PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26860701-1 2016 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a halogenated aromatic hydrocarbon that elicits toxicity through the aryl hydrocarbon receptor (AhR). Hydrocarbons, Aromatic 60-80 aryl hydrocarbon receptor Homo sapiens 115-140 28351761-1 2017 Exposure to environmental aryl hydrocarbon receptor (AhR) agonists, such as halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), has great impacts on the development of various lung diseases. Hydrocarbons, Aromatic 88-109 aryl hydrocarbon receptor Homo sapiens 26-51 28351761-1 2017 Exposure to environmental aryl hydrocarbon receptor (AhR) agonists, such as halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), has great impacts on the development of various lung diseases. Hydrocarbons, Aromatic 88-109 aryl hydrocarbon receptor Homo sapiens 53-56 26860701-1 2016 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a halogenated aromatic hydrocarbon that elicits toxicity through the aryl hydrocarbon receptor (AhR). Hydrocarbons, Aromatic 60-80 aryl hydrocarbon receptor Homo sapiens 142-145 26160521-6 2015 However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP. Hydrocarbons, Aromatic 25-45 aryl hydrocarbon receptor Homo sapiens 62-65 23512538-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemical pollutants, including polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hydrocarbons, Aromatic 230-251 aryl hydrocarbon receptor Homo sapiens 4-29 24498387-1 2014 The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes. Hydrocarbons, Aromatic 101-122 aryl hydrocarbon receptor Homo sapiens 4-29 24498387-1 2014 The aryl hydrocarbon receptor (AHR) binds to environmental toxicants including synthetic halogenated aromatic hydrocarbons and is involved in a diverse array of biological processes. Hydrocarbons, Aromatic 101-122 aryl hydrocarbon receptor Homo sapiens 31-34 25265996-4 2015 TCDD and related polyhalogenated aromatic hydrocarbons are widespread industrial pollutants that activate the aryl hydrocarbon receptor (AHR). Hydrocarbons, Aromatic 33-54 aryl hydrocarbon receptor Homo sapiens 110-135 25265996-4 2015 TCDD and related polyhalogenated aromatic hydrocarbons are widespread industrial pollutants that activate the aryl hydrocarbon receptor (AHR). Hydrocarbons, Aromatic 33-54 aryl hydrocarbon receptor Homo sapiens 137-140 23512538-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemical pollutants, including polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hydrocarbons, Aromatic 230-251 aryl hydrocarbon receptor Homo sapiens 31-34 22581694-1 2012 It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Hydrocarbons, Aromatic 101-122 aryl hydrocarbon receptor Homo sapiens 26-51 22581694-1 2012 It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Hydrocarbons, Aromatic 101-122 aryl hydrocarbon receptor Homo sapiens 53-56 18203687-2 2008 The best-studied ligands for the AhR include polycyclic and halogenated aromatic hydrocarbons, the most potent of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hydrocarbons, Aromatic 72-93 aryl hydrocarbon receptor Homo sapiens 33-36 18440119-1 2008 Aromatic hydrocarbons elicit toxic and adaptive responses via the aryl hydrocarbon receptor (AHR). Hydrocarbons, Aromatic 0-21 aryl hydrocarbon receptor Homo sapiens 66-91 18440119-1 2008 Aromatic hydrocarbons elicit toxic and adaptive responses via the aryl hydrocarbon receptor (AHR). Hydrocarbons, Aromatic 0-21 aryl hydrocarbon receptor Homo sapiens 93-96 18294709-2 2008 AhR has been studied largely because of its role in toxicology-gene expression via AhR is induced by many aromatic hydrocarbons in mammals. Hydrocarbons, Aromatic 106-127 aryl hydrocarbon receptor Homo sapiens 0-3 18294709-2 2008 AhR has been studied largely because of its role in toxicology-gene expression via AhR is induced by many aromatic hydrocarbons in mammals. Hydrocarbons, Aromatic 106-127 aryl hydrocarbon receptor Homo sapiens 83-86 22476776-1 2012 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that is bound and activated by many toxic ubiquitous environmental contaminants, including the halogenated aromatic hydrocarbon, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hydrocarbons, Aromatic 186-206 aryl hydrocarbon receptor Homo sapiens 4-29 22476776-1 2012 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that is bound and activated by many toxic ubiquitous environmental contaminants, including the halogenated aromatic hydrocarbon, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hydrocarbons, Aromatic 186-206 aryl hydrocarbon receptor Homo sapiens 31-34 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Hydrocarbons, Aromatic 76-97 aryl hydrocarbon receptor Homo sapiens 0-25 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Hydrocarbons, Aromatic 76-97 aryl hydrocarbon receptor Homo sapiens 27-30 20634293-2 2010 Whereas the best-characterized high-affinity ligands include structurally related halogenated aromatic hydrocarbons (HAHs) and polycyclic aromatic hydrocarbons (PAHs), the AhR is promiscuous and can also be activated by structurally diverse exogenous and endogenous chemicals. Hydrocarbons, Aromatic 94-115 aryl hydrocarbon receptor Homo sapiens 172-175 19690180-0 2009 Aryl hydrocarbon receptor expression is associated with a family history of upper gastrointestinal tract cancer in a high-risk population exposed to aromatic hydrocarbons. Hydrocarbons, Aromatic 149-170 aryl hydrocarbon receptor Homo sapiens 0-25 18950284-1 2008 BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation. Hydrocarbons, Aromatic 24-45 aryl hydrocarbon receptor Homo sapiens 135-160 18950284-1 2008 BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation. Hydrocarbons, Aromatic 24-45 aryl hydrocarbon receptor Homo sapiens 162-165 18648615-1 2006 TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) have been classically considered as non-genotoxic compounds because they fail to be directly mutagenic in either bacteria or most in vitro assay systems. Hydrocarbons, Aromatic 31-51 aryl hydrocarbon receptor Homo sapiens 67-92 18048071-2 2008 In this study, we investigated structure-dependent differences in activation of the AhR by a series of halogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 115-136 aryl hydrocarbon receptor Homo sapiens 84-87 16601081-2 2006 Structural similarities of PBDEs with other polyhalogenated aromatic hydrocarbons that show affinity for the aryl hydrocarbon receptor (AhR), such as some polychlorinated biphenyls, raised concerns about their possible dioxin-like properties. Hydrocarbons, Aromatic 60-81 aryl hydrocarbon receptor Homo sapiens 109-134 16601081-2 2006 Structural similarities of PBDEs with other polyhalogenated aromatic hydrocarbons that show affinity for the aryl hydrocarbon receptor (AhR), such as some polychlorinated biphenyls, raised concerns about their possible dioxin-like properties. Hydrocarbons, Aromatic 60-81 aryl hydrocarbon receptor Homo sapiens 136-139 17968679-1 2007 Endothelial cells are a target of halogenated aromatic hydrocarbon toxicity following aryl hydrocarbon receptor (AHR) activation. Hydrocarbons, Aromatic 46-66 aryl hydrocarbon receptor Homo sapiens 86-111 17968679-1 2007 Endothelial cells are a target of halogenated aromatic hydrocarbon toxicity following aryl hydrocarbon receptor (AHR) activation. Hydrocarbons, Aromatic 46-66 aryl hydrocarbon receptor Homo sapiens 113-116 16902966-7 2006 We suggest that AHR diversity in vertebrates arose through both gene and whole-genome duplications combined with lineage-specific gene loss, and that sensitivity to the developmental toxicity of planar aromatic hydrocarbons may have had its origin in the evolution of the ligand-binding capacity of the AHR in the chordate lineage. Hydrocarbons, Aromatic 202-223 aryl hydrocarbon receptor Homo sapiens 16-19 16902966-7 2006 We suggest that AHR diversity in vertebrates arose through both gene and whole-genome duplications combined with lineage-specific gene loss, and that sensitivity to the developmental toxicity of planar aromatic hydrocarbons may have had its origin in the evolution of the ligand-binding capacity of the AHR in the chordate lineage. Hydrocarbons, Aromatic 202-223 aryl hydrocarbon receptor Homo sapiens 303-306 18648615-1 2006 TCDD and other polyhalogenated aromatic hydrocarbon ligands of the aryl hydrocarbon receptor (AHR) have been classically considered as non-genotoxic compounds because they fail to be directly mutagenic in either bacteria or most in vitro assay systems. Hydrocarbons, Aromatic 31-51 aryl hydrocarbon receptor Homo sapiens 94-97 14594946-1 2004 Cytochrome P-450 1A1 (CYP1A1) is known to be induced by aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), through activation of the aryl hydrocarbon receptor (AhR). Hydrocarbons, Aromatic 56-77 aryl hydrocarbon receptor Homo sapiens 157-182 15961252-5 2005 Furthermore, AhR (polycyclic aromatic hydrocarbon receptor), when activated by the binding of aromatic hydrocarbons (Ah) forms a complex with the aryl hydrocarbon nuclear-translocator chaperone protein (Arnt). Hydrocarbons, Aromatic 94-115 aryl hydrocarbon receptor Homo sapiens 13-16 16431846-2 2006 Endocrine-disrupting polyhalogenated aromatic hydrocarbons (PHAH) are environmental toxins that act in part through the ligand-activated transcription factor arylhydrocarbon receptor (AhR; dioxin receptor), and exposure to PHAH has been shown to decrease fertility. Hydrocarbons, Aromatic 37-58 aryl hydrocarbon receptor Homo sapiens 184-187 15099767-1 2004 Halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), produce a wide variety of biological and toxic effects mainly through the aryl hydrocarbon receptor (AhR)-dependent mechanism. Hydrocarbons, Aromatic 12-33 aryl hydrocarbon receptor Homo sapiens 168-193 15099767-1 2004 Halogenated aromatic hydrocarbons (HAHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), produce a wide variety of biological and toxic effects mainly through the aryl hydrocarbon receptor (AhR)-dependent mechanism. Hydrocarbons, Aromatic 12-33 aryl hydrocarbon receptor Homo sapiens 195-198 15077014-1 2004 The aryl hydrocarbon receptor (AHR) gene encodes a ligand-activated transcription factor through which planar halogenated aromatic hydrocarbons (HAHs) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as well as polynuclear aromatic hydrocarbons (PAHs) cause altered gene expression and toxicity. Hydrocarbons, Aromatic 122-143 aryl hydrocarbon receptor Homo sapiens 31-34 14594946-1 2004 Cytochrome P-450 1A1 (CYP1A1) is known to be induced by aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), through activation of the aryl hydrocarbon receptor (AhR). Hydrocarbons, Aromatic 56-77 aryl hydrocarbon receptor Homo sapiens 184-187 12505299-1 2002 The dioxin (Aryl hydrocarbon) receptor (DR) is a unique bHLH transcription factor which is activated by binding of planar aromatic hydrocarbons typified by dioxin (TCDD). Hydrocarbons, Aromatic 122-143 aryl hydrocarbon receptor Homo sapiens 12-38 14678789-1 2004 The aryl hydrocarbon receptor (AhR) mediates biological and toxicological actions of e.g., halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hydrocarbons, Aromatic 103-124 aryl hydrocarbon receptor Homo sapiens 4-29 14678789-1 2004 The aryl hydrocarbon receptor (AhR) mediates biological and toxicological actions of e.g., halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hydrocarbons, Aromatic 103-124 aryl hydrocarbon receptor Homo sapiens 31-34 12409613-1 2002 The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hydrocarbons, Aromatic 160-180 aryl hydrocarbon receptor Homo sapiens 4-29 12409613-1 2002 The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Hydrocarbons, Aromatic 160-180 aryl hydrocarbon receptor Homo sapiens 31-34 10605936-4 2000 Oxidative stress activates genes via the electrophile response element (EPRE) DNA motif, whereas dioxin (acutely) activates genes via the AHR-mediated aromatic hydrocarbon response element (AHRE) DNA motif. Hydrocarbons, Aromatic 151-171 aryl hydrocarbon receptor Homo sapiens 138-141 10788565-4 2000 Known AhR agonists (halogenated and nonhalogenated aromatic hydrocarbons) were positive in both assays, whereas the AhR antagonist alpha-naphthoflavone exhibited agonist activity only in the GRAB assay. Hydrocarbons, Aromatic 51-72 aryl hydrocarbon receptor Homo sapiens 6-9 12213569-0 2002 Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Hydrocarbons, Aromatic 59-80 aryl hydrocarbon receptor Homo sapiens 108-133 12213569-0 2002 Activation of mitogen-activated protein kinases (MAPKs) by aromatic hydrocarbons: role in the regulation of aryl hydrocarbon receptor (AHR) function. Hydrocarbons, Aromatic 59-80 aryl hydrocarbon receptor Homo sapiens 135-138 12002481-1 2002 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototype of environmental halogenated aromatic hydrocarbons, induces a rapid reduction in steady state aryl hydrocarbon receptor (AhR). Hydrocarbons, Aromatic 85-106 aryl hydrocarbon receptor Homo sapiens 150-175 12002481-1 2002 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a prototype of environmental halogenated aromatic hydrocarbons, induces a rapid reduction in steady state aryl hydrocarbon receptor (AhR). Hydrocarbons, Aromatic 85-106 aryl hydrocarbon receptor Homo sapiens 177-180 11768231-1 2001 Aryl hydrocarbon receptor (AhR) belongs to the bHLH/PAS transcription factor family and is activated by various polycyclic or halogenated aromatic hydrocarbons, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3MC). Hydrocarbons, Aromatic 138-159 aryl hydrocarbon receptor Homo sapiens 0-25 11768231-1 2001 Aryl hydrocarbon receptor (AhR) belongs to the bHLH/PAS transcription factor family and is activated by various polycyclic or halogenated aromatic hydrocarbons, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3-methylcholanthrene (3MC). Hydrocarbons, Aromatic 138-159 aryl hydrocarbon receptor Homo sapiens 27-30 11005382-1 2000 The aryl hydrocarbon receptor (AhR) is a ligand-inducible transcription factor that mediates biological responses to halogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 129-150 aryl hydrocarbon receptor Homo sapiens 4-29 11005382-1 2000 The aryl hydrocarbon receptor (AhR) is a ligand-inducible transcription factor that mediates biological responses to halogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 129-150 aryl hydrocarbon receptor Homo sapiens 31-34 9972449-2 1998 Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated aromatic hydrocarbons whose toxicity occurs through activation of the AHR. Hydrocarbons, Aromatic 41-62 aryl hydrocarbon receptor Homo sapiens 16-19 10373624-1 1999 : Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences. Hydrocarbons, Aromatic 264-284 aryl hydrocarbon receptor Homo sapiens 113-124 10373624-1 1999 : Transcriptional up-regulation of mammalian CYP1A1 genes by dioxin is known to require binding of dioxin to the Ah receptor (AHR), subsequent interaction of this ligand-receptor complex with the AHR nuclear translocator (ARNT), and binding of this heterodimer to aromatic hydrocarbon response elements (AHREs) located in the 5" flanking sequences. Hydrocarbons, Aromatic 264-284 aryl hydrocarbon receptor Homo sapiens 126-129 9972449-2 1998 Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated aromatic hydrocarbons whose toxicity occurs through activation of the AHR. Hydrocarbons, Aromatic 41-62 aryl hydrocarbon receptor Homo sapiens 192-195 9972449-2 1998 Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated aromatic hydrocarbons whose toxicity occurs through activation of the AHR. Hydrocarbons, Aromatic 122-143 aryl hydrocarbon receptor Homo sapiens 16-19 9972449-2 1998 Ligands for the AHR include a variety of aromatic hydrocarbons, including the chlorinated dioxins and related halogenated aromatic hydrocarbons whose toxicity occurs through activation of the AHR. Hydrocarbons, Aromatic 122-143 aryl hydrocarbon receptor Homo sapiens 192-195 9765510-1 1998 The aryl hydrocarbon receptor (AHR) and its DNA binding partner, the AHR nuclear translocator (ARNT), are basic helix-loop-helix transcription factors that mediate many of the toxic and carcinogenic effects of polyhalogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 226-247 aryl hydrocarbon receptor Homo sapiens 4-29 9765510-1 1998 The aryl hydrocarbon receptor (AHR) and its DNA binding partner, the AHR nuclear translocator (ARNT), are basic helix-loop-helix transcription factors that mediate many of the toxic and carcinogenic effects of polyhalogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 226-247 aryl hydrocarbon receptor Homo sapiens 31-34 9415701-1 1997 The aryl hydrocarbon receptor (AhR) functions as a transcription factor after ligand binding by halogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 108-129 aryl hydrocarbon receptor Homo sapiens 4-29 9391097-1 1997 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause altered gene expression and toxicity. Hydrocarbons, Aromatic 105-126 aryl hydrocarbon receptor Homo sapiens 31-34 9415701-1 1997 The aryl hydrocarbon receptor (AhR) functions as a transcription factor after ligand binding by halogenated aromatic hydrocarbons. Hydrocarbons, Aromatic 108-129 aryl hydrocarbon receptor Homo sapiens 31-34 9415701-2 1997 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic halogenated aromatic hydrocarbon, is dependent on binding to the AhR to mediate a broad range of toxic effects. Hydrocarbons, Aromatic 71-91 aryl hydrocarbon receptor Homo sapiens 124-127 7821706-7 1994 These results support a role for the Ah receptor in mediating the antiestrogenic activity of polynuclear and halogenated aromatic hydrocarbons and illustrate cross-talk between the Ah and estrogen receptor signal transduction pathways. Hydrocarbons, Aromatic 121-142 aryl hydrocarbon receptor Homo sapiens 37-48 9399571-1 1997 A heterodimer of AhR (aryl hydrocarbon receptor) and Arnt (AhR nuclear translocator) conveys a transactivation signal of aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene to the genes for a group of drug-metabolizing enzymes. Hydrocarbons, Aromatic 121-142 aryl hydrocarbon receptor Homo sapiens 17-20 9399571-1 1997 A heterodimer of AhR (aryl hydrocarbon receptor) and Arnt (AhR nuclear translocator) conveys a transactivation signal of aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene to the genes for a group of drug-metabolizing enzymes. Hydrocarbons, Aromatic 121-142 aryl hydrocarbon receptor Homo sapiens 22-47 7598497-2 1995 Binding of polycyclic or halogenated aromatic hydrocarbon (PAH and HAH) ligand causes release of AHR, which then associates with the AHR nuclear translocator protein (ARNT) to generate the heterodimeric "transformed" AHRC. Hydrocarbons, Aromatic 37-57 aryl hydrocarbon receptor Homo sapiens 97-100 7494865-1 1995 The aryl hydrocarbon (Ah) receptor binds several different structural classes of chemicals, including halogenated aromatics, typified by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polynuclear aromatic and heteropolynuclear aromatic hydrocarbons. Hydrocarbons, Aromatic 224-245 aryl hydrocarbon receptor Homo sapiens 4-34 7526149-1 1994 The aryl hydrocarbon receptor nuclear translocator (Arnt) is a basic helix-loop-helix transcription factor that heterodimerizes with the aryl hydrocarbon receptor to mediate signal transduction pathways inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin and other planar aromatic hydrocarbons. Hydrocarbons, Aromatic 269-290 aryl hydrocarbon receptor Homo sapiens 4-29 8161208-1 1994 The mammalian aromatic hydrocarbon (Ah) receptor is a soluble protein involved in the regulation of gene expression by halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hydrocarbons, Aromatic 131-152 aryl hydrocarbon receptor Homo sapiens 14-48 34232800-1 2021 The etiology of multiple myeloma (MM) remains incompletely understood; however, epidemiologic studies have suggested a possible link between exposure to environmental aromatic hydrocarbons-which serve as exogenous ligands for the aryl hydrocarbon receptor (AHR), which has been implicated in cancer biology-and development of monoclonal gammopathy of undetermined significance (MGUS) and MM. Hydrocarbons, Aromatic 167-188 aryl hydrocarbon receptor Homo sapiens 230-255 1847246-7 1991 These data demonstrate the existence of Ah receptor in human tonsils and suggest that this immune organ may be an appropriate model for further studies on the mechanism and manifestation of aromatic hydrocarbon-induced immunotoxicity in man. Hydrocarbons, Aromatic 190-210 aryl hydrocarbon receptor Homo sapiens 40-51 34232800-1 2021 The etiology of multiple myeloma (MM) remains incompletely understood; however, epidemiologic studies have suggested a possible link between exposure to environmental aromatic hydrocarbons-which serve as exogenous ligands for the aryl hydrocarbon receptor (AHR), which has been implicated in cancer biology-and development of monoclonal gammopathy of undetermined significance (MGUS) and MM. Hydrocarbons, Aromatic 167-188 aryl hydrocarbon receptor Homo sapiens 257-260 32907554-5 2020 Because MT is an aromatic hydrocarbon, it may be a ligand for AHR. Hydrocarbons, Aromatic 17-37 aryl hydrocarbon receptor Homo sapiens 62-65 30393146-15 2019 Overall, the induction of CYP3Cs by AhR and ER ligands is different from mammalian CYP3A and may suggest a functional role for CYP3Cs that involves planar aromatic hydrocarbons and steroids. Hydrocarbons, Aromatic 155-176 aryl hydrocarbon receptor Homo sapiens 36-39