PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19816507-6	2010	Furthermore, the BH3 mimetic ABT-737, which acts through Bax/Bak, also stimulates nuclear protein redistribution in a Bax/Bak-dependent manner.	BH 3	17-20	BCL2-associated X protein	Mus musculus	57-60	
24352880-5	2014	BIM exerts its pro-death function via its alpha-helical BH3 death domain that has the dual capacity to inhibit antiapoptotic proteins such as BCL-2 and MCL-1 and directly trigger proapoptotic proteins such as the mitochondrial executioner protein BAX.	BH 3	56-59	BCL2-associated X protein	Mus musculus	247-250	
24227720-6	2013	Disruption of Bax:Bcl-xL binding by BH3-mimetic ABT 737 caused rapid apoptosis of cerebellar progenitors and primary murine medulloblastoma cells.	BH 3	36-39	BCL2-associated X protein	Mus musculus	14-17	
21247434-6	2011	The present study analyzed the interaction of calmodulin with the BH3 sequence of Bax, and the calmodulin-binding sequence of myristoylated alanine-rich C-kinase substrate in the presence of xanthurenic acid in primary retinal epithelium cell cultures and murine epithelial fibroblast cell lines transformed with SV40 (wild type [WT], Bid knockout [Bid-/-], and Bax-/-/Bak-/- double knockout [DKO]).	BH 3	66-69	BCL2-associated X protein	Mus musculus	82-85	
21127253-4	2010	Genetic deletion of Bid, Bim, and Puma prevented the homo-oligomerization of BAX and BAK, and thereby cytochrome c-mediated activation of caspases in response to diverse death signals in neurons and T lymphocytes, despite the presence of other BH3-only molecules.	BH 3	244-247	BCL2-associated X protein	Mus musculus	77-80	
20503275-0	2011	A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1.	BH 3	8-11	BCL2-associated X protein	Mus musculus	40-43	
21199865-5	2011	In both structures, Met-74 from the Bax peptide engages with the BH3-binding groove in a fifth hydrophobic interaction.	BH 3	65-68	BCL2-associated X protein	Mus musculus	36-39	
21199865-7	2011	Bax/Bak-deficient mouse embryonic fibroblast cells reconstituted with several Bax Met-74 mutants are more sensitive to the BH3 mimetic compound ABT-737 as compared with cells expressing wild-type Bax.	BH 3	123-126	BCL2-associated X protein	Mus musculus	0-3	
21199865-7	2011	Bax/Bak-deficient mouse embryonic fibroblast cells reconstituted with several Bax Met-74 mutants are more sensitive to the BH3 mimetic compound ABT-737 as compared with cells expressing wild-type Bax.	BH 3	123-126	BCL2-associated X protein	Mus musculus	78-81	
21199865-7	2011	Bax/Bak-deficient mouse embryonic fibroblast cells reconstituted with several Bax Met-74 mutants are more sensitive to the BH3 mimetic compound ABT-737 as compared with cells expressing wild-type Bax.	BH 3	123-126	BCL2-associated X protein	Mus musculus	78-81	
19951366-5	2010	These data were further supported by transfection of a mouse Bax (mBax) mutant, whose BH3 was replaced by the mBNIP-21 BH3-like domain.	BH 3	86-89	BCL2-associated X protein	Mus musculus	61-64	
19951366-5	2010	These data were further supported by transfection of a mouse Bax (mBax) mutant, whose BH3 was replaced by the mBNIP-21 BH3-like domain.	BH 3	86-89	BCL2-associated X protein	Mus musculus	66-70	
19816507-6	2010	Furthermore, the BH3 mimetic ABT-737, which acts through Bax/Bak, also stimulates nuclear protein redistribution in a Bax/Bak-dependent manner.	BH 3	17-20	BCL2-associated X protein	Mus musculus	118-121	
17097561-0	2006	The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.	BH 3	4-7	BCL2-associated X protein	Mus musculus	99-102	
17097561-2	2006	Of seven putative BH3 mimetics tested, only ABT-737 triggered Bax/Bak-mediated apoptosis.	BH 3	18-21	BCL2-associated X protein	Mus musculus	62-65	
12624178-4	2003	In contrast, targeting of BAX to mitochondria selectively restored apoptosis to "BH3-only" signals.	BH 3	81-84	BCL2-associated X protein	Mus musculus	26-29	
27159560-5	2016	Our structure-function analyses revealed that the BH3 binding capacity of MCL-1 and its suppression of BAX are impaired by molecular engagement, a phenomenon recapitulated by C286W mutagenic mimicry in vitro and in mouse cells.	BH 3	50-53	BCL2-associated X protein	Mus musculus	103-106	
25715028-3	2015	Here we report that the BH3 mimetic, ABT-737, induces autophagy in parallel with disruption of BCL2-BECN1 binding in 2 different apoptosis-deficient cell types lacking BAX and BAK1, namely in mouse embryonic fibroblasts cells and in human colon cancer HCT116 cells.	BH 3	24-27	BCL2-associated X protein	Mus musculus	168-171	
17404107-4	2007	One such lead compound is the benzenesulfonyl derivative TW-37, which was designed to target the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins, such as Bak, Bax, Bid, and Bim bind.	BH 3	97-100	BCL2-associated X protein	Mus musculus	173-176	
25862283-6	2015	Interestingly, cells overexpressing Bcl-xL were more sensitive to apoptosis upon treatment with the BH3-mimetic ABT-737, suggesting that despite its role in Bax inhibition, Bcl-xL also primes mitochondria to permeabilization and cytochrome c release.	BH 3	100-103	BCL2-associated X protein	Mus musculus	157-160