inhibited by titanium, chromium, and cobalt.	Cobalt	107-113	interleukin 6	Homo sapiens	24-28	
34955648-10	2021	Results: Co and Ni both significantly increased IL-6 secretion in human BSMCs at 300 muM.	Cobalt	9-11	interleukin 6	Homo sapiens	48-52	
34955648-12	2021	BSMCs transfected with OGR1-siRNA produced less IL-6 than BSMCs transfected with NT-siRNA in response to either Co or Ni stimulation.	Cobalt	112-114	interleukin 6	Homo sapiens	48-52	
34955648-15	2021	Conclusion: Co and Ni induce secretion of IL-6 in human BSMCs through activation of OGR1.	Cobalt	12-14	interleukin 6	Homo sapiens	42-46	
28736908-5	2017	Cobalt-treated monocytes/macrophages presented significantly elevated levels of interleukin 6 (IL-6) and tumor necrosis factor (TNF), both of which were suppressed by the addition of exogenous BMP-7.	Cobalt	0-6	interleukin 6	Homo sapiens	80-93	
34086734-0	2021	Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt.	Cobalt	108-114	interleukin 6	Homo sapiens	50-54	
34086734-12	2021	A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations.	Cobalt	45-51	interleukin 6	Homo sapiens	81-85	
34086734-12	2021	A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations.	Cobalt	45-51	interleukin 6	Homo sapiens	147-151	
29610530-2	2018	We now demonstrate that exposure of cobalt and chromium NPs to BeWo cell barriers, an in vitro model of the human placenta, triggers impairment of the autophagic flux and release of interleukin-6.	Cobalt	36-42	interleukin 6	Homo sapiens	182-195	
28736908-5	2017	Cobalt-treated monocytes/macrophages presented significantly elevated levels of interleukin 6 (IL-6) and tumor necrosis factor (TNF), both of which were suppressed by the addition of exogenous BMP-7.	Cobalt	0-6	interleukin 6	Homo sapiens	95-99	
28736908-7	2017	Cobalt-treated monocytes/macrophages effectively supported Th17 inflammation, by an IL-6-dependent but not TNF-dependent mechanism.	Cobalt	0-6	interleukin 6	Homo sapiens	84-88	
28684418-7	2017	The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells.	Cobalt	17-23	interleukin 6	Homo sapiens	79-83	
28955928-6	2016	This study investigated the effect of cobalt on the secretion of inflammatory cytokines CCL20 and IL-6.	Cobalt	38-44	interleukin 6	Homo sapiens	98-102	
28955928-9	2016	Cobalt ions significantly increased release of CCL2 and IL-6 by MonoMac 6 cells (P<0.001).	Cobalt	0-6	interleukin 6	Homo sapiens	56-60	
26557039-12	2015	The ions of cobalt released from the surface of the implant are absorbed by present macrophages, which are involved in many of the processes associated with phagocytose orthopaedic biomaterials particles and release pro-inflammatory mediators such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-alpha), and prostaglandin.	Cobalt	12-18	interleukin 6	Homo sapiens	273-286	
26557039-12	2015	The ions of cobalt released from the surface of the implant are absorbed by present macrophages, which are involved in many of the processes associated with phagocytose orthopaedic biomaterials particles and release pro-inflammatory mediators such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-alpha), and prostaglandin.	Cobalt	12-18	interleukin 6	Homo sapiens	288-292