PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30706921-0 2019 DHA and vitamin E antagonized the Abeta25-35-mediated neuron oxidative damage through activation of Nrf2 signaling pathways and regulation of CD36, SRB1 and FABP5 expression in PC12 cells. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 30706921-7 2019 Activation of the Nrf2 signaling pathway and regulation of CD36, SRB1 and FABP5 expression were observed in DHA- and DHA + VE-pretreated cells. Docosahexaenoic Acids 108-111 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-22 30706921-7 2019 Activation of the Nrf2 signaling pathway and regulation of CD36, SRB1 and FABP5 expression were observed in DHA- and DHA + VE-pretreated cells. Docosahexaenoic Acids 117-120 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-22 24139673-8 2013 In parallel with these immunosuppressive phenomena, DHA attenuated post-stroke oxidative stress, c-Jun N-terminal kinase (JNK) phosphorylation, c-Jun phosphorylation and activating protein-1 (AP-1) activation but further elevated ischemia-induced NF-E2-related factor-2 (Nrf2) and heme oxygenase-1 (HO-1) expression. Docosahexaenoic Acids 52-55 NFE2 like bZIP transcription factor 2 Rattus norvegicus 247-269 29663102-0 2018 Docosahexaenoic Acid (DHA) Provides Neuroprotection in Traumatic Brain Injury Models via Activating Nrf2-ARE Signaling. Docosahexaenoic Acids 0-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 29663102-0 2018 Docosahexaenoic Acid (DHA) Provides Neuroprotection in Traumatic Brain Injury Models via Activating Nrf2-ARE Signaling. Docosahexaenoic Acids 22-25 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 29663102-5 2018 Relationships between nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway-related genes and DHA were explored by RT-PCR and Western blot. Docosahexaenoic Acids 132-135 NFE2 like bZIP transcription factor 2 Rattus norvegicus 22-65 29663102-5 2018 Relationships between nuclear factor erythroid 2-related factor 2-antioxidant response element (Nrf2-ARE) pathway-related genes and DHA were explored by RT-PCR and Western blot. Docosahexaenoic Acids 132-135 NFE2 like bZIP transcription factor 2 Rattus norvegicus 96-100 29663102-9 2018 Moreover, immunofluorescence and Western blot experiments revealed that DHA facilitated the translocation of Nrf2 to the nucleus. Docosahexaenoic Acids 72-75 NFE2 like bZIP transcription factor 2 Rattus norvegicus 109-113 29663102-11 2018 DHA exerted neuroprotective influence on the TBI models, potentially through activating the Nrf2- ARE pathway. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 92-96 24140970-5 2013 We found that DHA-enriched cells exacerbate ROS generation, decrease cell viability and increase Nrf2 nuclear translocation and HO-1 expression. Docosahexaenoic Acids 14-17 NFE2 like bZIP transcription factor 2 Rattus norvegicus 97-101 28751206-9 2017 Additionally, significant increases in SOD activity and Nrf2 expression were observed after DHA injection; GFAP and NF-kappaB expression levels were markedly decreased by DHA injection. Docosahexaenoic Acids 92-95 NFE2 like bZIP transcription factor 2 Rattus norvegicus 56-60 24139673-8 2013 In parallel with these immunosuppressive phenomena, DHA attenuated post-stroke oxidative stress, c-Jun N-terminal kinase (JNK) phosphorylation, c-Jun phosphorylation and activating protein-1 (AP-1) activation but further elevated ischemia-induced NF-E2-related factor-2 (Nrf2) and heme oxygenase-1 (HO-1) expression. Docosahexaenoic Acids 52-55 NFE2 like bZIP transcription factor 2 Rattus norvegicus 271-275 24139673-9 2013 DHA treatment also had an immunosuppressive effect in lipopolysaccharide/interferon-gamma-stimulated glial cultures by attenuating JNK phosphorylation, c-Jun phosphorylation and AP-1 activation and augmenting Nrf2 and HO-1 expression. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 209-213 24139673-10 2013 In summary, we have shown that DHA exhibited neuroprotective and anti-inflammatory effects against ischemic brain injury and these effects were accompanied by decreased oxidative stress and JNK/AP-1 signaling as well as enhanced Nrf2/HO-1 expression. Docosahexaenoic Acids 31-34 NFE2 like bZIP transcription factor 2 Rattus norvegicus 229-233 23232054-0 2012 A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats. Docosahexaenoic Acids 83-103 NFE2 like bZIP transcription factor 2 Rattus norvegicus 149-153 33279658-7 2021 DHA supplementation also induced mRNA expression of antioxidant genes, such as sod1 and catalase, and Nrf2 protein expression in the striatum. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 102-106 34466073-11 2021 DHA may alleviate the impairment of spleen cellular immunity in IUGR rat pups by inhibiting oxidative stress and apoptosis related to the activation of Nrf2 signaling pathway. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 152-156 34934425-13 2022 Furthermore, the protein expression levels of Nrf2 and HO-1 were demonstrated to be significantly increased in rats treated with DHA and exposed to repeated sevoflurane anesthesia compared with those in untreated rats that underwent repeated sevoflurane anesthesia. Docosahexaenoic Acids 129-132 NFE2 like bZIP transcription factor 2 Rattus norvegicus 46-50 34934425-14 2022 In conclusion, the present study revealed that DHA exerted protective effects against impairments in learning and memory induced by repeated sevoflurane anesthesia in aged rats, which may be associated with the Nrf2/HO-1 signaling pathway. Docosahexaenoic Acids 47-50 NFE2 like bZIP transcription factor 2 Rattus norvegicus 211-215 34466073-0 2021 Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups. Docosahexaenoic Acids 0-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 35-39 34466073-10 2021 (4) DHA increased protein expression of the Nrf2 signaling pathway and the downstream antioxidant genes GSH-PX and CAT. Docosahexaenoic Acids 4-7 NFE2 like bZIP transcription factor 2 Rattus norvegicus 44-48 33158207-0 2020 Docosahexaenoic Acid Induces Expression of NAD(P)H: Quinone Oxidoreductase and Heme Oxygenase-1 through Activation of Nrf2 in Cerulein-Stimulated Pancreatic Acinar Cells. Docosahexaenoic Acids 0-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 118-122 33158207-9 2020 Our results showed that DHA upregulates the expression of NQO1 and HO-1 in cerulein-stimulated AR42J cells by promoting phosphorylation and nuclear translocation of Nrf2. Docosahexaenoic Acids 24-27 NFE2 like bZIP transcription factor 2 Rattus norvegicus 165-169 33158207-10 2020 DHA increased interaction between Keap1 and Nrf2 in AR42J cells, which may increase Nrf2 activity by inhibiting Keap1-mediated sequestration of Nrf2. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 44-48 33158207-10 2020 DHA increased interaction between Keap1 and Nrf2 in AR42J cells, which may increase Nrf2 activity by inhibiting Keap1-mediated sequestration of Nrf2. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 84-88 33158207-10 2020 DHA increased interaction between Keap1 and Nrf2 in AR42J cells, which may increase Nrf2 activity by inhibiting Keap1-mediated sequestration of Nrf2. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 84-88 33158207-12 2020 In conclusion, DHA inhibits ROS-mediated IL-6 expression by upregulating Nrf2-mediated expression of NQO1 and HO-1 in cerulein-stimulated pancreatic acinar cells. Docosahexaenoic Acids 15-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 73-77 33158207-13 2020 DHA may exert positive modulatory effects on acute pancreatitis by inhibiting oxidative stress and inflammatory cytokine production by activating Nrf2 signaling in pancreatic acinar cells. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 146-150 33158207-7 2020 In this study, we investigated whether DHA reduces ROS levels and inhibits IL-6 expression via Nrf2 signaling in pancreatic acinar (AR42J) cells stimulated with cerulein, as an in vitro model of acute pancreatitis. Docosahexaenoic Acids 39-42 NFE2 like bZIP transcription factor 2 Rattus norvegicus 95-99 30578580-5 2019 Combined DHA + T3 protocol led to increased liver AMPK, PGC-1alpha, NRF-2, COX-IV, and beta-ATP synthase mRNAs, with concomitant higher protein levels of COX-IV and NRF-2, 369% enhancement in the NAD+ /NADH ratio, 47% decrease in histone 3 acetylation and 162% increase in serum levels of beta-hydroxybutyrate over control values. Docosahexaenoic Acids 9-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 68-73 32676950-0 2020 Docosahexaenoic Acid Protects Traumatic Brain Injury by Regulating NOX2 Generation via Nrf2 Signaling Pathway. Docosahexaenoic Acids 0-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 87-91 31017264-0 2019 DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 101-107 31017264-8 2019 These findings provide evidence suggesting that DHA is able to prevent H2O2-induced oxidative damage to PC12 cells, which is attributed to its antioxidant and anti-apoptotic effects via the regulation NFE2L2/HO-1 signaling. Docosahexaenoic Acids 48-51 NFE2 like bZIP transcription factor 2 Rattus norvegicus 201-207 32676950-1 2020 Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX2 in this effect has not been illuminated. Docosahexaenoic Acids 0-20 NFE2 like bZIP transcription factor 2 Rattus norvegicus 122-126 32676950-1 2020 Docosahexaenoic acid (DHA) is verified to have neuroprotective effects on traumatic brain injury (TBI) rats by activating Nrf2 signaling pathway, but the role of NOX2 in this effect has not been illuminated. Docosahexaenoic Acids 22-25 NFE2 like bZIP transcription factor 2 Rattus norvegicus 122-126 32676950-8 2020 DHA promoted the nuclear transposition of Nrf2 and the expression levels of HO-1 and NQO-1 in hippocampal CA1 region and hippocampal neurons. Docosahexaenoic Acids 0-3 NFE2 like bZIP transcription factor 2 Rattus norvegicus 42-46 32676950-10 2020 Both in vivo and in vitro experiments demonstrated that DHA treated TBI by reducing NOX2 generation that might function on Nrf2 signaling pathway, providing a potential evidence for its clinical application. Docosahexaenoic Acids 56-59 NFE2 like bZIP transcription factor 2 Rattus norvegicus 123-127 30578580-5 2019 Combined DHA + T3 protocol led to increased liver AMPK, PGC-1alpha, NRF-2, COX-IV, and beta-ATP synthase mRNAs, with concomitant higher protein levels of COX-IV and NRF-2, 369% enhancement in the NAD+ /NADH ratio, 47% decrease in histone 3 acetylation and 162% increase in serum levels of beta-hydroxybutyrate over control values. Docosahexaenoic Acids 9-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 165-170