PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12061540-4	2002	To investigate the effects of KTZ on CYP metabolic activities, 7-ethoxyresorufin, tolbutamide, bufuralol, and midazolam hydrochloride were used as specific substrates for CYP1A1/2, CYP2C21, CYP2D15, and CYP3A12, respectively.	Midazolam	110-133	Cytochrome P450 1A1	Canis lupus familiaris	171-177	
33674269-3	2021	In vitro metabolism of midazolam (MDZ) and DCA in recombinant canine CYP1A1, 1A2, 2B11, 2C21, 2C41, 2D15, 3A12, 3A26 enzymes clarified that CYP3A12 was primarily responsible for either the oxidation elimination of MDZ or the regioselective oxidation metabolism of DCA into DCA-1beta-ol and DCA-5beta-ol in dog liver microsomes.	Midazolam	23-32	Cytochrome P450 1A1	Canis lupus familiaris	69-75	
33674269-3	2021	In vitro metabolism of midazolam (MDZ) and DCA in recombinant canine CYP1A1, 1A2, 2B11, 2C21, 2C41, 2D15, 3A12, 3A26 enzymes clarified that CYP3A12 was primarily responsible for either the oxidation elimination of MDZ or the regioselective oxidation metabolism of DCA into DCA-1beta-ol and DCA-5beta-ol in dog liver microsomes.	Midazolam	34-37	Cytochrome P450 1A1	Canis lupus familiaris	69-75