PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28805748-1 2017 A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1-3. benzofuran 12-22 sirtuin 1 Homo sapiens 123-128 31994471-8 2020 RESULTS: The benzofuran derivative 3m showed encouraging growth inhibition of both MDAMB-231 and MCF-7 cell lines and significant inhibition of SIRT1. benzofuran 13-23 sirtuin 1 Homo sapiens 144-149 31994471-10 2020 CONCLUSION: Our efforts not only accomplished a one-pot and direct access to 2-(het)aryl substituted benzofurans but also revealed that the benzofuran framework presented here could be a potential template for the identification of potent inhibitors of SIRT1. benzofuran 101-112 sirtuin 1 Homo sapiens 253-258 31994471-10 2020 CONCLUSION: Our efforts not only accomplished a one-pot and direct access to 2-(het)aryl substituted benzofurans but also revealed that the benzofuran framework presented here could be a potential template for the identification of potent inhibitors of SIRT1. benzofuran 101-111 sirtuin 1 Homo sapiens 253-258