PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29489460-10 2018 MEASUREMENTS AND MAIN RESULTS: Midazolam significantly reduced the expression of PER2 in the suprachiasmatic nucleus and the hippocampus of wild-type mice. Midazolam 31-40 period circadian clock 2 Mus musculus 81-85 29489460-14 2018 Subsequent studies in Per2 mice confirmed a functional role of PER2 in a midazolam-induced delirium-like phenotype. Midazolam 73-82 period circadian clock 2 Mus musculus 22-26 29489460-14 2018 Subsequent studies in Per2 mice confirmed a functional role of PER2 in a midazolam-induced delirium-like phenotype. Midazolam 73-82 period circadian clock 2 Mus musculus 63-67 29489460-15 2018 Using the small molecule nobiletin to enhance PER2 function, the cognitive deficits induced by midazolam or constant light were attenuated in wild-type mice. Midazolam 95-104 period circadian clock 2 Mus musculus 46-50 29489460-16 2018 CONCLUSIONS: These experiments identify a novel role for PER2 during a midazolam- or constant light-induced delirium-like state, highlight the importance of hippocampal PER2 expression for cognitive function, and suggest the PER2 enhancer nobiletin as potential therapy in delirium-like conditions associated with circadian disruption. Midazolam 71-80 period circadian clock 2 Mus musculus 57-61 32294028-1 2020 BACKGROUND: We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Midazolam 92-101 period circadian clock 2 Mus musculus 73-81 32294028-1 2020 BACKGROUND: We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Midazolam 92-101 period circadian clock 2 Mus musculus 83-87 32294028-6 2020 RESULTS: Midazolam treatment significantly downregulated Adora2b or Per2 mRNA in the hippocampus of C57BL/6J mice, and hippocampal PER2 protein expression or T-maze alternation was significantly reduced in Adora2b-/- mice. Midazolam 9-18 period circadian clock 2 Mus musculus 68-72 32294028-11 2020 Further, our data demonstrate that BAY-60-6583 treatment restores midazolam induced cognitive dysfunction, possibly via increases of Per2. Midazolam 66-75 period circadian clock 2 Mus musculus 133-137 30246635-0 2018 The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury. Midazolam 74-83 period circadian clock 2 Mus musculus 14-18 30246635-4 2018 Unexpectedly, only midazolam treatment resulted in an immediate and significant downregulation of Per2 transcript levels. Midazolam 19-28 period circadian clock 2 Mus musculus 98-102 30246635-6 2018 Using the recently identified flavonoid, nobiletin, as a PER2 enhancer completely abolished the deleterious effects of midazolam during myocardial IR-injury. Midazolam 119-128 period circadian clock 2 Mus musculus 57-61 30246635-9 2018 CONCLUSION: We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury. Midazolam 26-35 period circadian clock 2 Mus musculus 71-75 30246635-9 2018 CONCLUSION: We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury. Midazolam 131-140 period circadian clock 2 Mus musculus 71-75 30246635-10 2018 These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancers nobiletin or tangeritin as a preventative therapy for myocardial IR-injury in the perioperative setting where midazolam pretreatment occurs frequently. Midazolam 203-212 period circadian clock 2 Mus musculus 78-82