PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15802375-6	2005	By contrast, expression of X-box binding protein 1 was markedly elevated in tamoxifen-treated cells in which N-CoR and SMRT had been silenced.	Tamoxifen	76-85	X-box binding protein 1	Homo sapiens	27-50	
34559986-6	2021	In particular, we demonstrate that ERalpha RNA binding mediates alternative splicing of XBP1 and translation of the eIF4G2 and MCL1 mRNAs, which facilitates survival upon stress conditions and sustains tamoxifen resistance of cancer cells.	Tamoxifen	202-211	X-box binding protein 1	Homo sapiens	88-92	
26517687-2	2015	In particular, human X-box binding protein-1(XBP1), a transcription factor which participates in UPR stress signaling, is reported to correlate with poor clinical responsiveness to tamoxifen.	Tamoxifen	181-190	X-box binding protein 1	Homo sapiens	45-49	
26517687-3	2015	In this study, we develop a tamoxifen-resistant MCF-7 cell line by treating the cell line with low concentration of tamoxifen, and we find that XBP1 is indeed up-regulated at both the mRNA and protein levels compared to normal MCF-7 cells.	Tamoxifen	28-37	X-box binding protein 1	Homo sapiens	144-148	
26517687-3	2015	In this study, we develop a tamoxifen-resistant MCF-7 cell line by treating the cell line with low concentration of tamoxifen, and we find that XBP1 is indeed up-regulated at both the mRNA and protein levels compared to normal MCF-7 cells.	Tamoxifen	116-125	X-box binding protein 1	Homo sapiens	144-148	
26517687-4	2015	STF-083010, a novel inhibitor which specifically blocks the XBP1 splicing, reestablishes tamoxifen sensitivity to resistant MCF-7 cells.	Tamoxifen	89-98	X-box binding protein 1	Homo sapiens	60-64	
26517687-0	2015	A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1.	Tamoxifen	39-48	X-box binding protein 1	Homo sapiens	109-113	
26517687-2	2015	In particular, human X-box binding protein-1(XBP1), a transcription factor which participates in UPR stress signaling, is reported to correlate with poor clinical responsiveness to tamoxifen.	Tamoxifen	181-190	X-box binding protein 1	Homo sapiens	21-44	
18386815-5	2008	XBP-1 isoforms were measured by quantitative RT-PCR in 100 primary breast cancer patients treated with adjuvant tamoxifen (including 30 ER alpha-negative cases).	Tamoxifen	112-121	X-box binding protein 1	Homo sapiens	0-5	
17660348-4	2007	Overexpression of spliced XBP1 [XBP1(S)] in ER-positive breast cancer cells leads to estrogen-independent growth and reduced sensitivity to growth inhibition induced by the antiestrogens Tamoxifen and Faslodex in a manner independent of functional p53.	Tamoxifen	187-196	X-box binding protein 1	Homo sapiens	26-30	
17660348-4	2007	Overexpression of spliced XBP1 [XBP1(S)] in ER-positive breast cancer cells leads to estrogen-independent growth and reduced sensitivity to growth inhibition induced by the antiestrogens Tamoxifen and Faslodex in a manner independent of functional p53.	Tamoxifen	187-196	X-box binding protein 1	Homo sapiens	32-39