PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28039278-1 2017 Objectives: Mycobacterium tuberculosis and Mycobacterium abscessus produce broad-spectrum class A beta-lactamases, BlaC and Bla Mab , which are inhibited by clavulanate and avibactam, respectively. Clavulanic Acid 157-168 beta-lactamase Escherichia coli 115-118 3263690-8 1988 Synergy between clavulanate or sulbactam (2 micrograms/mL) and amoxicillin was greater against derivatives producing EBS-Bla than against those producing TEM-1, TEM-2, or SHV-1; this synergy was greater with clavulanate than with sulbactam against derivatives producing SHV-2 and the SHV-2-type enzyme but was similar with clavulanate and sulbactam against those producing CTX-1. Clavulanic Acid 16-27 beta-lactamase Escherichia coli 121-124 28039278-4 2017 Methods: Enzyme kinetics were determined to assess the impact of the substitutions G 132 N in BlaC and N 132 G in Bla Mab on beta-lactamase inhibition by clavulanate and avibactam. Clavulanic Acid 154-165 beta-lactamase Escherichia coli 94-97 28039278-8 2017 Bla Mab efficiently hydrolysed clavulanate, but the substitution N 132 G led to a 5600-fold reduction in the hydrolysis rate constant k cat due to stabilization of Bla Mab -clavulanate covalent adducts. Clavulanic Acid 31-42 beta-lactamase Escherichia coli 0-3 28039278-8 2017 Bla Mab efficiently hydrolysed clavulanate, but the substitution N 132 G led to a 5600-fold reduction in the hydrolysis rate constant k cat due to stabilization of Bla Mab -clavulanate covalent adducts. Clavulanic Acid 173-184 beta-lactamase Escherichia coli 0-3 28039278-8 2017 Bla Mab efficiently hydrolysed clavulanate, but the substitution N 132 G led to a 5600-fold reduction in the hydrolysis rate constant k cat due to stabilization of Bla Mab -clavulanate covalent adducts. Clavulanic Acid 173-184 beta-lactamase Escherichia coli 164-167 18070972-6 2008 Escherichia coli harboring bla(CAD-1) exhibited resistance to penams (benzylpenicillin and amoxicillin) and remained susceptible to amoxicillin in combination with clavulanic acid. Clavulanic Acid 164-179 beta-lactamase Escherichia coli 27-30 16870757-6 2006 A recombinant Escherichia coli strain carrying the bla(FUS-1) gene exhibited resistance to amoxicillin with a moderate decrease in the MICs with clavulanic acid. Clavulanic Acid 145-160 beta-lactamase Escherichia coli 51-54