PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30428424-8 2019 RESULTS: Incubation with EPA and/or DHA attenuated inflammatory response to lipopolysaccharide (LPS) and monocyte co-culture with reduction in post-LPS mRNA expression and protein levels of IL6, CCL2 and CX3CL1. Docosahexaenoic Acids 36-39 C-C motif chemokine ligand 2 Homo sapiens 195-199 32058033-9 2020 EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8. Docosahexaenoic Acids 8-11 C-C motif chemokine ligand 2 Homo sapiens 53-87 30191990-5 2019 LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2 (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr). Docosahexaenoic Acids 4-7 C-C motif chemokine ligand 2 Homo sapiens 148-178 30191990-5 2019 LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2 (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr). Docosahexaenoic Acids 4-7 C-C motif chemokine ligand 2 Homo sapiens 181-185 33303222-5 2021 EPA lowered TNFA (p < 0.001) whereas DHA reduced TNFA (p < 0.001), IL6 (p < 0.02), MCP1 (p < 0.03), and IL10 (p < 0.01). Docosahexaenoic Acids 37-40 C-C motif chemokine ligand 2 Homo sapiens 83-87 29471285-10 2018 SAT inflammation-related gene expression (Tumor necrosis factor alpha [TNF-alpha], and monocyte chemoattractant protein-1 [MCP-1]) significantly decreased in the DHA group. Docosahexaenoic Acids 162-165 C-C motif chemokine ligand 2 Homo sapiens 87-121 28835131-7 2018 DHA slightly countered the actions of IL-1beta on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 50-54 29471285-10 2018 SAT inflammation-related gene expression (Tumor necrosis factor alpha [TNF-alpha], and monocyte chemoattractant protein-1 [MCP-1]) significantly decreased in the DHA group. Docosahexaenoic Acids 162-165 C-C motif chemokine ligand 2 Homo sapiens 123-128 27044314-3 2016 The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages. Docosahexaenoic Acids 81-84 C-C motif chemokine ligand 2 Homo sapiens 149-153 28838848-6 2017 Moreover, EPA and DHA pretreatment diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. Docosahexaenoic Acids 18-21 C-C motif chemokine ligand 2 Homo sapiens 56-90 28838848-6 2017 Moreover, EPA and DHA pretreatment diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. Docosahexaenoic Acids 18-21 C-C motif chemokine ligand 2 Homo sapiens 92-97 27044314-7 2016 Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1. Docosahexaenoic Acids 56-59 C-C motif chemokine ligand 2 Homo sapiens 119-123 27044314-7 2016 Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1. Docosahexaenoic Acids 42-45 C-C motif chemokine ligand 2 Homo sapiens 119-123 25044948-1 2014 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Docosahexaenoic Acids 30-50 C-C motif chemokine ligand 2 Homo sapiens 98-138 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 109-143 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 145-150 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 151-155 25629558-9 2015 However, only DHA and DHA/ARA exerted a potentanti-inflammatory effect reflected by prevention of tumor necrosis factor-alpha (TNF-alpha) induced NF-kappaB activation and MCP-1 secretion in human adipocytes. Docosahexaenoic Acids 14-17 C-C motif chemokine ligand 2 Homo sapiens 171-176 25629558-9 2015 However, only DHA and DHA/ARA exerted a potentanti-inflammatory effect reflected by prevention of tumor necrosis factor-alpha (TNF-alpha) induced NF-kappaB activation and MCP-1 secretion in human adipocytes. Docosahexaenoic Acids 22-25 C-C motif chemokine ligand 2 Homo sapiens 171-176 25044948-0 2014 Docosahexaenoic acid reduces linoleic acid induced monocyte chemoattractant protein-1 expression via PPARgamma and nuclear factor-kappaB pathway in retinal pigment epithelial cells. Docosahexaenoic Acids 0-20 C-C motif chemokine ligand 2 Homo sapiens 51-85 25044948-1 2014 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Docosahexaenoic Acids 52-55 C-C motif chemokine ligand 2 Homo sapiens 98-138 25044948-5 2014 DHA at 50 and 100 muM effectively inhibited LA-induced MCP-1 expression and production (p < 0.05) and NF-kappaB activation. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 55-60 25044948-9 2014 CONCLUSION: DHA reduced LA-induced MCP-1 expression via a PPARgamma- and NF-kappaB-dependent pathway in ARPE-19 cells. Docosahexaenoic Acids 12-15 C-C motif chemokine ligand 2 Homo sapiens 35-40 15698426-10 2005 RESULTS: Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 (MCP-1) expression. Docosahexaenoic Acids 22-25 C-C motif chemokine ligand 2 Homo sapiens 181-215 22013115-6 2011 This shift was confined to the SVC fraction, in which secretion of Th1 cytokines (IL-6, MCP-1, and TNF-alpha) was blocked by DHA. Docosahexaenoic Acids 125-128 C-C motif chemokine ligand 2 Homo sapiens 88-93 15698426-10 2005 RESULTS: Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 (MCP-1) expression. Docosahexaenoic Acids 22-25 C-C motif chemokine ligand 2 Homo sapiens 217-222