PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12176910-7	2002	In addition to increasing receptor expression, GM-CSF treatment enhanced the interleukin 8 (IL-8) secretion and superoxide priming responses of neutrophils to stimulation with TLR2 ligands, including zymosan, peptidoglycan, and lipoarabinomannan.	Zymosan	200-207	colony stimulating factor 2	Homo sapiens	47-53	
8077677-1	1994	After priming with cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, or IL-5, eosinophils are stimulated potently by opsonized particles like serum-treated zymosan (STZ), resulting in activation of the respiratory burst and production of lipid mediators, such as platelet-activating factor (PAF) and leukotriene C4 (LTC4).	Zymosan	190-197	colony stimulating factor 2	Homo sapiens	38-86	
8077677-1	1994	After priming with cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3, or IL-5, eosinophils are stimulated potently by opsonized particles like serum-treated zymosan (STZ), resulting in activation of the respiratory burst and production of lipid mediators, such as platelet-activating factor (PAF) and leukotriene C4 (LTC4).	Zymosan	190-197	colony stimulating factor 2	Homo sapiens	88-94	
8077677-8	1994	In contrast, iC3b-zymosan induced significantly less PAF release by GM-CSF-primed eosinophils than did IgG/iC3b-zymosan, suggesting synergism between Fc gamma RII and CR3.	Zymosan	18-25	colony stimulating factor 2	Homo sapiens	68-74	
2545809-1	1989	Granulocyte-macrophage colony-stimulating factor, GM-CSF, potentiates superoxide generation produced by human neutrophils stimulated with fMet-Leu-Phe and platelet-activating factor, PAF, but not by phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan.	Zymosan	250-257	colony stimulating factor 2	Homo sapiens	0-48	
2168838-6	1990	Human GM-CSF also primed dog granulocytes for increased production of reactive oxygen metabolites in response to either phorbolmyristic acetate-or zymosan-activated dog serum.	Zymosan	147-154	colony stimulating factor 2	Homo sapiens	6-12	
8300150-9	1993	It is hypothesized that the reason for the different sensitivity of FMLP-receptors and receptors to zymosan particles to rH GM-CSF priming may lie in differences in the signal-transduction pathways of these receptor types.	Zymosan	100-107	colony stimulating factor 2	Homo sapiens	124-130	
2545809-1	1989	Granulocyte-macrophage colony-stimulating factor, GM-CSF, potentiates superoxide generation produced by human neutrophils stimulated with fMet-Leu-Phe and platelet-activating factor, PAF, but not by phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan.	Zymosan	250-257	colony stimulating factor 2	Homo sapiens	50-56	
3021817-2	1986	The purified rH GM-CSF enhanced the cytotoxic activity of neutrophils and eosinophils against antibody-coated targets, stimulated phagocytosis of serum-opsonized yeast by both cell types in a dose-dependent manner, and stimulated neutrophil-mediated iodination in the presence of zymosan.	Zymosan	280-287	colony stimulating factor 2	Homo sapiens	16-22	
6301584-8	1983	CSF-alpha stimulated superoxide production of resting eosinophils (from 0.03 +/- 0.03 to 0.47 +/- 0.08 nmole cytochrome-c reduced/10(5) eosinophils) and of eosinophils incubated with preopsonized zymosan (from 0.15 +/- 0.06 to 0.73 +/- 0.07).	Zymosan	196-203	colony stimulating factor 2	Homo sapiens	0-3	
21486701-0	2011	GM-CSF plays a key role in zymosan-stimulated human dendritic cells for activation of Th1 and Th17 cells.	Zymosan	27-34	colony stimulating factor 2	Homo sapiens	0-6	
21486701-2	2011	The specific effects of zymosan on the expression of several key cytokines, including granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukins (IL-1alpha, IL-1beta and IL-12 p70) were quite distinct from the effects of LPS.	Zymosan	24-31	colony stimulating factor 2	Homo sapiens	86-134	
21486701-5	2011	Furthermore, the GM-CSF secreted by zymosan-activated DCs enhanced IL-23 production, resulting in activation of a Th17 response.	Zymosan	36-43	colony stimulating factor 2	Homo sapiens	17-23	
21486701-8	2011	We suggest that this novel zymosan-induced GM-CSF-mediated signaling network may play a key role in regulating specific immune cell type activities.	Zymosan	27-34	colony stimulating factor 2	Homo sapiens	43-49	
15661041-6	2005	Imatinib also reduced the ability of M-CSF and GM-CSF stimulated CM to phagocytose zymosan particles, with uptake of non-opsonized zymosan by M-CSF stimulated CM (M-CM) being most affected.	Zymosan	83-90	colony stimulating factor 2	Homo sapiens	47-53