PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32199223-7 2020 Moreover, our findings indicate that Abeta25-35 activated the ERK1/2 and p38 signaling pathways, but not NF-kappaB/p65 signaling, while pre-treatment with DHA followed by Abeta25-35 treatment suppressed only ERK1/2 signaling. Docosahexaenoic Acids 155-158 mitogen-activated protein kinase 1 Homo sapiens 73-76 34571936-7 2021 Pathways of necroptosis, ferroptosis, p53, NRF2, ATF4, WNT, MAPK, NF-kappaB, EGFR, and ERK may be connected to the tumor suppressive effect caused by pretreatment of DHA/EPA prior to bortezomib. Docosahexaenoic Acids 166-169 mitogen-activated protein kinase 1 Homo sapiens 87-90 30054857-5 2019 It was observed that a sustained activation of the extracellular signal-regulated kinase (ERK) appeared to be critical for DHA-induced differentiation of the cultured astrocytes. Docosahexaenoic Acids 123-126 mitogen-activated protein kinase 1 Homo sapiens 51-88 32141512-0 2020 DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cells. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 72-75 32141512-16 2020 These results indicate that GREM1-ERK axis plays a role in EMT in human breast cancer cells and DHA is a putative compound that can inhibit EMT by inhibiting GREM1 signal transduction. Docosahexaenoic Acids 96-99 mitogen-activated protein kinase 1 Homo sapiens 34-37 32132133-11 2020 Here, we reveal the mechanisms of docosahexaenoic acid-induced phosphorylation of FFA4-L and subsequent beta-arrestin-2 recruitment and extracellular-signal regulated kinase-1/2 activity. Docosahexaenoic Acids 34-54 mitogen-activated protein kinase 1 Homo sapiens 136-177 31819534-6 2019 Moreover, the elevation of phosphorylation levels of EGFR and the downstream extracellular signal-regulated kinase (ERK) in the cellular lysates were induced by the DHA+Gefitinib treatment. Docosahexaenoic Acids 165-168 mitogen-activated protein kinase 1 Homo sapiens 77-114 31819534-6 2019 Moreover, the elevation of phosphorylation levels of EGFR and the downstream extracellular signal-regulated kinase (ERK) in the cellular lysates were induced by the DHA+Gefitinib treatment. Docosahexaenoic Acids 165-168 mitogen-activated protein kinase 1 Homo sapiens 116-119 30054857-5 2019 It was observed that a sustained activation of the extracellular signal-regulated kinase (ERK) appeared to be critical for DHA-induced differentiation of the cultured astrocytes. Docosahexaenoic Acids 123-126 mitogen-activated protein kinase 1 Homo sapiens 90-93 30054857-6 2019 Prior exposure to different endocytic inhibitors blocked both ERK activation and differentiation of the astrocytes during DHA treatment suggesting that the observed induction of ERK-2 was purely endosomal. Docosahexaenoic Acids 122-125 mitogen-activated protein kinase 1 Homo sapiens 62-65 30054857-6 2019 Prior exposure to different endocytic inhibitors blocked both ERK activation and differentiation of the astrocytes during DHA treatment suggesting that the observed induction of ERK-2 was purely endosomal. Docosahexaenoic Acids 122-125 mitogen-activated protein kinase 1 Homo sapiens 178-183 30054857-10 2019 Altogether, the observations suggest that DHA upregulates beta2-AR in astrocytes, which undergo endocytosis and signals for sustained endosomal ERK activation to drive the differentiation process. Docosahexaenoic Acids 42-45 mitogen-activated protein kinase 1 Homo sapiens 144-147 30917119-6 2019 We also show that inhibition of extracellular signal-regulated kinase 2 and exocyst complex component 70, a substrate of extracellular signal-regulated kinase 2 and mediator of secretory vesicle exocytosis, potently inhibits basal and docosahexaenoic acid-stimulated neurotensin secretion, whereas overexpression of exocyst complex component 70 enhances basal and docosahexaenoic acid-stimulated neurotensin secretion. Docosahexaenoic Acids 235-255 mitogen-activated protein kinase 1 Homo sapiens 32-71 30917119-6 2019 We also show that inhibition of extracellular signal-regulated kinase 2 and exocyst complex component 70, a substrate of extracellular signal-regulated kinase 2 and mediator of secretory vesicle exocytosis, potently inhibits basal and docosahexaenoic acid-stimulated neurotensin secretion, whereas overexpression of exocyst complex component 70 enhances basal and docosahexaenoic acid-stimulated neurotensin secretion. Docosahexaenoic Acids 235-255 mitogen-activated protein kinase 1 Homo sapiens 121-160 30917119-6 2019 We also show that inhibition of extracellular signal-regulated kinase 2 and exocyst complex component 70, a substrate of extracellular signal-regulated kinase 2 and mediator of secretory vesicle exocytosis, potently inhibits basal and docosahexaenoic acid-stimulated neurotensin secretion, whereas overexpression of exocyst complex component 70 enhances basal and docosahexaenoic acid-stimulated neurotensin secretion. Docosahexaenoic Acids 364-384 mitogen-activated protein kinase 1 Homo sapiens 32-71 30917119-6 2019 We also show that inhibition of extracellular signal-regulated kinase 2 and exocyst complex component 70, a substrate of extracellular signal-regulated kinase 2 and mediator of secretory vesicle exocytosis, potently inhibits basal and docosahexaenoic acid-stimulated neurotensin secretion, whereas overexpression of exocyst complex component 70 enhances basal and docosahexaenoic acid-stimulated neurotensin secretion. Docosahexaenoic Acids 364-384 mitogen-activated protein kinase 1 Homo sapiens 121-160 31261155-7 2019 In contrast, DHA inhibits the expression of IL-1beta, inhibits IL-1beta-induced cell apoptosis, and has a certain inhibitory effect on the activation of the MAPK signaling pathway. Docosahexaenoic Acids 13-16 mitogen-activated protein kinase 1 Homo sapiens 157-161 31261155-8 2019 When the MAPK signaling pathway is inhibited by its inhibitors, the effects of DHA on SW1353 cells are weakened. Docosahexaenoic Acids 79-82 mitogen-activated protein kinase 1 Homo sapiens 9-13 31261155-9 2019 Thus, DHA enhances the apoptosis of SW1353 cells through the MAPK signaling pathway. Docosahexaenoic Acids 6-9 mitogen-activated protein kinase 1 Homo sapiens 61-65 26204250-9 2015 DHA activates the retinoid X receptor (RXR) and the ERK/MAPK pathway, thus regulating the expression of anti and pro-apoptotic proteins. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 52-55 28647405-6 2017 In addition, both PGZ and DHA induced the phosphorylation of extracellular signal-regulated-kinase 1-2 (ERK1/2), in a PPAR-gamma-dependent manner. Docosahexaenoic Acids 26-29 mitogen-activated protein kinase 1 Homo sapiens 61-102 31261155-0 2019 Anti-Apoptotic Effects of Docosahexaenoic Acid in IL-1beta-Induced Human Chondrosarcoma Cell Death through Involvement of the MAPK Signaling Pathway. Docosahexaenoic Acids 26-46 mitogen-activated protein kinase 1 Homo sapiens 126-130 26577385-0 2016 Docosahexaenoic acid inhibits inflammation via free fatty acid receptor FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 expression in EA.hy926 cells. Docosahexaenoic Acids 0-20 mitogen-activated protein kinase 1 Homo sapiens 146-149 26577385-7 2016 Pretreatment with DHA attenuated TNF-alpha-induced phosphorylation of ERK, expression of Egr-1 and ICAM-1 and HL-60 cell adhesion. Docosahexaenoic Acids 18-21 mitogen-activated protein kinase 1 Homo sapiens 70-73 26577385-9 2016 CONCLUSION: Our results suggest that the anti-inflammatory effect of DHA on the endothelium is at least partially linked to FFA4, disruption of TAB2 interaction with TAK1/TAB1 and downregulation of ERK-dependent Egr-1 and ICAM-1 expression, which leads to less HL-60 cell adhesion to TNF-alpha-stimulated EA.hy926 cells. Docosahexaenoic Acids 69-72 mitogen-activated protein kinase 1 Homo sapiens 198-201 26204250-9 2015 DHA activates the retinoid X receptor (RXR) and the ERK/MAPK pathway, thus regulating the expression of anti and pro-apoptotic proteins. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 56-60 25133540-4 2014 Relaxations to EPA:DHA 6:1 were insensitive to cyclooxygenase inhibition, and reduced by inhibitors of either oxidative stress, Src kinase, PI3-kinase, p38 MAPK, MEK, or JNK. Docosahexaenoic Acids 19-22 mitogen-activated protein kinase 1 Homo sapiens 156-160 26163453-6 2015 However, DHA increased the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2), but not of other mitogen-activated protein kinases such as p38 and JNK. Docosahexaenoic Acids 9-12 mitogen-activated protein kinase 1 Homo sapiens 41-87 25133540-5 2014 EPA:DHA 6:1 induced phosphorylation of Src, Akt, p38 MAPK, ERK, JNK and eNOS; these effects were inhibited by MnTMPyP. Docosahexaenoic Acids 4-7 mitogen-activated protein kinase 1 Homo sapiens 53-57 25133540-5 2014 EPA:DHA 6:1 induced phosphorylation of Src, Akt, p38 MAPK, ERK, JNK and eNOS; these effects were inhibited by MnTMPyP. Docosahexaenoic Acids 4-7 mitogen-activated protein kinase 1 Homo sapiens 59-62 24993937-8 2014 DHA-induced apoptosis was coupled to the activation of the conventional MAPKs, and knockdown of ERK/JNK/p38 by small interfering RNAs reduced the apoptosis induced by DHA, indicating that the pro-apoptotic effect of DHA is mediated by MAPKs activation. Docosahexaenoic Acids 167-170 mitogen-activated protein kinase 1 Homo sapiens 96-99 24993937-8 2014 DHA-induced apoptosis was coupled to the activation of the conventional MAPKs, and knockdown of ERK/JNK/p38 by small interfering RNAs reduced the apoptosis induced by DHA, indicating that the pro-apoptotic effect of DHA is mediated by MAPKs activation. Docosahexaenoic Acids 167-170 mitogen-activated protein kinase 1 Homo sapiens 96-99 22221673-3 2012 This study investigated the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the MEK/ERK pathway and urokinase plasminogen activator receptor (uPAR) in relation to SMC migration. Docosahexaenoic Acids 93-96 mitogen-activated protein kinase 1 Homo sapiens 109-112 24457065-12 2014 DHA also up-regulated the phosphorylation of p38 and ERK, and dramatically inhibited nuclear translocation of NF-kappaB-p65 in VSMCs. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 53-56 22901690-6 2013 DHA activated Akt, p38 and ERK1/2 phosphorylation, and specific inhibitors of respective pathways attenuated DHA-induced Nrf2 nuclear translocation and HO-1 expression. Docosahexaenoic Acids 109-112 mitogen-activated protein kinase 1 Homo sapiens 19-22 22221673-6 2012 DHA also inhibited the activation of the MEK/ERK signaling pathway, whereas EPA switched the SMC phenotype from synthetic to contractile. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 45-48 22221673-9 2012 Our results suggest that n-3 LCPUFAs decrease SMC migration through the inhibition of uPAR expression, with DHA affecting its expression via the modulation of MEK/ERK signaling pathway, while EPA induces a change in SMC phenotype. Docosahexaenoic Acids 108-111 mitogen-activated protein kinase 1 Homo sapiens 163-166 20668435-6 2010 In addition, DHA caused AKT and ERK activation in a time-dependent manner, and the DHA-induced HO-1 upregulation could be attenuated by PI-3 kinase/AKT and MEK/ERK inhibitors. Docosahexaenoic Acids 13-16 mitogen-activated protein kinase 1 Homo sapiens 32-35 22285823-6 2012 Additionally, DHA and EPA attenuated expression of macrophage-activated extracellular-signal-regulated kinase (ERK) and signal transducers and activators of transcription 3 (STAT3) in cancer cells. Docosahexaenoic Acids 14-17 mitogen-activated protein kinase 1 Homo sapiens 72-109 22285823-6 2012 Additionally, DHA and EPA attenuated expression of macrophage-activated extracellular-signal-regulated kinase (ERK) and signal transducers and activators of transcription 3 (STAT3) in cancer cells. Docosahexaenoic Acids 14-17 mitogen-activated protein kinase 1 Homo sapiens 111-114 21771724-4 2011 In MCF-7 cells and SK-BR-3 cells, DHA and a SDC-1 ectodomain impaired signaling of the p44/42 mitogen-activated protein kinase (MAPK) pathway by inhibiting the phosphorylation of MAPK/Erk (MEK)/extracellular signal-regulated kinase (Erk) and Bad to induce apoptosis. Docosahexaenoic Acids 34-37 mitogen-activated protein kinase 1 Homo sapiens 128-132 21771724-4 2011 In MCF-7 cells and SK-BR-3 cells, DHA and a SDC-1 ectodomain impaired signaling of the p44/42 mitogen-activated protein kinase (MAPK) pathway by inhibiting the phosphorylation of MAPK/Erk (MEK)/extracellular signal-regulated kinase (Erk) and Bad to induce apoptosis. Docosahexaenoic Acids 34-37 mitogen-activated protein kinase 1 Homo sapiens 179-183 21771724-4 2011 In MCF-7 cells and SK-BR-3 cells, DHA and a SDC-1 ectodomain impaired signaling of the p44/42 mitogen-activated protein kinase (MAPK) pathway by inhibiting the phosphorylation of MAPK/Erk (MEK)/extracellular signal-regulated kinase (Erk) and Bad to induce apoptosis. Docosahexaenoic Acids 34-37 mitogen-activated protein kinase 1 Homo sapiens 184-187 21771724-4 2011 In MCF-7 cells and SK-BR-3 cells, DHA and a SDC-1 ectodomain impaired signaling of the p44/42 mitogen-activated protein kinase (MAPK) pathway by inhibiting the phosphorylation of MAPK/Erk (MEK)/extracellular signal-regulated kinase (Erk) and Bad to induce apoptosis. Docosahexaenoic Acids 34-37 mitogen-activated protein kinase 1 Homo sapiens 233-236 21771724-9 2011 These data elucidate a pathway whereby SDC-1, upregulated by DHA, induces apoptosis in breast cancer cells through inhibition of MEK/Erk/Bad signaling. Docosahexaenoic Acids 61-64 mitogen-activated protein kinase 1 Homo sapiens 133-136 20668435-6 2010 In addition, DHA caused AKT and ERK activation in a time-dependent manner, and the DHA-induced HO-1 upregulation could be attenuated by PI-3 kinase/AKT and MEK/ERK inhibitors. Docosahexaenoic Acids 13-16 mitogen-activated protein kinase 1 Homo sapiens 160-163 20668435-6 2010 In addition, DHA caused AKT and ERK activation in a time-dependent manner, and the DHA-induced HO-1 upregulation could be attenuated by PI-3 kinase/AKT and MEK/ERK inhibitors. Docosahexaenoic Acids 83-86 mitogen-activated protein kinase 1 Homo sapiens 160-163 20525880-5 2010 Previous reports have noted changes in membrane microdomains upon DHA supplementation, and our findings confirmed that EGFR, but not Ras, is excluded from caveolin-rich lipid raft fractions in DHA-treated cells, resulting in a decreased association of Ras with Sos1 and the subsequent downregulation of Erk signaling. Docosahexaenoic Acids 193-196 mitogen-activated protein kinase 1 Homo sapiens 303-306 19723051-5 2009 We found that DHA induced cell death and DNA fragmentation in parallel with the activation of extracellular signal-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) as well as AP-1. Docosahexaenoic Acids 14-17 mitogen-activated protein kinase 1 Homo sapiens 94-132 19723051-5 2009 We found that DHA induced cell death and DNA fragmentation in parallel with the activation of extracellular signal-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) as well as AP-1. Docosahexaenoic Acids 14-17 mitogen-activated protein kinase 1 Homo sapiens 134-137 19723051-8 2009 Because JNK and ERK are upstream signaling for AP-1 activation, we suggest that DHA-induced activation of AP-1 may mediate apoptosis of gastric cancer cells by inducing the expression of apoptotic genes in gastric cancer cells. Docosahexaenoic Acids 80-83 mitogen-activated protein kinase 1 Homo sapiens 16-19 18679798-0 2008 Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression. Docosahexaenoic Acids 0-20 mitogen-activated protein kinase 1 Homo sapiens 115-118 15094063-1 2004 This study was conducted on human Jurkat T-cells to investigate the role of depletion of intracellular Ca(2+) stores in the phosphorylation of two mitogen-activated protein kinases (MAPKs), i.e. extracellular signal-regulated kinase (ERK) 1 and ERK2, and their modulation by a polyunsaturated fatty acid, docosahexaenoic acid (DHA). Docosahexaenoic Acids 305-325 mitogen-activated protein kinase 1 Homo sapiens 195-240 18679798-7 2008 DHA reduced also the levels of the phosphorylated MAP-kinases, especially ERK1/2 and p38. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 85-88 16616699-5 2006 We observed that EPA or DHA alone significantly reduced the TNF-alpha-induced activation of p38 and JNK kinases at a concentration of 20 microM, but EPA is a more potent inhibitor than DHA. Docosahexaenoic Acids 24-27 mitogen-activated protein kinase 1 Homo sapiens 92-95 16616699-7 2006 Meanwhile, both EPA and DHA significantly attenuated the TNF-alpha-induced expression of p38 and ERK1/2 mRNA, and DHA but not EPA also reduced the TNF-alpha-induced JNK mRNA expression. Docosahexaenoic Acids 24-27 mitogen-activated protein kinase 1 Homo sapiens 89-92 16616699-8 2006 We present data show that both EPA and DHA alone diminish activation of p38 and JNK kinases, while maintaining the activation of ERK1/2 kinases of TNF-alpha-stimulated HUVEC. Docosahexaenoic Acids 39-42 mitogen-activated protein kinase 1 Homo sapiens 72-75 16300635-5 2006 DHA pre-treatment was observed to significantly increase neuronal survival upon Abeta treatment by preventing cytoskeleton perturbations, caspase activation and apoptosis, as well as by promoting extracellular signal-related kinase (ERK)-related survival pathways. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 196-231 16300635-5 2006 DHA pre-treatment was observed to significantly increase neuronal survival upon Abeta treatment by preventing cytoskeleton perturbations, caspase activation and apoptosis, as well as by promoting extracellular signal-related kinase (ERK)-related survival pathways. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 233-236 16923163-0 2006 Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. Docosahexaenoic Acids 0-20 mitogen-activated protein kinase 1 Homo sapiens 83-86 16923163-0 2006 Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway. Docosahexaenoic Acids 0-20 mitogen-activated protein kinase 1 Homo sapiens 87-91 16923163-6 2006 DHA rapidly increased ERK phosphorylation in photoreceptors, whereas U0126 blocked this increase. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 22-25 16923163-10 2006 These results suggest that DHA exclusively activates the ERK/MAPK pathway to promote photoreceptor survival during early development in vitro and upon oxidative stress. Docosahexaenoic Acids 27-30 mitogen-activated protein kinase 1 Homo sapiens 57-60 16923163-10 2006 These results suggest that DHA exclusively activates the ERK/MAPK pathway to promote photoreceptor survival during early development in vitro and upon oxidative stress. Docosahexaenoic Acids 27-30 mitogen-activated protein kinase 1 Homo sapiens 61-65 15735744-3 2005 DHA demonstrated a tendency to stimulate cell growth at low doses and induce apoptosis at high doses, paralleled by the activation of ERK and caspase-3. Docosahexaenoic Acids 0-3 mitogen-activated protein kinase 1 Homo sapiens 134-137 15094063-1 2004 This study was conducted on human Jurkat T-cells to investigate the role of depletion of intracellular Ca(2+) stores in the phosphorylation of two mitogen-activated protein kinases (MAPKs), i.e. extracellular signal-regulated kinase (ERK) 1 and ERK2, and their modulation by a polyunsaturated fatty acid, docosahexaenoic acid (DHA). Docosahexaenoic Acids 327-330 mitogen-activated protein kinase 1 Homo sapiens 195-240 15094063-6 2004 Furthermore, DHA seems to act by inhibiting PKC activation as this fatty acid diminished TG- and phorbol 12-myristate 13-acetate-induced ERK1/ERK2 phosphorylation in these cells. Docosahexaenoic Acids 13-16 mitogen-activated protein kinase 1 Homo sapiens 142-146 11734574-0 2001 Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. Docosahexaenoic Acids 26-46 mitogen-activated protein kinase 1 Homo sapiens 73-77