PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2607315-2 1989 Porphobilinogen deaminase concentration (micrograms/gHb) was quantified using a recently developed double-sandwich ELISA. 4-hydroxybutyric acid 52-55 hydroxymethylbilane synthase Homo sapiens 0-25 2607315-6 1989 The majority (91%) of gene carriers, from 25 families, had a diminished porphobilinogen deaminase concentration of 102 +/- 18 micrograms/gHb, with a slightly lowered specific activity of 634 +/- 105 nkat/g. 4-hydroxybutyric acid 137-140 hydroxymethylbilane synthase Homo sapiens 72-97 2607315-7 1989 In 9% of the gene carriers, representing six different families, an increase in porphobilinogen deaminase concentration to 269 +/- 46 micrograms/gHb, and a highly significant reduction in specific activity to 234 +/- 48 nkat/g, were found, which indicates the presence of a different mutation. 4-hydroxybutyric acid 145-148 hydroxymethylbilane synthase Homo sapiens 80-105