PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25482326-7 2015 The pretreatment of rats with midazolam before the second exposure to the aversive context significantly attenuated the conditioned fear response, lowered the serum corticosterone concentration, decreased c-Fos and CRF expressions in the MeA and in the BLA, and increased CRF complex density in M1 area only in the LR group. Midazolam 30-39 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 205-210 26318100-7 2015 Acute midazolam administration significantly attenuated the neophobia and conditioned fear responses, decreased c-Fos expression in the LA and CeA, and increased alpha-2 subunit density in the CeA only in the HR group. Midazolam 6-15 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 112-117 12145054-0 2002 Midazolam induces expression of c-Fos and EGR-1 by a non-GABAergic mechanism. Midazolam 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-37 15115808-7 2004 Midazolam inhibited Fos expression in key limbic regions involved in pheromone transduction (medial amygdala and bed nucleus of the stria terminalis) and defensive behavior (prelimbic cortex, lateral septum, lateral and medial preoptic areas, and dorsal premammillary nucleus). Midazolam 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 20-23 12147189-7 2002 Midazolam-pretreatment inhibited the increase of Fos protein expression, not cyclic AMP content, in rat spinal cord during morphine withdrawal. Midazolam 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 49-52 19699782-9 2009 Fos immunohistochemistry showed that midazolam injections were associated with a distinct pattern of action when administered before the test or retest session, and the anterior cingulate cortex, area 1 (Cg1), was the only structure targeted by the benzodiazepine in both situations. Midazolam 37-46 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-3 19211972-0 2008 Inhibition of neophobia-stimulated c-Fos expression in the dorsomedial part of the prefrontal cortex in rats pretreated with midazolam. Midazolam 125-134 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 35-40 19211972-1 2008 The effect of an anxiolytic drug, midazolam, on the expression of c-Fos protein (the product of the immediate early gene, c-fos) in the rat brain was studied in animals that were exposed to the stress of neophobia using the open field test. Midazolam 34-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 66-71 19211972-1 2008 The effect of an anxiolytic drug, midazolam, on the expression of c-Fos protein (the product of the immediate early gene, c-fos) in the rat brain was studied in animals that were exposed to the stress of neophobia using the open field test. Midazolam 34-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 122-127 19211972-2 2008 Midazolam (0.5 mg/kg, ip) selectively and significantly attenuated the neophobia-induced increase in the number of Fos-like immunoreactive neurons in the dorsomedial part of the prefrontal cortex, but not in the primary motor cortex, the piriform cortex or the amygdalar nuclei. Midazolam 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 115-118 16372144-0 2006 Midazolam inhibits neophobia-induced Fos expression in the rat hippocampus. Midazolam 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 37-40 16372144-1 2006 The effect of midazolam on expression of c-Fos protein was examined in the rat hippocampus, following the open field test of neophobia. Midazolam 14-23 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 41-46 16372144-2 2006 It was found that pretreatment of rats with midazolam, at the dose of 0.5 mg/kg, enhanced rat exploratory behavior, and inhibited neophobia related stimulation of c-Fos in the CA-1 and CA-3 areas of the hippocampus. Midazolam 44-53 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 163-168 15740792-8 2005 Immunocytochemistry, histochemistry and western blot were performed to determine the effect of midazolam on formalin-induced expression of Fos protein, nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) and nitric oxide synthase (NOS) in chronic morphine-tolerant rats, respectively. Midazolam 95-104 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-142 15740792-10 2005 In chronic morphine-tolerant rats, pretreatment with midazolam significantly decreased the formalin-induced expression of Fos and Fos/NADPH-d double-labeled neurons in the contralateral spinal cord and NADPH-d positive neurons in the bilateral spinal cord. Midazolam 53-62 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 122-125 15740792-10 2005 In chronic morphine-tolerant rats, pretreatment with midazolam significantly decreased the formalin-induced expression of Fos and Fos/NADPH-d double-labeled neurons in the contralateral spinal cord and NADPH-d positive neurons in the bilateral spinal cord. Midazolam 53-62 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 130-133 12717145-9 2003 Midazolam inhibited N(2)O-induced c-Fos expression (a marker of neuronal activation) in the pontine A7 and spinal cord. Midazolam 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 34-39 12145054-5 2002 The midazolam-induced c-Fos and EGR-1 expression was abolished by PD98059, an inhibitor for mitogen- activated protein kinase/extracellular signal-regulated kinase kinase, suggesting the involvement of extracellular signal-regulated kinases (ERKs). Midazolam 4-13 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 22-27 12145054-7 2002 These results indicate that midazolam induces the expression of c-Fos and EGR-1, by activation of ERKs through a mechanism independent from gamma-aminobutyric acid(A) receptors, in PC12 cells, and suggest the possibility that midazolam can induce long-term changes of neural functions by changing gene expression. Midazolam 28-37 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 64-69 12145054-7 2002 These results indicate that midazolam induces the expression of c-Fos and EGR-1, by activation of ERKs through a mechanism independent from gamma-aminobutyric acid(A) receptors, in PC12 cells, and suggest the possibility that midazolam can induce long-term changes of neural functions by changing gene expression. Midazolam 226-235 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 64-69 12145054-4 2002 In contrast, midazolam dose- and time-dependently induced expression of c-Fos and EGR-1, which was not affected by antagonists of the benzodiazepine receptors, flumazenil and PK11195. Midazolam 13-22 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-77 10587093-0 1999 Baclofen and midazolam alter c-fos induction by peripheral noxious or innocuous stimulation in the spinal cord of normal and monoarthritic rats. Midazolam 13-22 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 29-34 10587093-12 1999 The paradoxical facilitation of c-fos expression by midazolam in monoarthritic animals, may be due to the reported increase in spinal GABA levels found in those animals. Midazolam 52-61 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 32-37 7970238-6 1994 The results indicate that fentanyl/midazolam is the most recommendable anesthetic drug in the Fos expression study. Midazolam 35-44 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 94-97