PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6448580-0	1980	Transduction of methicillin resistance in Staphylococcus aureus: recipient effectiveness and beta-lactamase production.	Methicillin	16-27	beta-lactamase	Staphylococcus aureus	93-107	
646349-2	1978	However, we have found that such a strain susceptible to 0.06 mug of penicillin per ml and 0.56 mug of methicillin per ml produces beta-lactamase(s) which hydrolyzes penicillin G, methicillin, 6-aminopenicillanic acid, and probably cephaloridine.	Methicillin	103-114	beta-lactamase	Staphylococcus aureus	131-145	
646349-2	1978	However, we have found that such a strain susceptible to 0.06 mug of penicillin per ml and 0.56 mug of methicillin per ml produces beta-lactamase(s) which hydrolyzes penicillin G, methicillin, 6-aminopenicillanic acid, and probably cephaloridine.	Methicillin	180-191	beta-lactamase	Staphylococcus aureus	131-145	
1167043-3	1975	By all criteria, methicillin and nafcillin were clearly more resistant to both the inoculum effect and the production of staphylococcal beta-lactamase, whereas benzylpenicillin and cephaloridine (especially benzyl-penicillin) were the most susceptible to these effects.	Methicillin	17-28	beta-lactamase	Staphylococcus aureus	136-150	
1167043-7	1975	These results suggest that methicillin or nafcillin is most stable to staphylococcal beta-lactamase, and that benzylpenicillin and cephaloridine are the most susceptible.	Methicillin	27-38	beta-lactamase	Staphylococcus aureus	85-99	
24844761-7	2014	Moreover, by taking advantage of its high sensitivity and NIR emission feature, the probe has also been utilized to image beta-lactamase in three types of Staphylococcus aureus, including methicillin-resistant S. aureus ATCC BAA44, penicillin-resistant strain ATCC 11632, and penicillin-susceptible strain ATCC 29213, which clearly reveals the significantly different expression levels of beta-lactamase in these S. aureus.	Methicillin	188-199	beta-lactamase	Staphylococcus aureus	122-136	
23075449-2	2012	S. aureus has developed methicillin resistance mainly by expression of beta-lactamase and PBP2a, which is regulated by the blaZ-blaI-blaR1 and mecA-mecI-mecRI systems.	Methicillin	24-35	beta-lactamase	Staphylococcus aureus	71-85	
9141758-1	1996	OBJECTIVE: To determine the minimum inhibitory concentration (MIC) to methicillin and compare it with the type of methicillin resistance in methicillin resistant Staphylococcus aureus (MRSA) isolated from clinical samples, and to evaluate the usefulness of beta-lactamase resistant penicillins such as cloxacillin for treatment of minor MRSA infections.	Methicillin	70-81	beta-lactamase	Staphylococcus aureus	257-271	
8942139-1	1996	Recently isolated strains of methicillin-resistant Staphylococcus aureus (MRSA) have high levels of resistance to the agent and produce beta-lactamase less frequently than methicillin-susceptible strains (MSSA).	Methicillin	29-40	beta-lactamase	Staphylococcus aureus	136-150	
8041291-0	1994	Effect of beta-lactamase on minimum inhibitory concentrations of methicillin in methicillin-resistant Staphylococcus aureus.	Methicillin	65-76	beta-lactamase	Staphylococcus aureus	10-24	
8041291-1	1994	A study was undertaken to determine whether the production of penicillin-binding protein-2" (PBP-2") and the production of beta-lactamase were related to the minimum inhibitory concentrations of methicillin (DMPPC) in various strains of methicillin-resistant Staphylococcus aureus.	Methicillin	195-206	beta-lactamase	Staphylococcus aureus	123-137	
1507427-0	1992	[The beta-lactamase activity in methicillin-resistant Staphylococcus aureus--a comparison of the beta-lactamase from a methicillin-resistant and from a methicillin-sensitive strain of Staphylococcus aureus].	Methicillin	32-43	beta-lactamase	Staphylococcus aureus	5-19	
1507427-0	1992	[The beta-lactamase activity in methicillin-resistant Staphylococcus aureus--a comparison of the beta-lactamase from a methicillin-resistant and from a methicillin-sensitive strain of Staphylococcus aureus].	Methicillin	32-43	beta-lactamase	Staphylococcus aureus	97-111	
1507427-0	1992	[The beta-lactamase activity in methicillin-resistant Staphylococcus aureus--a comparison of the beta-lactamase from a methicillin-resistant and from a methicillin-sensitive strain of Staphylococcus aureus].	Methicillin	119-130	beta-lactamase	Staphylococcus aureus	5-19	
1507427-0	1992	[The beta-lactamase activity in methicillin-resistant Staphylococcus aureus--a comparison of the beta-lactamase from a methicillin-resistant and from a methicillin-sensitive strain of Staphylococcus aureus].	Methicillin	119-130	beta-lactamase	Staphylococcus aureus	97-111	
1507427-2	1992	In the strains of MRSA, the beta-lactamase activity tends to be inversely related to the MIC"s of Methicillin.	Methicillin	98-109	beta-lactamase	Staphylococcus aureus	28-42	
3290186-6	1988	Methicillin, a penicillin that was essentially resistant to staphylococcal beta-lactamase, was introduced into clinical use in the early 1960s and this alleviated much of the problem of antimicrobial resistance in S. aureus, but methicillin-resistant strains were soon isolated.	Methicillin	0-11	beta-lactamase	Staphylococcus aureus	75-89	
3496977-4	1987	Synthesis of novel beta-lactam derivatives from 6-APA, such as methicillin and isoxazolyl penicillins, resistant to staphylococcal beta-lactamase, overcame the clinical problem of penicillin-resistant S. aureus.	Methicillin	63-74	beta-lactamase	Staphylococcus aureus	131-145