PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22312014-3 2012 OBJECTIVES: To test the hypothesis that Nrf2-dependent up-regulation of the HO-1/carbon monoxide (CO) system would preserve mitochondrial biogenesis and rescue mice from lethal S. aureus sepsis. Cobalt 98-100 heme oxygenase 1 Mus musculus 76-80 22312014-5 2012 MEASUREMENTS AND MAIN RESULTS: Sepsis survival was significantly enhanced using inhaled CO (250 ppm once-daily for 1 h), and linked mechanistically to Hmox1 induction and mitochondrial HO activity through Nrf2 transcriptional and Akt kinase activity. Cobalt 88-90 heme oxygenase 1 Mus musculus 151-156