PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12428761-2 2002 Hypoxia/ischemia triggers phospholipase A2, leading to the accumulation of free arachidonic and docosahexaenoic acids (AA, DHA), as well as that of lysophospholipids. Docosahexaenoic Acids 96-117 phospholipase A2 group IB Homo sapiens 26-42 9841872-3 1998 Exogenous eicosatetraenoic acid [arachidonic acid; C20:4(n-6)] or docosahexaenoic acid [C22:6(n-3)] promoted the release of [3H]C20:4(n-6) from prelabelled neutrophils in a time- and dose-dependent manner, which is indicative of PLA2 activation. Docosahexaenoic Acids 66-86 phospholipase A2 group IB Homo sapiens 229-233 33263931-2 2020 Cytokines/chemokines excite phospholipase A2 and cyclooxygenases (COX), facilitating the release of arachidonic acid (AA) and docosahexaenoic acid (DHA) from membrane glycerophospholipids, in which the former is oxidized to produce pro-inflammatory eicosanoids (prostaglandins, leukotrienes and thromboxane"s), which intensify the neuroinflammatory events in the brain. Docosahexaenoic Acids 126-146 phospholipase A2 group IB Homo sapiens 28-44 1533163-0 1992 The hydrolysis of natural phosphatidylethanolamines by phospholipase A2 from rat serum: a degree of selectivity is shown for docosahexaenoate release. Docosahexaenoic Acids 125-141 phospholipase A2 group IB Homo sapiens 55-71 1533163-8 1992 This preferential release of docosahexaenoate by serum phospholipase A2 is of considerable significance in the nervous system which is enriched in this polyunsaturate. Docosahexaenoic Acids 29-45 phospholipase A2 group IB Homo sapiens 55-71 33263931-2 2020 Cytokines/chemokines excite phospholipase A2 and cyclooxygenases (COX), facilitating the release of arachidonic acid (AA) and docosahexaenoic acid (DHA) from membrane glycerophospholipids, in which the former is oxidized to produce pro-inflammatory eicosanoids (prostaglandins, leukotrienes and thromboxane"s), which intensify the neuroinflammatory events in the brain. Docosahexaenoic Acids 148-151 phospholipase A2 group IB Homo sapiens 28-44 28648567-0 2018 Eicosapentaenoic and docosahexaenoic acids have different effects on peripheral phospholipase A2 gene expressions in acute depressed patients. Docosahexaenoic Acids 21-42 phospholipase A2 group IB Homo sapiens 80-96 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). Docosahexaenoic Acids 69-89 phospholipase A2 group IB Homo sapiens 164-180 30866528-5 2019 DHA had an effect on the levels of both the intracellular and secreted activities of PLA2 and PAFAH. Docosahexaenoic Acids 0-3 phospholipase A2 group IB Homo sapiens 85-89 28648567-3 2018 METHODS: We conducted a 12-week randomized-controlled trial comparing the effects of EPA and DHA on gene expressions of phospholipase A2 (cPLA2) and cyclooxygenase-2 (COX2), serotonin transporter (5HTT), and Tryptophan hydroxylase 2 (TPH-2) in 27 MDD patients. Docosahexaenoic Acids 93-96 phospholipase A2 group IB Homo sapiens 120-136 22178644-1 2012 The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes. Docosahexaenoic Acids 76-96 phospholipase A2 group IB Homo sapiens 242-260 23604781-2 2013 A model for delivering dietary sn-2-DHA phosphatidylcholine (PtdCho) to the brain involves phospholipase A2 based deacylation/reacylation cycle followed by delivery of DHA through high-density lipoproteins that bind to the brain capillary endothelial cells in the blood-brain barrier (BBB). Docosahexaenoic Acids 36-39 phospholipase A2 group IB Homo sapiens 91-107 23604781-6 2013 The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB. Docosahexaenoic Acids 155-158 phospholipase A2 group IB Homo sapiens 57-61 23604781-6 2013 The data presented here show that: (1) group X secretory PLA2 (sPLA2) is about threefold more active than group V sPLA2 in releasing sn-2 fatty acids from DHA regioisomers, and (2) EL shows its specificity for DHA PtdCho species in a concentration independent manner, suggesting that the enzyme could play a major role in generating free sn-1-DHA or/and sn-2-DHA lysoPtdCho from the regioisomers in the BBB. Docosahexaenoic Acids 210-213 phospholipase A2 group IB Homo sapiens 57-61 22178644-1 2012 The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes. Docosahexaenoic Acids 76-96 phospholipase A2 group IB Homo sapiens 262-268 22178644-1 2012 The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes. Docosahexaenoic Acids 98-101 phospholipase A2 group IB Homo sapiens 242-260 22178644-1 2012 The polyunsaturated fatty acids (PUFAs), arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3), important second messengers in brain, are released from membrane phospholipid following receptor-mediated activation of specific phospholipase A(2) (PLA(2)) enzymes. Docosahexaenoic Acids 98-101 phospholipase A2 group IB Homo sapiens 262-268 20034614-8 2010 CONCLUSIONS: Genetic variations in the COX2 and PLA2 genes increase the risk of IFN-alpha-induced depression, possibly by affecting the levels of EPA and DHA. Docosahexaenoic Acids 154-157 phospholipase A2 group IB Homo sapiens 48-52 21703303-5 2011 Degradation of GPs by phospholipase A(2) can release two important brain polyunsaturated fatty acids (PUFAs), e.g., arachidonic acid and docosahexaenoic acid, linked together by a delicate equilibrium. Docosahexaenoic Acids 137-157 phospholipase A2 group IB Homo sapiens 22-39 17393491-3 2007 Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA). Docosahexaenoic Acids 103-124 phospholipase A2 group IB Homo sapiens 39-57 18252846-0 2008 The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids. Docosahexaenoic Acids 80-100 phospholipase A2 group IB Homo sapiens 50-66 19022981-1 2008 Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-CoA synthetase enzymes that regulate turnover are specific for one or the other PUFA. Docosahexaenoic Acids 102-122 phospholipase A2 group IB Homo sapiens 201-219 19022981-1 2008 Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-CoA synthetase enzymes that regulate turnover are specific for one or the other PUFA. Docosahexaenoic Acids 102-122 phospholipase A2 group IB Homo sapiens 221-227 19022981-1 2008 Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-CoA synthetase enzymes that regulate turnover are specific for one or the other PUFA. Docosahexaenoic Acids 124-127 phospholipase A2 group IB Homo sapiens 201-219 19022981-1 2008 Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-CoA synthetase enzymes that regulate turnover are specific for one or the other PUFA. Docosahexaenoic Acids 124-127 phospholipase A2 group IB Homo sapiens 221-227 17393491-3 2007 Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA). Docosahexaenoic Acids 103-124 phospholipase A2 group IB Homo sapiens 59-65 17393491-3 2007 Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA). Docosahexaenoic Acids 126-129 phospholipase A2 group IB Homo sapiens 39-57 17393491-3 2007 Degradation of glycerophospholipids by phospholipase A(2) (PLA(2)) generates arachidonic acid (AA) and docosahexaenoic acids (DHA). Docosahexaenoic Acids 126-129 phospholipase A2 group IB Homo sapiens 59-65 15627650-3 2005 Furthermore, two isoforms of phospholipase A(2) (i.e., calcium-dependent and calcium-independent) were implicated in the release of DHA and EPA, respectively, during activation of these cells. Docosahexaenoic Acids 132-135 phospholipase A2 group IB Homo sapiens 29-47 16684969-1 2006 Phospholipase A2 (PLA2) generates arachidonic acid, docosahexaenoic acid, and lysophospholipids from neural membrane phospholipids. Docosahexaenoic Acids 52-72 phospholipase A2 group IB Homo sapiens 0-16 16684969-1 2006 Phospholipase A2 (PLA2) generates arachidonic acid, docosahexaenoic acid, and lysophospholipids from neural membrane phospholipids. Docosahexaenoic Acids 52-72 phospholipase A2 group IB Homo sapiens 18-22 15912889-1 2005 The biosynthesis of oxygenated arachidonic acid messengers triggered by cerebral ischemia-reperfusion is preceded by an early and rapid phospholipase A2 activation reflected in free arachidonic and docosahexaenoic acid (DHA) accumulation. Docosahexaenoic Acids 198-218 phospholipase A2 group IB Homo sapiens 136-152 15912889-1 2005 The biosynthesis of oxygenated arachidonic acid messengers triggered by cerebral ischemia-reperfusion is preceded by an early and rapid phospholipase A2 activation reflected in free arachidonic and docosahexaenoic acid (DHA) accumulation. Docosahexaenoic Acids 220-223 phospholipase A2 group IB Homo sapiens 136-152 15912889-10 2005 A time-dependent release of endogenous free DHA followed by NPD1 formation occurs, suggesting that a phospholipase A2 releases the mediator"s precursor. Docosahexaenoic Acids 44-47 phospholipase A2 group IB Homo sapiens 101-117 15627650-6 2005 Together, these results demonstrate that DHA and EPA, being released by two isoforms of phospholipase A(2), modulate IL-2 gene expression by exerting their action on two PKC isoforms and NF-kappaB in Jurkat T-cells. Docosahexaenoic Acids 41-44 phospholipase A2 group IB Homo sapiens 88-106 15465285-11 2004 Our recently obtained data revealed that the release of arachidonic and docosahexaenoic acids in astrocytes is controlled by different isoforms of phospholipase A(2), i.e. Ca(2+)-dependent phospholipase A(2) and Ca(2+)-independent phospholipase A(2), respectively. Docosahexaenoic Acids 72-93 phospholipase A2 group IB Homo sapiens 147-164 15465285-11 2004 Our recently obtained data revealed that the release of arachidonic and docosahexaenoic acids in astrocytes is controlled by different isoforms of phospholipase A(2), i.e. Ca(2+)-dependent phospholipase A(2) and Ca(2+)-independent phospholipase A(2), respectively. Docosahexaenoic Acids 72-93 phospholipase A2 group IB Homo sapiens 189-206 15152078-6 2004 Under these conditions, there is a time-dependent release of endogenous free DHA followed by NPD1 formation, suggesting that phospholipase A(2) releases the mediator"s precursor. Docosahexaenoic Acids 77-80 phospholipase A2 group IB Homo sapiens 125-143