PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3605877-6	1987	Some of the new cephalosporins of the third generation (cefotaxime and ceftriaxone) and cefuroxime have a good activity in vitro and a good passage to the CSF.	Cefotaxime	56-66	colony stimulating factor 2	Homo sapiens	155-158	
2689353-14	1989	CSF penetration of cefotaxime was evaluated in seven patients: concentrations ranged from 0.499 mg/l to 2.829 mg/l.	Cefotaxime	19-29	colony stimulating factor 2	Homo sapiens	0-3	
2963304-6	1987	Mean CSF concentrations of cefotaxime, desacetylcefotaxime and fosfomycin on the 2nd and 15th days of treatment were 4, 3.5 and 39.8 mg/l and 2.2, 2.1 and 28.0 mg/l, respectively.	Cefotaxime	27-37	colony stimulating factor 2	Homo sapiens	5-8	
6276458-4	1982	Nine concentrations of cefotaxime in lumbar and ventricular CSF out of 19 in a group of seven neurosurgical patients with mild to moderate impairment of the blood-CSF-barrier were higher than 0.5 micrograms/ml.	Cefotaxime	23-33	colony stimulating factor 2	Homo sapiens	60-63	
6094430-2	1984	The CSF concentrations of cefotaxime fluctuated around 4 mg/l.	Cefotaxime	26-36	colony stimulating factor 2	Homo sapiens	4-7	
6094452-3	1984	Three hours after the end of the infusion, mean CSF concentrations of cefotaxime and fosfomycin were respectively at day 2 3.2 mg/l and 31.4 mg/l, at day 4 2.9 mg/l and 33.9 mg/l.	Cefotaxime	70-80	colony stimulating factor 2	Homo sapiens	48-51	
6330021-3	1984	Mean concentration of cefotaxime in CSF ranged from 0.8 mg/l (aseptic meningitis), to 6.4 mg/l (Gram-negative and listeria meningitis), and from 0.5 to 5.4 mg/l for the metabolite.	Cefotaxime	22-32	colony stimulating factor 2	Homo sapiens	36-39	
6311128-5	1983	Trough CSF levels of cefotaxime (range, 5.6 to 44.3 micrograms/mL) and desacetylcefotaxime (3.7 to 44.0 micrograms/mL) were manyfold greater than the minimal bactericidal concentrations of the causative pathogens with the exception of the one Pseudomonas aeruginosa isolate.	Cefotaxime	21-31	colony stimulating factor 2	Homo sapiens	7-10	
6288338-2	1982	All isolated micro-organisms were highly sensitive to it in serial dilution, except for one case, and were quickly removed from blood and CSF by the administration of cefotaxim alone.	Cefotaxime	167-176	colony stimulating factor 2	Homo sapiens	138-141	
6288338-4	1982	Thus cefotaxim has a high antibacterial activity and satisfactory CSF passage in purulent meningitis caused by sensitive, especially gram-negative, bacteria and is well suitable for therapy, if penicillins alone or combined are not applicable or effective.	Cefotaxime	5-14	colony stimulating factor 2	Homo sapiens	66-69	
6269429-4	1981	The newer cephalosporins or cehalosporin-type antibiotics (cefotaxime, moxalactam), by virtue of their marked activity against gram-negative bacilli and their ability to achieve significant CSF levels, merit serious consideration as therapy for gram-negative bacillary meningitis.	Cefotaxime	59-69	colony stimulating factor 2	Homo sapiens	190-193	
7654271-2	1994	The authors recommend an initial antimicrobial regimen associating cefotaxime or ceftriaxone to vancomycin in any case of bacterial meningitis in which S pneumoniae appears to be involved (Gram positive cocci on direct examination of the CSF and/or presence of soluble bacterial antigen).	Cefotaxime	67-77	colony stimulating factor 2	Homo sapiens	238-241	
9303415-1	1997	Cerebrospinal fluid (CSF) was taken from 19 children with bacterial meningitis treated with cefotaxime (300 mg/kg of body weight/day) and vancomycin (60 mg/kg/day).	Cefotaxime	92-102	colony stimulating factor 2	Homo sapiens	0-25	
9303415-2	1997	Median levels of drugs in CSF were smaller than expected, as follows: 4.4 microg/ml for cefotaxime, 3.2 microg/ml for desacetylcefotaxime, and 1.7 microg/ml for vancomycin.	Cefotaxime	88-98	colony stimulating factor 2	Homo sapiens	26-29	
9303415-3	1997	The median CSF bactericidal titer against an intermediately cefotaxime-resistant pneumococcus was 1:4.	Cefotaxime	60-70	colony stimulating factor 2	Homo sapiens	11-14	
6259596-0	1981	[Cefotaxime CSF levels in children with purulent meningitis (author"s transl)].	Cefotaxime	1-11	colony stimulating factor 2	Homo sapiens	12-15	
6259609-5	1981	Because cefotaxime is active at low concentration and has a good diffusion in the CSF, it provides a particularly effective treatment in Gram-negative meningitis in children.	Cefotaxime	8-18	colony stimulating factor 2	Homo sapiens	82-85	
6101414-5	1980	CSF levels were measured in seven children and ranged from 300 to 27 200 microgram/l; published and unpublished in-vitro studies suggest that minimum inhibitory concentrations for cefotaxime against the organisms commonly causing bacterial meningitis are usually well below 250 microgram/l.	Cefotaxime	180-190	colony stimulating factor 2	Homo sapiens	0-3	
2091255-2	1990	Review of recent data from the USA and Europe indicates that delayed CSF sterilization occurs significantly more often with ampicillin/chloramphenicol and cefuroxime than with ceftriaxone and cefotaxime.	Cefotaxime	192-202	colony stimulating factor 2	Homo sapiens	69-72