PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23956983-5 2013 The kinetic and crystallographic data acquired with mutant enzymes permit us to infer that conversion of gem-diamine to external aldimine is significantly slowed because intermediates are trapped into an anomalous position by a misorientation of the PLP ring, and a new energy barrier hampers the transaldimination reaction. gem-diamine 105-116 myelin proteolipid protein Oryctolagus cuniculus 250-253