PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34815764-10 2022 Therefore, the present study suggests that the H19 gene regulates NAT1 expression in TAM-resistant cells via the mediation of NAT1 promoter methylation. Tamoxifen 85-88 H19 imprinted maternally expressed transcript Homo sapiens 47-50 33667788-5 2021 Paclitaxel, doxorubicin, tamoxifen, erlotinib, gefitinib, temozolomide, and methotrexate are among therapeutic agents whose efficacy is influenced by the expression of H19. Tamoxifen 25-34 H19 imprinted maternally expressed transcript Homo sapiens 168-171 33179087-0 2021 Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cells. Tamoxifen 81-90 H19 imprinted maternally expressed transcript Homo sapiens 27-30 33179087-1 2021 The H19 long non-coding RNA is involved in the development of tamoxifen resistance in breast cancer. Tamoxifen 62-71 H19 imprinted maternally expressed transcript Homo sapiens 4-7 33179087-2 2021 However, the relationship between H19 and the metastatic potential and treatment options for tamoxifen-resistant (TAMR) breast cancer is not completely understood. Tamoxifen 93-102 H19 imprinted maternally expressed transcript Homo sapiens 34-37 31340867-4 2019 Here, we assessed the role of H19 in the development of tamoxifen-resistant breast cancer. Tamoxifen 56-65 H19 imprinted maternally expressed transcript Homo sapiens 30-33 31340867-5 2019 METHODS: Quantitative real-time PCR analyzed expression of H19 in tamoxifen-resistant breast cancer tissues. Tamoxifen 66-75 H19 imprinted maternally expressed transcript Homo sapiens 59-62 31340867-6 2019 Knockdown of H19 was used to assess the sensitivity to tamoxifen in vitro and in vivo. Tamoxifen 55-64 H19 imprinted maternally expressed transcript Homo sapiens 13-16 31340867-8 2019 Real-time quantitative methylation-specific polymerase chain reaction, chromatin immunoprecipitation, immunofluorescence, and Western blot were used to explore the tamoxifen resistance mechanism of H19. Tamoxifen 164-173 H19 imprinted maternally expressed transcript Homo sapiens 198-201 31340867-9 2019 RESULTS: In this study, we observed that the expression of H19 was substantially upregulated in tamoxifen-resistant breast cancer cell line and tumor tissues, and knockdown of H19 enhanced the sensitivity to tamoxifen both in vitro and in vivo. Tamoxifen 96-105 H19 imprinted maternally expressed transcript Homo sapiens 59-62 31340867-9 2019 RESULTS: In this study, we observed that the expression of H19 was substantially upregulated in tamoxifen-resistant breast cancer cell line and tumor tissues, and knockdown of H19 enhanced the sensitivity to tamoxifen both in vitro and in vivo. Tamoxifen 208-217 H19 imprinted maternally expressed transcript Homo sapiens 59-62 31340867-9 2019 RESULTS: In this study, we observed that the expression of H19 was substantially upregulated in tamoxifen-resistant breast cancer cell line and tumor tissues, and knockdown of H19 enhanced the sensitivity to tamoxifen both in vitro and in vivo. Tamoxifen 208-217 H19 imprinted maternally expressed transcript Homo sapiens 176-179 31340867-10 2019 Furthermore, knockdown of H19 significantly inhibited autophagy in MCF7 tamoxifen-resistant (MCF7/TAMR) cells. Tamoxifen 72-81 H19 imprinted maternally expressed transcript Homo sapiens 26-29 31340867-12 2019 Interestingly, overexpression of H19 in MCF7 tamoxifen-sensitive cells could recapitulate tamoxifen resistance. Tamoxifen 45-54 H19 imprinted maternally expressed transcript Homo sapiens 33-36 31340867-12 2019 Interestingly, overexpression of H19 in MCF7 tamoxifen-sensitive cells could recapitulate tamoxifen resistance. Tamoxifen 90-99 H19 imprinted maternally expressed transcript Homo sapiens 33-36 31340867-16 2019 CONCLUSIONS: Our findings demonstrate that H19 induces autophagy activation via the H19/SAHH/DNMT3B axis, which could contribute to tamoxifen resistance in breast cancer. Tamoxifen 132-141 H19 imprinted maternally expressed transcript Homo sapiens 43-46 31340867-16 2019 CONCLUSIONS: Our findings demonstrate that H19 induces autophagy activation via the H19/SAHH/DNMT3B axis, which could contribute to tamoxifen resistance in breast cancer. Tamoxifen 132-141 H19 imprinted maternally expressed transcript Homo sapiens 84-87 30519041-9 2018 Results: We found that lncRNA H19 expression level manipulated breast cancer cell proliferation both in parental breast cancer cell lines and tamoxifen-resistant cell lines. Tamoxifen 142-151 H19 imprinted maternally expressed transcript Homo sapiens 30-33 30519041-10 2018 Knockdown of lncRNA H19 elevated tamoxifen sensitivity for promoting cell growth and inhibiting apoptosis in tamoxifen-resistant breast cancer cells. Tamoxifen 33-42 H19 imprinted maternally expressed transcript Homo sapiens 20-23 30519041-10 2018 Knockdown of lncRNA H19 elevated tamoxifen sensitivity for promoting cell growth and inhibiting apoptosis in tamoxifen-resistant breast cancer cells. Tamoxifen 109-118 H19 imprinted maternally expressed transcript Homo sapiens 20-23 30519041-11 2018 Moreover, knockdown of H19 inhibited Wnt pathway and epithelia-mesenchymal transition in tamoxifen-resistance breast cancer cells. Tamoxifen 89-98 H19 imprinted maternally expressed transcript Homo sapiens 23-26 30519041-12 2018 Conclusion: Taken together, the results of this study provided the evidence for H19 in regulating tamoxifen-resistant breast cancer and might provide novel options in the future treatment of tamoxifen-resistance breast cancer patients. Tamoxifen 98-107 H19 imprinted maternally expressed transcript Homo sapiens 80-83 30519041-12 2018 Conclusion: Taken together, the results of this study provided the evidence for H19 in regulating tamoxifen-resistant breast cancer and might provide novel options in the future treatment of tamoxifen-resistance breast cancer patients. Tamoxifen 191-200 H19 imprinted maternally expressed transcript Homo sapiens 80-83 34815764-0 2022 Long non-coding RNA H19 mediates N-acetyltransferase 1 gene methylation in the development of tamoxifen resistance in breast cancer. Tamoxifen 94-103 H19 imprinted maternally expressed transcript Homo sapiens 20-23 34815764-2 2022 H19 lncRNA has been demonstrated to be an estrogen-inducible gene, the expression of which is significantly increased in tamoxifen (TAM)-resistant MCF-7 breast cancer cells. Tamoxifen 121-130 H19 imprinted maternally expressed transcript Homo sapiens 0-3 34815764-2 2022 H19 lncRNA has been demonstrated to be an estrogen-inducible gene, the expression of which is significantly increased in tamoxifen (TAM)-resistant MCF-7 breast cancer cells. Tamoxifen 132-135 H19 imprinted maternally expressed transcript Homo sapiens 0-3 34815764-3 2022 The aim of the present study was to investigate the role and molecular mechanism of lncRNA H19 in the development of TAM resistance. Tamoxifen 117-120 H19 imprinted maternally expressed transcript Homo sapiens 91-94 34815764-7 2022 The results further demonstrated that N-acetyltransferase 1 (NAT1) may serve an important role in TAM-resistant cells, as NAT1 expression was notably downregulated in the MCF-7R cells but significantly elevated following the knockdown of H19. Tamoxifen 98-101 H19 imprinted maternally expressed transcript Homo sapiens 238-241 34815764-8 2022 In addition, lower expression of NAT1 and higher expression of H19 were indicated to be associated with poor prognosis in patients with breast cancer treated with TAM. Tamoxifen 163-166 H19 imprinted maternally expressed transcript Homo sapiens 63-66 34815764-9 2022 The results of bisulfite genomic sequencing PCR analysis indicated that the methylation rate of NAT1 in MCF-7R cells was significantly higher compared with that in MCF-7 cells, while the methylation rate of NAT1 in TAM-resistant cells transfected with small interfering RNA against H19 was significantly lower than that in the corresponding untransfected cells. Tamoxifen 215-218 H19 imprinted maternally expressed transcript Homo sapiens 282-285 30497079-8 2018 RESULTS: Here we report that treating ETR cells with Tam or Fulvestrant increases H19 expression and that it"s decreased expression overcomes resistance to Tam and Fulvestrant in these cells. Tamoxifen 53-56 H19 imprinted maternally expressed transcript Homo sapiens 82-85 30497079-9 2018 Interestingly, H19 expression is regulated by Notch and HGF signaling in the ETR cells and pharmacological inhibitors of Notch and c-MET signaling together significantly reverse resistance to Tam and Fulvestrant in an H19-dependent manner in these cells. Tamoxifen 192-195 H19 imprinted maternally expressed transcript Homo sapiens 15-18