PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24486411-0	2014	Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae.	Cobalt	27-33	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	0-4	
24486411-2	2014	In the present study, we have investigated how the transcription factor Yap1 mediates tolerance to cobalt toxicity.	Cobalt	99-105	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	72-76	
24486411-3	2014	METHODS: Fluorescence microscopy was used to address how cobalt activates Yap1.	Cobalt	57-63	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	74-78	
24486411-6	2014	RESULTS: Cobalt activates Yap1 under aerobiosis and anaerobiosis growth conditions.	Cobalt	9-15	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	26-30	
24486411-8	2014	However, when challenged with high concentrations of cobalt, yap1 mutant cells accumulate lower levels of this metal.	Cobalt	53-59	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	61-65	
24486411-10	2014	Moreover, we show that Yap1 is a repressor of the low affinity iron transporter, FET4, which is also known to transport cobalt.	Cobalt	120-126	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	23-27	
24486411-11	2014	CONCLUSIONS: Cobalt activates Yap1 that alleviates the oxidative damage caused by this metal.	Cobalt	13-19	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	30-34	
24486411-12	2014	Yap1 partially controls cobalt cellular uptake via the regulation of PHO84.	Cobalt	24-30	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	0-4	
24486411-14	2014	GENERAL SIGNIFICANCE: Our results emphasize the important role of Yap1 in mediating cobalt-induced oxidative damages and reveal new routes for cell protection provided by this regulator.	Cobalt	84-90	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	66-70