PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34145657-4	2021	We subject populations of the beta-lactamase TEM-1 to directed evolution in Escherichia coli under both low- and high-mistranslation rates, selecting for high activity on the substrate cefotaxime.	Cefotaxime	185-195	hypothetical protein	Escherichia coli	45-50	
9189637-7	1997	We demonstrated this in Escherichia coli strains harbouring TEM-1, TEM-12 and TEM-10 beta-lactamases challenged by cefotaxime, and also Streptococcus pneumoniae strains with various levels of penicillin resistance challenged by amoxicillin or cefotaxime.	Cefotaxime	115-125	hypothetical protein	Escherichia coli	60-65	
34145657-5	2021	Under low mistranslation rates, different evolving TEM-1 populations ascend the same high cefotaxime-resistance peak, which requires three canonical DNA mutations.	Cefotaxime	90-100	hypothetical protein	Escherichia coli	51-56	
35052944-6	2022	Results show that cefotaxime is the preferred inducer for CTX-M-15 and amoxicillin for TEM-1, whereas oxacillin for OXA-2.	Cefotaxime	18-28	hypothetical protein	Escherichia coli	87-92	
2692515-4	1989	The beta-lactamase efficiently hydrolyzed cefotaxime and ceftriaxone but only moderately hydrolyzed ceftazidime and was inhibited by clavulanate and sulbactam (1 microM) and by anti-TEM-1 and anti-TEM-2 sera.	Cefotaxime	42-52	hypothetical protein	Escherichia coli	182-187	
2661324-4	1989	However, the TEM-E1 enzyme differs from TEM-1 by its low rates and efficiency of hydrolysis for ceftazidime and cefotaxime, TEM-E1 has similar efficiency of hydrolysis values for ceftazidime and cefotaxime, but only confers resistance to ceftazidime.	Cefotaxime	112-122	hypothetical protein	Escherichia coli	40-45	
28524864-3	2017	Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Escherichia coli strain with a high mistranslation rate.	Cefotaxime	92-102	hypothetical protein	Escherichia coli	49-54	
28524864-4	2017	TEM-1 populations evolved in such strains endow host cells with a general growth advantage, not only on cefotaxime but also on several other antibiotics that ancestral TEM-1 had been unable to deactivate.	Cefotaxime	104-114	hypothetical protein	Escherichia coli	0-5	
35134504-0	2022	Efficacy of piperacillin-tazobactam and cefotaxime against Escherichia coli hyperproducing TEM-1 in a mouse peritonitis infection model.	Cefotaxime	40-50	hypothetical protein	Escherichia coli	91-96