PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28492543-0 2017 BASP1 interacts with oestrogen receptor alpha and modifies the tamoxifen response. Tamoxifen 63-72 brain abundant membrane attached signal protein 1 Homo sapiens 0-5 28492543-2 2017 Here we report that the transcriptional corepressor BASP1 interacts with ERalpha and in breast cancer cells, this interaction is enhanced by tamoxifen. Tamoxifen 141-150 brain abundant membrane attached signal protein 1 Homo sapiens 52-57 28492543-3 2017 We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. Tamoxifen 112-121 brain abundant membrane attached signal protein 1 Homo sapiens 13-18 28492543-4 2017 In all, 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1 dependent, including several genes that are associated with tamoxifen resistance. Tamoxifen 47-56 brain abundant membrane attached signal protein 1 Homo sapiens 84-89 28492543-4 2017 In all, 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1 dependent, including several genes that are associated with tamoxifen resistance. Tamoxifen 150-159 brain abundant membrane attached signal protein 1 Homo sapiens 84-89 28492543-5 2017 BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the antitumourigenic effects of tamoxifen treatment. Tamoxifen 109-118 brain abundant membrane attached signal protein 1 Homo sapiens 0-5 28492543-7 2017 Our data have identified BASP1 as an ERalpha cofactor that has a central role in the transcriptional and antitumourigenic effects of tamoxifen. Tamoxifen 133-142 brain abundant membrane attached signal protein 1 Homo sapiens 25-30