PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8435211-3	1993	Here we report on the effect of E2 and tamoxifen (TAM) on IGF-II mRNA and protein expression in the ER+T61 human breast cancer xenograft.	Tamoxifen	50-53	insulin like growth factor 2	Homo sapiens	58-64	
8435211-8	1993	TAM treatment of T61 tumours, which results in inhibition of tumour growth without tumour regression, reduced IGF-II mRNA expression approximately 10-fold after 48 h of treatment.	Tamoxifen	0-3	insulin like growth factor 2	Homo sapiens	110-116	
1381703-2	1992	In this study we have examined the effect of treatment with Tamoxifen, medroxyprogesterone acetate (MPA) or 4-hydroxyandrostenedione (4-OHA) on plasma IGF-I and IGF-II concentrations.	Tamoxifen	60-69	insulin like growth factor 2	Homo sapiens	161-167	
1661135-8	1991	The antiestrogens tamoxifen and 4-hydroxytamoxifen were found to enhance the growth stimulation resulting from Zn2+ induced IGF-II production in MI7 cells.	Tamoxifen	18-27	insulin like growth factor 2	Homo sapiens	124-130	
33081566-1	2020	AIM: In this study, we explored the ability of TAMs to affect the malignant phenotype of human hepatoma Huh-7 cells through the Gli2/IGF-II/ERK1/2 pathway.	Tamoxifen	47-51	insulin like growth factor 2	Homo sapiens	133-139	
33081566-12	2020	CONCLUSION: The TGF-beta1 secreted by TAMs promotes the migration, invasion and EMT of human hepatoma Huh-7 cells through the Gli2/IGF-II/ERK1/2 pathway.	Tamoxifen	38-42	insulin like growth factor 2	Homo sapiens	131-137	
15072444-0	2004	Tamoxifen modulation of etoposide cytotoxicity involves inhibition of protein kinase C activity and insulin-like growth factor II expression in brain tumor cells.	Tamoxifen	0-9	insulin like growth factor 2	Homo sapiens	100-129	
15072444-8	2004	While P-gp, IGF-IR and IGF-I were not affected, enhanced inhibition of PKC, and IGF-II were observed in brain tumor cells treated with tamoxifen and etoposide combination as compared to cells treated with either drug alone.	Tamoxifen	135-144	insulin like growth factor 2	Homo sapiens	80-86	
15072444-11	2004	These results suggest that inhibitory effect of tamoxifen on brain tumor cells manifest through different mechanisms involving inhibition of targets such as PKC and IGF-II.	Tamoxifen	48-57	insulin like growth factor 2	Homo sapiens	165-171	
11759825-4	2001	Compared with placebo, tamoxifen induced a mean +/- standard error (SE) reduction of IGF-I of 16.9 +/- 7.8%, p < 0.05, a non-significant increase of 22.9 +/- 12.2% in IGF-II, an increase in IGFBP-1 of 49.3 +/- 22.7%, p < 0.05, and a non-significant change of IGFBP-3 (-4.0% +/- 9.2).	Tamoxifen	23-32	insulin like growth factor 2	Homo sapiens	170-176	
10070856-10	1999	These experiments indicate that E2 may sensitize tamoxifen-resistant MCF 7/5-23 cells to the growth stimulatory actions of IGF-2 via up-regulation of the IGF-1R and describes a cell-survival mechanism that may manifest itself as tamoxifen resistance.	Tamoxifen	49-58	insulin like growth factor 2	Homo sapiens	123-128	
10070856-10	1999	These experiments indicate that E2 may sensitize tamoxifen-resistant MCF 7/5-23 cells to the growth stimulatory actions of IGF-2 via up-regulation of the IGF-1R and describes a cell-survival mechanism that may manifest itself as tamoxifen resistance.	Tamoxifen	229-238	insulin like growth factor 2	Homo sapiens	123-128