PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25092526-8	2014	RESULTS: Mannan, beta-glucans (curdlan), chitosan, and zymosan induced the secretion of interleukin (IL)-1beta, IL-6, IL-23, IL-10, and tumor necrosis factor-alpha by PBMCs.	Zymosan	55-62	interleukin 6	Homo sapiens	112-116	
26949603-7	2016	RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner.	Zymosan	34-41	interleukin 6	Homo sapiens	61-65	
20224557-8	2010	In addition, monocytes from hypertensive women homozygous for the 249Ser allele showed a lower release of tumor necrosis factor-alpha and interleukin-6 in response to zymosan (TLR6 agonist), but not to lipopolysaccharide (TLR4 agonist).	Zymosan	167-174	interleukin 6	Homo sapiens	138-151	
22116002-6	2012	Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1.	Zymosan	122-129	interleukin 6	Homo sapiens	158-162	
22116002-7	2012	LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents.	Zymosan	20-27	interleukin 6	Homo sapiens	151-155	
20107167-7	2010	RESULTS: Zymosan induced the release of IL-6 and IL-8 from corneal fibroblasts without affecting either the release of IL-1beta, IL-12, IP-10, or RANTES or the expression of ICAM-1 or VCAM-1.	Zymosan	9-16	interleukin 6	Homo sapiens	40-44	
20107167-9	2010	The zymosan-induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38, JNK, and NF-kappaB signaling.	Zymosan	4-11	interleukin 6	Homo sapiens	31-35	
20107167-10	2010	CONCLUSIONS: Zymosan induces the release of IL-6 and IL-8 from human corneal fibroblasts in a manner dependent on MAPK and NF-kappaB signaling pathways.	Zymosan	13-20	interleukin 6	Homo sapiens	44-48	
17049124-5	2006	RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice.	Zymosan	188-197	interleukin 6	Homo sapiens	122-126	
16501050-8	2006	Zymosan induced the expression of tumor necrosis factor alpha (TNF-alpha), TNF-beta, IL-10, IL-6, and MCP-2/CCL8, whereas the cytokine signature of C3bi-coated zymosan also included interferon-inducible protein 10/CXC chemokine ligand 10, platelet-derived growth factor-BB, and I-309/CCL1.	Zymosan	0-7	interleukin 6	Homo sapiens	92-96	
14973543-7	2004	An intra-articular injection of zymosan, 3 days after Ad5.IL-1/IL-6-Luc, increased Luc.	Zymosan	32-39	interleukin 6	Homo sapiens	63-67	
15196211-4	2004	In response to zymosan and flagellin, pathogen-associated molecular patterns (PAMP) that are recognized by TLR2 and TLR5 respectively, ECC-1 cells secreted significantly more IL-8, MCP-1 and IL-6 than in response to other TLR agonists.	Zymosan	15-22	interleukin 6	Homo sapiens	191-195	
12727366-6	2003	Prolonged incubation of both serum-opsonized and -unopsonized zymosan particles with HUVEC induced increased secretion of the proinflammatory cytokines IL-6 and IL-8 to the cell culture supernatants, but had no effect on production of oxygen radicals.	Zymosan	62-69	interleukin 6	Homo sapiens	152-156	
12225373-5	2002	Stimulation with zymosan and LPS readily induced interleukin (IL)-6 and IL-8 cytokine production in the placenta cultures, whereas TLR2 and TLR4 mRNA and protein expression remained at the same high level as in unstimulated explants.	Zymosan	17-24	interleukin 6	Homo sapiens	49-67	
9510942-5	1998	The used stimulators-zymosan and lipopolysaccharide (LPS) resulted in increased IL-6sR secretion by PMNs and WBC of patients but did not influence IL-6 production by the same cells.	Zymosan	21-28	interleukin 6	Homo sapiens	80-84	
9495792-5	1997	However, in the activated microglia (amoeboid microglia) stimulated with Zymosan A, radiation-induced IL-6 mRNA expression was increased about two-fold in comparison with non-irradiation.	Zymosan	73-82	interleukin 6	Homo sapiens	102-106	
8326131-5	1993	This antiserum was found to block, in a dose-dependent manner, 1) zymosan-induced neutrophil chemotaxis, 2) C5a-induced enzyme release from neutrophils, and 3) C5a-induced cytokine production (IL-6 and IL-8) from human monocytes in vitro.	Zymosan	66-73	interleukin 6	Homo sapiens	193-197	
10824456-5	2000	The amounts of drained TNF-alpha and IL-6 in the lymph peaked at 2-4 hr and 4-8 hr after zymosan administration, respectively.	Zymosan	89-96	interleukin 6	Homo sapiens	37-41