PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19187436-3 2009 Treatment of SH-SY5Y neuroblastoma cells and human embryonic kidney cells with the HSP90 inhibitors novobiocin and geldanamycin caused substantial decreases in the level of Akt in the mitochondria without affecting the level of Akt in the cytosol. Novobiocin 100-110 AKT serine/threonine kinase 1 Homo sapiens 173-176 19187436-3 2009 Treatment of SH-SY5Y neuroblastoma cells and human embryonic kidney cells with the HSP90 inhibitors novobiocin and geldanamycin caused substantial decreases in the level of Akt in the mitochondria without affecting the level of Akt in the cytosol. Novobiocin 100-110 AKT serine/threonine kinase 1 Homo sapiens 228-231 19187436-9 2009 This effect was blocked when Akt was mostly excluded from the mitochondria with novobiocin treatment. Novobiocin 80-90 AKT serine/threonine kinase 1 Homo sapiens 29-32 12586360-4 2003 Treatment of cells with novobiocin, which blocks C-terminal interaction of HSP90, disrupted HSP90 binding to Akt, induced Akt dephosphorylation and significantly reduced telomerase activity. Novobiocin 24-34 AKT serine/threonine kinase 1 Homo sapiens 109-112 12586360-4 2003 Treatment of cells with novobiocin, which blocks C-terminal interaction of HSP90, disrupted HSP90 binding to Akt, induced Akt dephosphorylation and significantly reduced telomerase activity. Novobiocin 24-34 AKT serine/threonine kinase 1 Homo sapiens 122-125 12586360-8 2003 To investigate whether the effect of novobiocin is due to the reduction of Akt or TERT phosphorylation, we overexpressed a phospho-mimetic, active Akt (T308D/S473D). Novobiocin 37-47 AKT serine/threonine kinase 1 Homo sapiens 75-78 12586360-8 2003 To investigate whether the effect of novobiocin is due to the reduction of Akt or TERT phosphorylation, we overexpressed a phospho-mimetic, active Akt (T308D/S473D). Novobiocin 37-47 AKT serine/threonine kinase 1 Homo sapiens 147-150 12586360-9 2003 Akt (T308D/S473D) prevented novobiocin-induced reduction of telomerase activity and the stimulation of apoptosis. Novobiocin 28-38 AKT serine/threonine kinase 1 Homo sapiens 0-3