PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17827777-1	2007	comparison of furanocoumarin, coumarin, and benzofuran dimers as potent inhibitors of CYP3A4 activity.	benzofuran	44-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92	
17827777-5	2007	We prepared a series of furanocoumarin, coumarin, and benzofuran derivatives that have inhibitory effects on the activity of human CYP3A4.	benzofuran	54-64	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137	
17827777-6	2007	A synthetic benzofuran dimer, which is more accessible than furanocoumarin dimers, exhibited activity against CYP3A4 comparable to that of furanocoumarin dimers.	benzofuran	12-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-116	
35510231-7	2022	Taken together, our preliminary investigations suggested that the rational deuteration of dronedarone at its benzofuran ring reduces aberrant cytochrome P450 3A4/5-mediated bioactivation, which attenuated its mitochondrial toxicity in human hepatic HepG2 cells.	benzofuran	109-119	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-163