PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31087413-9 2019 Earlier studies have shown that DHA is a natural ligand for PPARgamma, thus being a potential alternative to the antidiabetic thiazolidinediones. Docosahexaenoic Acids 32-35 peroxisome proliferator activated receptor gamma Mus musculus 60-69 34785255-0 2022 Docosahexaenoic acid reduces hypoglycemia-induced neuronal necroptosis via the peroxisome proliferator-activated receptor gamma / nuclear factor-kappaB pathway. Docosahexaenoic Acids 0-20 peroxisome proliferator activated receptor gamma Mus musculus 79-127 27647308-0 2016 A Novel Combination of Docosahexaenoic Acid, All-Trans Retinoic Acid, and 1, 25-Dihydroxyvitamin D3 Reduces T-Bet Gene Expression, Serum Interferon Gamma, and Clinical Scores but Promotes PPARgamma Gene Expression in Experimental Autoimmune Encephalomyelitis. Docosahexaenoic Acids 23-43 peroxisome proliferator activated receptor gamma Mus musculus 188-197 26954392-10 2016 We determined whether GW9662, a specific PPARgamma inhibitor, could abolish the anti-inflammatory effect of DHA and celecoxib. Docosahexaenoic Acids 108-111 peroxisome proliferator activated receptor gamma Mus musculus 41-50 23199346-2 2012 In fact, DHA can down-regulate lipolysaccharide (LPS)-induced activation of NF-kappaB via a PPARgamma-dependent pathway. Docosahexaenoic Acids 9-12 peroxisome proliferator activated receptor gamma Mus musculus 92-101 21929559-3 2012 We now report that docosahexaenoic acid (DHA), a 22:6 PUFA, affects alpha-Syn oligomerization by activating retinoic X receptor (RXR) and peroxisome proliferator-activated receptor gamma2 (PPARgamma2). Docosahexaenoic Acids 19-39 peroxisome proliferator activated receptor gamma Mus musculus 189-199 21929559-3 2012 We now report that docosahexaenoic acid (DHA), a 22:6 PUFA, affects alpha-Syn oligomerization by activating retinoic X receptor (RXR) and peroxisome proliferator-activated receptor gamma2 (PPARgamma2). Docosahexaenoic Acids 41-44 peroxisome proliferator activated receptor gamma Mus musculus 138-187 21929559-3 2012 We now report that docosahexaenoic acid (DHA), a 22:6 PUFA, affects alpha-Syn oligomerization by activating retinoic X receptor (RXR) and peroxisome proliferator-activated receptor gamma2 (PPARgamma2). Docosahexaenoic Acids 41-44 peroxisome proliferator activated receptor gamma Mus musculus 189-199 21569430-13 2011 DHA, beta-carotene and hydroxytyrosol inhibited the gene expression of PPARgamma, C/EBPalpha, aP2 and CPT-1beta. Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor gamma Mus musculus 71-80 18191038-1 2008 (5E,7Z,10Z,13Z,16Z,19Z)-4-Hydroxy-5,7,10,13,16,19-docosahexaenoic acid (4-OHDHA) is a potential agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) and antidiabetic agent as has been previously reported. Docosahexaenoic Acids 50-70 peroxisome proliferator activated receptor gamma Mus musculus 107-155 18191038-1 2008 (5E,7Z,10Z,13Z,16Z,19Z)-4-Hydroxy-5,7,10,13,16,19-docosahexaenoic acid (4-OHDHA) is a potential agonist of peroxisome proliferator-activated receptor-gamma (PPARgamma) and antidiabetic agent as has been previously reported. Docosahexaenoic Acids 50-70 peroxisome proliferator activated receptor gamma Mus musculus 157-166 27647308-9 2016 These findings highlighted that ATRA, D3, and DHA combination modulated PPARgamma and T-bet gene expression and resulted in decrease in Th1 response and lymphocyte invasion into the central nervous system (CNS) and resultant inflammation. Docosahexaenoic Acids 46-49 peroxisome proliferator activated receptor gamma Mus musculus 72-81 25445227-0 2015 Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor gamma activation. Docosahexaenoic Acids 0-20 peroxisome proliferator activated receptor gamma Mus musculus 64-112 25445227-6 2015 To demonstrate the involvement of peroxisome proliferator-activated receptor gamma (PPARgamma) in DHA-mediated effects, siRNA against PPARgamma was utilized. Docosahexaenoic Acids 98-101 peroxisome proliferator activated receptor gamma Mus musculus 34-82 25445227-6 2015 To demonstrate the involvement of peroxisome proliferator-activated receptor gamma (PPARgamma) in DHA-mediated effects, siRNA against PPARgamma was utilized. Docosahexaenoic Acids 98-101 peroxisome proliferator activated receptor gamma Mus musculus 84-93 25445227-6 2015 To demonstrate the involvement of peroxisome proliferator-activated receptor gamma (PPARgamma) in DHA-mediated effects, siRNA against PPARgamma was utilized. Docosahexaenoic Acids 98-101 peroxisome proliferator activated receptor gamma Mus musculus 134-143 25445227-10 2015 Notably, knockdown of PPARgamma abolished the stimulatory effect of DHA on M2 polarization as well as efferocytosis. Docosahexaenoic Acids 68-71 peroxisome proliferator activated receptor gamma Mus musculus 22-31 25044948-8 2014 Pretreatment with PPARgamma inhibitor (GW9662) abolished the inhibitory effect of DHA (100 muM) on LA-induced IkappaB degradation, p65 translocation, and MCP-1 expression in ARPE-19 cells (p < 0.05), as well as tube formation in RF6A. Docosahexaenoic Acids 82-85 peroxisome proliferator activated receptor gamma Mus musculus 18-27 23619236-1 2013 Activation of the transcription factor PPARgamma by the n-3 fatty acid docosahexaenoic acid (DHA) is implicated in controlling proinflammatory cytokine secretion, but the intracellular signaling pathways engaged by PPARgamma are incompletely characterized. Docosahexaenoic Acids 71-91 peroxisome proliferator activated receptor gamma Mus musculus 39-48 23619236-1 2013 Activation of the transcription factor PPARgamma by the n-3 fatty acid docosahexaenoic acid (DHA) is implicated in controlling proinflammatory cytokine secretion, but the intracellular signaling pathways engaged by PPARgamma are incompletely characterized. Docosahexaenoic Acids 93-96 peroxisome proliferator activated receptor gamma Mus musculus 39-48 23619236-1 2013 Activation of the transcription factor PPARgamma by the n-3 fatty acid docosahexaenoic acid (DHA) is implicated in controlling proinflammatory cytokine secretion, but the intracellular signaling pathways engaged by PPARgamma are incompletely characterized. Docosahexaenoic Acids 93-96 peroxisome proliferator activated receptor gamma Mus musculus 215-224 23619236-4 2013 Accordingly, TH17 cells induced in vitro displayed increased SOCS3 expression and diminished capacity to produce interleukin (IL)-17 following activation of PPARgamma by DHA. Docosahexaenoic Acids 170-173 peroxisome proliferator activated receptor gamma Mus musculus 157-166 21929559-3 2012 We now report that docosahexaenoic acid (DHA), a 22:6 PUFA, affects alpha-Syn oligomerization by activating retinoic X receptor (RXR) and peroxisome proliferator-activated receptor gamma2 (PPARgamma2). Docosahexaenoic Acids 19-39 peroxisome proliferator activated receptor gamma Mus musculus 138-187 20970313-4 2011 The current experiment was designed to determine the potential for PUFA, particularly eicosapentaenoic acid and docosahexaenoic acid, to activate the function of porcine PPARgamma in vivo. Docosahexaenoic Acids 112-132 peroxisome proliferator activated receptor gamma Mus musculus 170-179 20383747-5 2011 Data showed that, DHA up-regulated PPARgamma, HSL and TGH in adipose tissue, but it had no effect on SREBP-1c and FAS expression. Docosahexaenoic Acids 18-21 peroxisome proliferator activated receptor gamma Mus musculus 35-44 20122166-11 2010 DHA inhibition of IL-12 expression was mediated through activation of PPARgamma and inhibition of NFkappaBp65 nuclear translocation. Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor gamma Mus musculus 70-79 20122166-15 2010 The effect of DHA on IL-12 expression was mediated through activation of PPARgamma and inhibition of NFkappaB. Docosahexaenoic Acids 14-17 peroxisome proliferator activated receptor gamma Mus musculus 73-82 33476356-5 2021 1%DHA and 1%EPA inhibit adipogenesis by down-regulating GPR120; 4%DHA stimulates browning of WAT and improves IR and inflammatory infiltration by up-regulating PPARgamma; 4%EPA exerts its anti-obesity effect by mechanisms independent of PPARgamma and GPR120 signaling. Docosahexaenoic Acids 66-69 peroxisome proliferator activated receptor gamma Mus musculus 160-169 35189618-9 2022 In an ex vivo adipocyte culture study, DHA dose-dependently suppressed the lipopolysaccharide-induced inflammation in the adipocyte tissue of WT mice, which was reversed by pretreatment with AH7614, a GPR120/FFAR4 antagonist, but not GPR40 or peroxisome proliferator-activated receptor gamma antagonist. Docosahexaenoic Acids 39-42 peroxisome proliferator activated receptor gamma Mus musculus 243-291 31955908-3 2020 The study aimed to evaluate the effects of EPA and DHA on adipogenesis, especially in the PPARgamma (peroxisome proliferator-activated receptor-gamma) and Cidec (cell death-inducing DFFA-like effector c) pathway. Docosahexaenoic Acids 51-54 peroxisome proliferator activated receptor gamma Mus musculus 90-99 31955908-8 2020 EPA and DHA had a significant impact on the expression of cleaved CASPASE 3, which increases cell apoptosis and gene expressions of Ppargamma and Cidec in the treated groups. Docosahexaenoic Acids 8-11 peroxisome proliferator activated receptor gamma Mus musculus 132-141 31955908-10 2020 In conclusion, the study determined the ability of both EPA and DHA, alone or combined, in the adipogenesis modulation in cultured 3T3-L1 adipocytes, affecting the cell differentiation, maturation, and consequently, reducing adipogenesis via PPARgamma-CIDEC suppression. Docosahexaenoic Acids 64-67 peroxisome proliferator activated receptor gamma Mus musculus 242-251 31802926-0 2019 Effects Of PPARgamma2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA. Docosahexaenoic Acids 75-78 peroxisome proliferator activated receptor gamma Mus musculus 11-21 31802926-8 2019 Results: PPARgamma2 Pro12Ala variant reduced lipid droplet accumulation in 3T3-L1 preadipocytes treated with or without 50 mumol/L DHA, but not with 200 mumol/L DHA, compared to that of wild-type PPARgamma2. Docosahexaenoic Acids 131-134 peroxisome proliferator activated receptor gamma Mus musculus 9-19 31802926-8 2019 Results: PPARgamma2 Pro12Ala variant reduced lipid droplet accumulation in 3T3-L1 preadipocytes treated with or without 50 mumol/L DHA, but not with 200 mumol/L DHA, compared to that of wild-type PPARgamma2. Docosahexaenoic Acids 131-134 peroxisome proliferator activated receptor gamma Mus musculus 196-206 31802926-10 2019 However, the absence of DHA blocked PPARgamma2 Ala12 variant-induced effects on adiponectin production. Docosahexaenoic Acids 24-27 peroxisome proliferator activated receptor gamma Mus musculus 36-46 31802926-12 2019 Conclusion: These results indicated that the effects of PPARgamma2 Pro12Ala variant were dependent on DHA concentration. Docosahexaenoic Acids 102-105 peroxisome proliferator activated receptor gamma Mus musculus 56-66 31437794-0 2019 Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARgamma-dependent manner. Docosahexaenoic Acids 0-20 peroxisome proliferator activated receptor gamma Mus musculus 96-105 31437794-2 2019 In this study, we investigated the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in DHA regulation of liver fibrosis. Docosahexaenoic Acids 107-110 peroxisome proliferator activated receptor gamma Mus musculus 43-91 31437794-2 2019 In this study, we investigated the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in DHA regulation of liver fibrosis. Docosahexaenoic Acids 107-110 peroxisome proliferator activated receptor gamma Mus musculus 93-102 31437794-5 2019 Antagonism of PPARgamma by GW9662 abrogated the effects of DHA on HSCs. Docosahexaenoic Acids 59-62 peroxisome proliferator activated receptor gamma Mus musculus 14-23 31437794-6 2019 Computer-aided molecular docking predicted that DHA bound to PPARgamma via hydrogen bonding with residues Ser289, His323, Tyr473, and His499. Docosahexaenoic Acids 48-51 peroxisome proliferator activated receptor gamma Mus musculus 61-70 31437794-7 2019 We overexpressed Ser289 mutant PPARgamma in HSC-LX2 cells and investigated fibrotic marker modulation, and found that DHA effects on HSCs were diminished. Docosahexaenoic Acids 118-121 peroxisome proliferator activated receptor gamma Mus musculus 31-40 31437794-8 2019 Thus, bonding with the Ser289 residue might be indispensable for DHA to activate PPARgamma to exert its inhibiting effect on activated HSCs. Docosahexaenoic Acids 65-68 peroxisome proliferator activated receptor gamma Mus musculus 81-90 31437794-9 2019 Last, data from a CCl4-treated mouse model confirmed that PPARgamma activation was required for DHA to attenuate liver fibrosis. Docosahexaenoic Acids 96-99 peroxisome proliferator activated receptor gamma Mus musculus 58-67 31616405-12 2019 DHA"s suppressive effects were linked to inhibition of LPS-induced Nlrp3, Il1b, and Il1a transcription, potentially through the activation of PPARgamma. Docosahexaenoic Acids 0-3 peroxisome proliferator activated receptor gamma Mus musculus 142-151