PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15322724-8	2005	Methohexital and midazolam both tended to decrease ACTH and cortisol at large doses, and increase these hormones at small doses, but the HPA effects of neither drug differed significantly from when saline was available.	Midazolam	17-26	proopiomelanocortin	Homo sapiens	51-55	
2830806-3	1987	Etomidate and midazolam both prevent the normal perioperative cortisol increase in minor surgery, but the mechanisms by which they do this are not identical: etomidate inhibits steroid synthesis in the adrenal cortex, leading to low cortisol and high ACTH levels, whereas midazolam primarily prevents ACTH increases.	Midazolam	14-23	proopiomelanocortin	Homo sapiens	251-255	
8067555-5	1994	By 14 days after the first ESI (7 days after the second ESI), plasma ACTH was more suppressed in the group receiving midazolam and plasma cortisol was markedly suppressed in both groups.	Midazolam	117-126	proopiomelanocortin	Homo sapiens	69-73	
8067555-6	1994	At 48 days after the first ESI (34 days after the third ESI), plasma ACTH and cortisol were significantly suppressed only in the group that had received midazolam before each ESI.	Midazolam	153-162	proopiomelanocortin	Homo sapiens	69-73	
8985717-3	1996	ACTH response was significantly lower after flumazenil administration than after saline or midazolam.	Midazolam	91-100	proopiomelanocortin	Homo sapiens	0-4	
2830806-3	1987	Etomidate and midazolam both prevent the normal perioperative cortisol increase in minor surgery, but the mechanisms by which they do this are not identical: etomidate inhibits steroid synthesis in the adrenal cortex, leading to low cortisol and high ACTH levels, whereas midazolam primarily prevents ACTH increases.	Midazolam	14-23	proopiomelanocortin	Homo sapiens	301-305	
3034107-6	1987	The cortisol decrease from 12.5 +/- 1.7 to 7.6 +/- 1.5 caused by midazolam was similar to that following etomidate, but the response to exogenous ACTH was significantly impaired in patients receiving etomidate as compared to those receiving midazolam.	Midazolam	241-250	proopiomelanocortin	Homo sapiens	146-150	
3034107-8	1987	Midazolam on the other hand prevented the increase of ACTH and beta-endorphin levels.	Midazolam	0-9	proopiomelanocortin	Homo sapiens	54-58	
3034107-8	1987	Midazolam on the other hand prevented the increase of ACTH and beta-endorphin levels.	Midazolam	0-9	proopiomelanocortin	Homo sapiens	63-77	
31827553-14	2019	The combination of midazolam and TEAS was superior to midazolam alone for cough suppression during FB, probably due to increased plasma beta-endorphin levels.	Midazolam	19-28	proopiomelanocortin	Homo sapiens	136-150