PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29489460-10	2018	MEASUREMENTS AND MAIN RESULTS: Midazolam significantly reduced the expression of PER2 in the suprachiasmatic nucleus and the hippocampus of wild-type mice.	Midazolam	31-40	period circadian clock 2	Mus musculus	81-85	
29489460-14	2018	Subsequent studies in Per2 mice confirmed a functional role of PER2 in a midazolam-induced delirium-like phenotype.	Midazolam	73-82	period circadian clock 2	Mus musculus	22-26	
29489460-14	2018	Subsequent studies in Per2 mice confirmed a functional role of PER2 in a midazolam-induced delirium-like phenotype.	Midazolam	73-82	period circadian clock 2	Mus musculus	63-67	
29489460-15	2018	Using the small molecule nobiletin to enhance PER2 function, the cognitive deficits induced by midazolam or constant light were attenuated in wild-type mice.	Midazolam	95-104	period circadian clock 2	Mus musculus	46-50	
29489460-16	2018	CONCLUSIONS: These experiments identify a novel role for PER2 during a midazolam- or constant light-induced delirium-like state, highlight the importance of hippocampal PER2 expression for cognitive function, and suggest the PER2 enhancer nobiletin as potential therapy in delirium-like conditions associated with circadian disruption.	Midazolam	71-80	period circadian clock 2	Mus musculus	57-61	
32294028-1	2020	BACKGROUND: We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction.	Midazolam	92-101	period circadian clock 2	Mus musculus	73-81	
32294028-1	2020	BACKGROUND: We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction.	Midazolam	92-101	period circadian clock 2	Mus musculus	83-87	
32294028-6	2020	RESULTS: Midazolam treatment significantly downregulated Adora2b or Per2 mRNA in the hippocampus of C57BL/6J mice, and hippocampal PER2 protein expression or T-maze alternation was significantly reduced in Adora2b-/- mice.	Midazolam	9-18	period circadian clock 2	Mus musculus	68-72	
32294028-11	2020	Further, our data demonstrate that BAY-60-6583 treatment restores midazolam induced cognitive dysfunction, possibly via increases of Per2.	Midazolam	66-75	period circadian clock 2	Mus musculus	133-137	
30246635-0	2018	The Circadian PER2 Enhancer Nobiletin Reverses the Deleterious Effects of Midazolam in Myocardial Ischemia and Reperfusion Injury.	Midazolam	74-83	period circadian clock 2	Mus musculus	14-18	
30246635-4	2018	Unexpectedly, only midazolam treatment resulted in an immediate and significant downregulation of Per2 transcript levels.	Midazolam	19-28	period circadian clock 2	Mus musculus	98-102	
30246635-6	2018	Using the recently identified flavonoid, nobiletin, as a PER2 enhancer completely abolished the deleterious effects of midazolam during myocardial IR-injury.	Midazolam	119-128	period circadian clock 2	Mus musculus	57-61	
30246635-9	2018	CONCLUSION: We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury.	Midazolam	26-35	period circadian clock 2	Mus musculus	71-75	
30246635-9	2018	CONCLUSION: We identified midazolam mediated downregulation of cardiac PER2 as an underlying mechanism for a deleterious effect of midazolam pretreatment in myocardial IR-injury.	Midazolam	131-140	period circadian clock 2	Mus musculus	71-75	
30246635-10	2018	These findings highlight PER2 as a cardioprotective mechanism and suggest the PER2 enhancers nobiletin or tangeritin as a preventative therapy for myocardial IR-injury in the perioperative setting where midazolam pretreatment occurs frequently.	Midazolam	203-212	period circadian clock 2	Mus musculus	78-82