PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20080160-0	2010	Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.	Midazolam	30-39	nuclear receptor subfamily 1 group I member 2	Homo sapiens	58-77	
20080160-8	2010	Consistently, two-hybrid mammalian assay using hybrid fusion plasmids GAL4-PXR ligand-binding domain (LBD) and VP16-SRC-1-receptor-interacting domain (RID) confirmed PXR activation by Midazolam and Medazepam.	Midazolam	184-193	nuclear receptor subfamily 1 group I member 2	Homo sapiens	166-169	
20080160-10	2010	Medazepam and Midazolam slightly activated pregnane X receptor and displayed weak potency to induce CYP3A4 mRNA in human hepatocytes.	Midazolam	14-23	nuclear receptor subfamily 1 group I member 2	Homo sapiens	43-62	
17050801-3	2006	In contrast, 3 linked hPXR variants (g.252A > G, g.275A > G, and g.4760G > A) were significantly (P < .05) associated with oral midazolam clearance in a mixed race/ethnicity population (n = 26) and the African American subpopulation (n = 14) but not in European Americans (n = 9).	Midazolam	140-149	nuclear receptor subfamily 1 group I member 2	Homo sapiens	22-26	
17050801-4	2006	Although the amount of hPXR mRNA normally spliced at the exon 4-5 junction correlated well with midazolam 1"-hydroxylation activities (P < .05), none of the 6 hPXR mRNA splice variants identified was associated with midazolam 1"-hydroxylation.	Midazolam	96-105	nuclear receptor subfamily 1 group I member 2	Homo sapiens	23-27	
17050801-5	2006	In conclusion, several hPXR polymorphisms have been identified that may have predictive value for oral midazolam clearance, particularly in African Americans.	Midazolam	103-112	nuclear receptor subfamily 1 group I member 2	Homo sapiens	23-27