PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23700476-12	2013	The significant correlation between ADC7D and ERbeta-positive cell density suggests that ERbeta may play an important role as a therapeutic indicator of tamoxifen.	Tamoxifen	153-162	estrogen receptor 2	Rattus norvegicus	46-52	
34242875-9	2021	SI increased ERalpha and decreased ERbeta in the hippocampus, which were mitigated by tamoxifen.	Tamoxifen	86-95	estrogen receptor 2	Rattus norvegicus	35-41	
30316077-12	2018	Furthermore, treatment with TAM prevented the reduction of estrogen receptors (ERs) alpha and beta protein levels, but its effect on the ERbeta protein level was higher.	Tamoxifen	28-31	estrogen receptor 2	Rattus norvegicus	137-143	
23911387-8	2013	ERalpha and ERbeta agonists induced an increase in T cell proliferation and IFN-gamma production and these effects were inhibited by tamoxifen.	Tamoxifen	133-142	estrogen receptor 2	Rattus norvegicus	12-18	
27554391-5	2016	We show that the effects of tamoxifen rely on modulation of the estrogen receptors ERalpha, ERbeta, and GPR30.	Tamoxifen	28-37	estrogen receptor 2	Rattus norvegicus	92-98	
25099767-8	2014	These impairments are similar as the female rats treated with the ERbeta antagonist tamoxifen (TAM).	Tamoxifen	84-93	estrogen receptor 2	Rattus norvegicus	66-72	
25099767-8	2014	These impairments are similar as the female rats treated with the ERbeta antagonist tamoxifen (TAM).	Tamoxifen	95-98	estrogen receptor 2	Rattus norvegicus	66-72	
23700476-12	2013	The significant correlation between ADC7D and ERbeta-positive cell density suggests that ERbeta may play an important role as a therapeutic indicator of tamoxifen.	Tamoxifen	153-162	estrogen receptor 2	Rattus norvegicus	89-95	
21464335-5	2011	Tamoxifen effects to increase uterine weight, decrease serum IGF-I, increase pituitary prolactin, and increase bone mineral density could be fully blocked by fulvestrant, indicating mediation by ERalpha/ERbeta.	Tamoxifen	0-9	estrogen receptor 2	Rattus norvegicus	203-209	
19138413-4	2009	Moreover, the E2 effect on IGly persisted in the presence of the calcium chelator BAPTA, the protein kinase inhibitor staurosporine, the classical ER (i.e. ERalpha and ERbeta) antagonist tamoxifen, or the G-protein modulators, favoring a direct action of E2 on GlyRs.	Tamoxifen	187-196	estrogen receptor 2	Rattus norvegicus	168-174	
19683557-5	2010	Tamoxifen attenuated ER beta-ERE association thereby acting as an estrogen antagonist at this locus.	Tamoxifen	0-9	estrogen receptor 2	Rattus norvegicus	21-28	
15846122-3	2005	Tamoxifen, 4OH and estradiol-17beta (E2) all bind to estrogen receptors (ERalpha and ERbeta), but with different affinities, suggesting that these ligands are capable of producing differential in vivo effects on the uterus.	Tamoxifen	0-9	estrogen receptor 2	Rattus norvegicus	85-91	
12834913-11	2003	Finally, TAMOX and EE had opposite effects on ERbeta mRNA expression in the paraventricular nucleus in the absence of 17beta-estradiol in group 1.	Tamoxifen	9-14	estrogen receptor 2	Rattus norvegicus	46-52	
11358690-1	2001	BACKGROUND: The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen are triphenylethylene derivatives that affect transcriptional regulation by the estrogen receptors (ERalpha and ERbeta) but show different effects in different tissues.	Tamoxifen	78-87	estrogen receptor 2	Rattus norvegicus	200-206	
12777179-12	2003	The ERalpha mRNA level was increased in the E2 treated rats, while the ERbeta mRNA level was increased after TAM treatment.	Tamoxifen	109-112	estrogen receptor 2	Rattus norvegicus	71-77	
11810032-7	2002	Tamoxifen increased ER beta mRNA levels in hypothalamus, while raloxifene increased ER beta mRNA levels in amygdala.	Tamoxifen	0-9	estrogen receptor 2	Rattus norvegicus	20-27	
11356680-6	2001	In ERbeta-transfected cells, MAPK activation was less sensitive to inhibition by tamoxifen and ICI 182,780.	Tamoxifen	81-90	estrogen receptor 2	Rattus norvegicus	3-9