PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29967397-3	2018	We previously identified 48 mutations in TEM-1 beta-lactamase that increased resistance of Escherichia coli to cefotaxime, 10 of which were synonymous.	Cefotaxime	111-121	TEM-1 beta-lactamase	Escherichia coli	41-61	
3884565-3	1985	When an E. coli strain producing high levels of TEM-1 beta-lactamase constituted 6% or more of the population, the whole colony was resistant to cefamandole, but still sensitive to cefotaxime, cefoxitin or imipenem.	Cefotaxime	181-191	TEM-1 beta-lactamase	Escherichia coli	48-68	
11224569-4	2001	To test this theory, TEM-1 beta-lactamase was evolved using a hypermutator E. coli-based directed evolution technique with cefotaxime selection.	Cefotaxime	123-133	TEM-1 beta-lactamase	Escherichia coli	21-41	
10699880-4	2000	We applied this approach to TEM-1 beta-lactamase which confers resistance to 0.05 mg/L of the antibiotic cefotaxime.	Cefotaxime	105-115	TEM-1 beta-lactamase	Escherichia coli	28-48