PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27323294-1 2016 Cytochrome P450 (P450) 3A (CYP3A) is an enzyme responsible for the metabolism of therapeutic drugs such as midazolam, nifedipine, testosterone and triazolam. Midazolam 107-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-25 31164617-3 2019 The metabolic rates of caffeine, dextromethorphan, midazolam, omeprazole, and Losartan to the CYP-specific metabolites are validated measures of in vivo CYP 1A2, 2D6, 3A4, 2C19, and 2C9 activities, respectively. Midazolam 51-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 94-97 28686070-0 2018 Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Midazolam 148-157 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-93 25940755-3 2015 CYP activity was assessed by the apparent clearance of midazolam (CYP3A), omeprazole/5-hydroxyomeprazol ratio in plasma (CYP2C19) and losartan/E3174 ratio in urine (CYP2C9). Midazolam 55-64 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 22513143-7 2012 In human hepatic microsomes metabolite formation was correlated with CYP3A4-mediated midazolam 1"-hydroxylation, but not with other CYP-specific substrate oxidations. Midazolam 85-94 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-72 23071008-1 2013 Induction of the cytochrome P450 (CYP) family of enzymes by coadministered compounds can result in drug-drug interactions, as in the case of the coadministration of rifampicin with many CYP3A substrates, including midazolam. Midazolam 214-223 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-32 23071008-1 2013 Induction of the cytochrome P450 (CYP) family of enzymes by coadministered compounds can result in drug-drug interactions, as in the case of the coadministration of rifampicin with many CYP3A substrates, including midazolam. Midazolam 214-223 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-37 22483397-2 2012 CYP isoform specific substrates and their metabolites of CYP1A2 (caffeine), CYP2C9 (losartan), CYP2C19 (omeprazole), CYP2D6 (dextromethorphan) and CYP3A (midazolam) were all simultaneously analyzed using LC-MS/MS after administration of a mixture of five drugs (i.e., a "cocktail approach") to healthy volunteers. Midazolam 154-163 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 20002088-4 2009 * This cocktail can be used to test the effects of a new chemical entity on multiple CYP isoforms in a single clinical study: CYP1A2 (caffeine), CYP2C9 (warfarin), CYP2C19 (omeprazole), CYP2D6 (metoprolol), and CYP3A (midazolam) and was designed to overcome potential liabilities of other reported cocktails. Midazolam 218-227 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 85-88 21198441-2 2011 The specific CYP substrates used in this cocktail assay included phenacetin (CYP1A2), bupropion (CYP2B6), amodiaquine (CYP2C8), tolbutamide (CYP2C9), S-mephenytoin (CYP2C19), dextromethorphan (CYP2D6), and midazolam (CYP3A4/5). Midazolam 206-215 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-16 16857327-7 2006 Correlation analysis between the known CYP enzyme activities and the rates of the formation of 5-hydroxy- and 7-hydroxy-KR-33028 in the 16 human liver microsomes has showed significant correlations with CYP3A4-mediated midazolam 1"-hydroxylation and CYP1A2-mediated phenacetin O-deethylation, respectively. Midazolam 219-228 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-42 19356015-2 2007 The CYP form with the lowest in vitro K(i) is evaluated first clinically, employing a suitable probe drug like midazolam (CYP3A4), theophylline (CYP1A2), (S)-warfarin (CYP2C9) and desipramine (CYP2D6), and the NCE is classified as a "none", "weak", "moderate", or "strong" inhibitor. Midazolam 111-120 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-7 18634893-3 2008 METHODS: The assay consisted of human liver microsomes and a cocktail of probe substrates metabolized by the five major CYP isoforms (tacrine for CYP1A2, diclofenac for CYP2C9, (S)-mephenytoin for CYP2C19, dextromethorphan for CYP2D6 and midazolam for CYP3A4). Midazolam 238-247 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 120-123 17452028-2 2007 Consequently dextromethorphan, flurbiprofen, midazolam and other compounds are commonly used as probe substrates to evaluate cytochrome P450 function in humans. Midazolam 45-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 125-140 12751920-14 2003 While triazolam and midazolam are biotransformed almost entirely via CYP3A4, the newer hypnosedatives are biotransformed by several CYP isozymes in addition to CYP3A4, resulting in CYP3A4 inhibitors and inducers having a lesser effect on their biotransformation. Midazolam 20-29 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-72 16243813-0 2005 Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients. Midazolam 112-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-90 16243813-1 2005 PURPOSE: To evaluate the effect of naturally occurring variants in genes encoding the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in patients with cancer receiving midazolam as a phenotyping probe. Midazolam 169-178 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 86-101 16243813-1 2005 PURPOSE: To evaluate the effect of naturally occurring variants in genes encoding the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in patients with cancer receiving midazolam as a phenotyping probe. Midazolam 169-178 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-106 11013424-3 2000 A highly efficient direct injection on-line guard cartridge extraction/tandem mass spectrometry (DI-GCE/MS/MS) method has been validated for high-throughput evaluation of cytochrome P450 (CYP) 3A4, 2D6 and 2E1 inhibition potential via cassette dosing of midazolam, dextromethorphan and chlorzoxazone using human hepatic microsomes and 96-well microtiter plates. Midazolam 254-263 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 171-186 11013424-3 2000 A highly efficient direct injection on-line guard cartridge extraction/tandem mass spectrometry (DI-GCE/MS/MS) method has been validated for high-throughput evaluation of cytochrome P450 (CYP) 3A4, 2D6 and 2E1 inhibition potential via cassette dosing of midazolam, dextromethorphan and chlorzoxazone using human hepatic microsomes and 96-well microtiter plates. Midazolam 254-263 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 188-191 34877801-1 2022 This study was designed to evaluate the effects of cenobamate, an antiseizure medication for focal seizures, on the pharmacokinetics (PK) of cytochrome P450 probes (bupropion, CYP2B6; midazolam, CYP3A4/5; warfarin, CYP2C9; omeprazole, CYP2C19) in healthy subjects. Midazolam 184-193 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 141-156 10460798-1 1999 Activities of testosterone, nifedipine, and midazolam oxidation by recombinant cytochrome P-450 (P-450) 3A4 coexpressed with human NADPH-P-450 reductase (NPR) in bacterial membranes (CYP3A4/NPR membranes) were determined in comparison with those of other recombinant systems and of human liver microsomes with high contents of CYP3A4. Midazolam 44-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-95 8886602-1 1996 Midazolam (MDZ) is metabolized in human liver microsomes by the cytochrome P450 (CYP) 3A subfamily to 1"-hydroxy (1"-OH) and 4-hydroxy (4-OH) metabolites. Midazolam 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-79 8886602-1 1996 Midazolam (MDZ) is metabolized in human liver microsomes by the cytochrome P450 (CYP) 3A subfamily to 1"-hydroxy (1"-OH) and 4-hydroxy (4-OH) metabolites. Midazolam 11-14 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-79 33935788-14 2021 The correlation analysis between CYP protein abundance and CYP enzyme activity showed that CYP3A22 protein abundance correlated clearly with the metabolism of midazolam at PND 7. Midazolam 159-168 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 33-36 3196361-9 1988 For a better understanding of the cytochrome P-450 mediated reactions, we studied the metabolism of midazolam in microsomal fractions prepared from twelve human livers. Midazolam 100-109 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 34-50 3196361-11 1988 Furthermore, and since we demonstrated that midazolam was predominantly transformed by a single cytochrome P-450 enzyme, we could attribute the large inter-individual variations in midazolam metabolism to differences in human liver cytochrome P-450 content. Midazolam 44-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 96-112 3196361-11 1988 Furthermore, and since we demonstrated that midazolam was predominantly transformed by a single cytochrome P-450 enzyme, we could attribute the large inter-individual variations in midazolam metabolism to differences in human liver cytochrome P-450 content. Midazolam 44-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 232-248 3196361-11 1988 Furthermore, and since we demonstrated that midazolam was predominantly transformed by a single cytochrome P-450 enzyme, we could attribute the large inter-individual variations in midazolam metabolism to differences in human liver cytochrome P-450 content. Midazolam 181-190 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 96-112 3196361-11 1988 Furthermore, and since we demonstrated that midazolam was predominantly transformed by a single cytochrome P-450 enzyme, we could attribute the large inter-individual variations in midazolam metabolism to differences in human liver cytochrome P-450 content. Midazolam 181-190 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 232-248 33935788-14 2021 The correlation analysis between CYP protein abundance and CYP enzyme activity showed that CYP3A22 protein abundance correlated clearly with the metabolism of midazolam at PND 7. Midazolam 159-168 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-62 31494843-14 2020 The in vitro CYP inhibition study only found very weak action for CYP3A4 (midazolam 1"-hydroxylation) and CYP3A4 (midazolam 6beta-hydroxylation) with IC50 of 56.8 microM and 41.1 microM, respectively. Midazolam 74-83 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-16 31494843-14 2020 The in vitro CYP inhibition study only found very weak action for CYP3A4 (midazolam 1"-hydroxylation) and CYP3A4 (midazolam 6beta-hydroxylation) with IC50 of 56.8 microM and 41.1 microM, respectively. Midazolam 114-123 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-16