PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18033239-5 2008 The PPARalpha activator docosahexaenoic acid given to gentamicin-treated mice significantly reduced the number of apoptotic cells in renal cortex, but this protective effect was not seen in PPARalpha knockout mice. Docosahexaenoic Acids 24-44 peroxisome proliferator activated receptor alpha Mus musculus 4-13 19640904-4 2009 In a murine model, pretreating wild-type (WT) mice with a PPAR-alpha activator, docosahexaenoic acid (DHA), significantly reduced I/R-induced renal dysfunction (lowered serum creatinine and urea nitrogen levels), apoptotic responses (decreased apoptotic cell number and caspase-3, -8 activation), and NF-kappaB activation. Docosahexaenoic Acids 80-100 peroxisome proliferator activated receptor alpha Mus musculus 58-68 19640904-4 2009 In a murine model, pretreating wild-type (WT) mice with a PPAR-alpha activator, docosahexaenoic acid (DHA), significantly reduced I/R-induced renal dysfunction (lowered serum creatinine and urea nitrogen levels), apoptotic responses (decreased apoptotic cell number and caspase-3, -8 activation), and NF-kappaB activation. Docosahexaenoic Acids 102-105 peroxisome proliferator activated receptor alpha Mus musculus 58-68 18033239-5 2008 The PPARalpha activator docosahexaenoic acid given to gentamicin-treated mice significantly reduced the number of apoptotic cells in renal cortex, but this protective effect was not seen in PPARalpha knockout mice. Docosahexaenoic Acids 24-44 peroxisome proliferator activated receptor alpha Mus musculus 190-199 18301758-7 2008 In addition, the majority of genes regulated by unsaturated fatty acids, especially docosahexaenoic acid, were also regulated by the specific PPARalpha agonist WY14643. Docosahexaenoic Acids 84-104 peroxisome proliferator activated receptor alpha Mus musculus 142-151 33546405-7 2021 The combination of DHA + exercise potentiated an increase in Cpt1a and Ppara genes, and AMPK activation, key regulators of fatty acid oxidation. Docosahexaenoic Acids 19-22 peroxisome proliferator activated receptor alpha Mus musculus 71-76 17671096-8 2007 To confirm the protective role of PPAR-alpha in vivo, PPAR-alpha activator docosahexaenoic acid (DHA) was administered to doxorubicin-treated mice, and it has been shown to significantly reduce the doxorubicin-induced apoptotic cells in renal cortex. Docosahexaenoic Acids 75-95 peroxisome proliferator activated receptor alpha Mus musculus 34-44 17671096-8 2007 To confirm the protective role of PPAR-alpha in vivo, PPAR-alpha activator docosahexaenoic acid (DHA) was administered to doxorubicin-treated mice, and it has been shown to significantly reduce the doxorubicin-induced apoptotic cells in renal cortex. Docosahexaenoic Acids 75-95 peroxisome proliferator activated receptor alpha Mus musculus 54-64 17671096-8 2007 To confirm the protective role of PPAR-alpha in vivo, PPAR-alpha activator docosahexaenoic acid (DHA) was administered to doxorubicin-treated mice, and it has been shown to significantly reduce the doxorubicin-induced apoptotic cells in renal cortex. Docosahexaenoic Acids 97-100 peroxisome proliferator activated receptor alpha Mus musculus 34-44 17671096-8 2007 To confirm the protective role of PPAR-alpha in vivo, PPAR-alpha activator docosahexaenoic acid (DHA) was administered to doxorubicin-treated mice, and it has been shown to significantly reduce the doxorubicin-induced apoptotic cells in renal cortex. Docosahexaenoic Acids 97-100 peroxisome proliferator activated receptor alpha Mus musculus 54-64 35126352-11 2021 Furthermore, DHA"s effects were associated with downregulation of cSiO2-induced pathways involving i) inhibition of ARE-mediated mRNA decay, ii) bacterial and viral pattern recognition receptor activation, or iii) TREM1, STAT3, NF-kappaB, and VEGF signaling and with upregulation of PPAR, LXR/RXR and PPARalpha/RXRalpha signaling. Docosahexaenoic Acids 13-16 peroxisome proliferator activated receptor alpha Mus musculus 283-287 35126352-11 2021 Furthermore, DHA"s effects were associated with downregulation of cSiO2-induced pathways involving i) inhibition of ARE-mediated mRNA decay, ii) bacterial and viral pattern recognition receptor activation, or iii) TREM1, STAT3, NF-kappaB, and VEGF signaling and with upregulation of PPAR, LXR/RXR and PPARalpha/RXRalpha signaling. Docosahexaenoic Acids 13-16 peroxisome proliferator activated receptor alpha Mus musculus 301-310 17889625-9 2008 DHA pretreatment in vivo decreased TNFalpha secretion and p65 activity, and increased PPARalpha and gamma expression and function. Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor alpha Mus musculus 86-95 17889625-10 2008 The effects of DHA could be reproduced by PPAR agonists and blocked by a PPARalpha antagonist. Docosahexaenoic Acids 15-18 peroxisome proliferator activated receptor alpha Mus musculus 42-46 17889625-10 2008 The effects of DHA could be reproduced by PPAR agonists and blocked by a PPARalpha antagonist. Docosahexaenoic Acids 15-18 peroxisome proliferator activated receptor alpha Mus musculus 73-82 16540796-11 2006 DHA treatment led to 7.0-fold increase in PPARalpha mRNA levels in cftr mice (P < 0.01). Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor alpha Mus musculus 42-51 16540796-13 2006 CONCLUSION: DSS induced bile duct injury in cftr mice is associated with a defect in PPARalpha expression, which is reversed by DHA. Docosahexaenoic Acids 128-131 peroxisome proliferator activated receptor alpha Mus musculus 85-94 10522648-0 1999 The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice. Docosahexaenoic Acids 19-39 peroxisome proliferator activated receptor alpha Mus musculus 4-8 10522648-5 1999 This study was designed to determine if treatment with the PPAR activator docosahexaenoic acid (DHA) would also lower APAP toxicity. Docosahexaenoic Acids 74-94 peroxisome proliferator activated receptor alpha Mus musculus 59-63 10522648-5 1999 This study was designed to determine if treatment with the PPAR activator docosahexaenoic acid (DHA) would also lower APAP toxicity. Docosahexaenoic Acids 96-99 peroxisome proliferator activated receptor alpha Mus musculus 59-63 34653759-6 2021 In DHA-fed ApoE -/- mice, LXRalpha/beta and PPARalpha protein expression down-regulated in cytoplasm, but LXRalpha/beta protein expression up-regulated in nucleus. Docosahexaenoic Acids 3-6 peroxisome proliferator activated receptor alpha Mus musculus 44-53 32832005-13 2020 DHA seems to attenuate MI-induced cardiomyocyte injury partly by transient PPAR-alpha downregulation, diminishing the need for antioxidant mechanisms including mitochondrial function, or alpha- to beta-MHC isoform switch. Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor alpha Mus musculus 75-85 33681679-8 2021 These effects were demonstrated to be mediated by the reduced function of the peroxisome proliferator-activated receptor alpha (PPARalpha)-fibroblast growth factor 21 (FGF21) axis, which can be reversed by treatment with docosahexaenoic acid, PPARalpha agonist, or FGF21. Docosahexaenoic Acids 221-241 peroxisome proliferator activated receptor alpha Mus musculus 78-126 32832005-7 2020 Cardiac function was assessed using a pressure-volume catheter for up to 14 d. Results: DHA supplementation significantly attenuated the induction of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) (2.3 +- 0.4 CD vs. 1.4 +- 0.3 DHA) after LAD occlusion. Docosahexaenoic Acids 88-91 peroxisome proliferator activated receptor alpha Mus musculus 150-198 32832005-7 2020 Cardiac function was assessed using a pressure-volume catheter for up to 14 d. Results: DHA supplementation significantly attenuated the induction of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) (2.3 +- 0.4 CD vs. 1.4 +- 0.3 DHA) after LAD occlusion. Docosahexaenoic Acids 88-91 peroxisome proliferator activated receptor alpha Mus musculus 200-210 32832005-7 2020 Cardiac function was assessed using a pressure-volume catheter for up to 14 d. Results: DHA supplementation significantly attenuated the induction of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) (2.3 +- 0.4 CD vs. 1.4 +- 0.3 DHA) after LAD occlusion. Docosahexaenoic Acids 242-245 peroxisome proliferator activated receptor alpha Mus musculus 200-210 26690553-12 2015 Fatty acid beta-oxidation related genes, on the other hand, such as peroxisome proliferator-activated receptor alpha (PPARalpha), carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase 1 (ACOX1) were elevated in both WT and SKO groups on DHA/EPA diets. Docosahexaenoic Acids 241-244 peroxisome proliferator activated receptor alpha Mus musculus 68-116 31388404-0 2019 Deficiency or activation of peroxisome proliferator-activated receptor alpha reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice. Docosahexaenoic Acids 139-159 peroxisome proliferator activated receptor alpha Mus musculus 28-76 31388404-3 2019 Therefore, it was hypothesized that the tissue accretion of endogenously synthesized DHA could be modified by PPARalpha. Docosahexaenoic Acids 85-88 peroxisome proliferator activated receptor alpha Mus musculus 110-119 31388404-7 2019 RESULTS: PPARalpha ablation reduced the hepatic Acox, Fads1, and Fads2 mRNA levels, as well as the DHA concentration in the liver, but not in the brain cortex. Docosahexaenoic Acids 99-102 peroxisome proliferator activated receptor alpha Mus musculus 9-18 31388404-8 2019 In contrast, PPARalpha activation increased hepatic Acox, Fads1, Fads2 and Elovl5 mRNA levels, but reduced the DHA concentrations in the liver, retina, and phospholipid of brain cortex, and decreased mRNA and protein levels of the brain-derived neurotrophic factor in brain cortex. Docosahexaenoic Acids 111-114 peroxisome proliferator activated receptor alpha Mus musculus 13-22 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 22-25 peroxisome proliferator activated receptor alpha Mus musculus 36-45 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 22-25 peroxisome proliferator activated receptor alpha Mus musculus 74-83 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 22-25 peroxisome proliferator activated receptor alpha Mus musculus 190-199 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 122-125 peroxisome proliferator activated receptor alpha Mus musculus 74-83 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 122-125 peroxisome proliferator activated receptor alpha Mus musculus 190-199 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 122-125 peroxisome proliferator activated receptor alpha Mus musculus 74-83 28073164-8 2017 In addition to GNPAT, DHA activated PPARalpha and increased expression of Pparalpha and its target genes, suggesting that DHA in the DHA-containing plasmalogens contributed to activation of PPARalpha. Docosahexaenoic Acids 122-125 peroxisome proliferator activated receptor alpha Mus musculus 190-199 29859326-0 2018 A role for peroxisome proliferator-activated receptor alpha in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole. Docosahexaenoic Acids 90-110 peroxisome proliferator activated receptor alpha Mus musculus 11-59 29859326-3 2018 We investigated probable involvement of PPARalpha in the anticonvulsant effect of DHA in pentylenetetrazole (PTZ) model of clonic seizures. Docosahexaenoic Acids 82-85 peroxisome proliferator activated receptor alpha Mus musculus 40-49 29859326-14 2018 PPARalpha is involved in the anticonvulsant effect of DHA in PTZ model of clonic seizures in mice. Docosahexaenoic Acids 54-57 peroxisome proliferator activated receptor alpha Mus musculus 0-9 28940752-0 2017 Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-alpha and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation. Docosahexaenoic Acids 21-41 peroxisome proliferator activated receptor alpha Mus musculus 137-147 28872641-6 2017 Regulation of these genes was mediated by the nuclear receptor genes Rxr and Ppar, whose promoters were hyper-methylated by the deprivation of dietary AA and DHA. Docosahexaenoic Acids 158-161 peroxisome proliferator activated receptor alpha Mus musculus 77-81 28356106-6 2017 The DHA/EPA 1:2 group showed lower serum triglycerides (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol levels, lower SREBP-1C, FAS, and ACC-1 relative mRNA expression, and higher Fra1 mRNA expression, with higher relative mRNA expression of enzymes such as AMPK, PPARalpha, and HSL observed in the DHA/EPA 1:1 group. Docosahexaenoic Acids 4-7 peroxisome proliferator activated receptor alpha Mus musculus 285-294 26690553-12 2015 Fatty acid beta-oxidation related genes, on the other hand, such as peroxisome proliferator-activated receptor alpha (PPARalpha), carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase 1 (ACOX1) were elevated in both WT and SKO groups on DHA/EPA diets. Docosahexaenoic Acids 241-244 peroxisome proliferator activated receptor alpha Mus musculus 118-127 24133194-0 2013 DHA attenuates postprandial hyperlipidemia via activating PPARalpha in intestinal epithelial cells. Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor alpha Mus musculus 58-67 24133194-2 2013 Docosahexaenoic acid (DHA) could improve postprandial hyperlipidemia, however, its relationship with intestinal PPARalpha activation is not revealed. Docosahexaenoic Acids 0-20 peroxisome proliferator activated receptor alpha Mus musculus 112-121 24133194-7 2013 Furthermore, the effects of DHA on intestinal lipid secretion and postprandial hyperlipidemia were abolished in PPARalpha knockout mice. Docosahexaenoic Acids 28-31 peroxisome proliferator activated receptor alpha Mus musculus 112-121 24133194-8 2013 In conclusion, the present work suggests that DHA can inhibit the secretion of TG from intestinal epithelial cells via PPARalpha activation, which attenuates postprandial hyperlipidemia. Docosahexaenoic Acids 46-49 peroxisome proliferator activated receptor alpha Mus musculus 119-128