PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20876747-1 2011 Lobeline attenuates the behavioral effects of methamphetamine via inhibition of the vesicular monoamine transporter (VMAT2). Lobeline 0-8 solute carrier family 18 member A2 Homo sapiens 117-122 18191815-3 2008 Lobeline caused release of [(3)H]dopamine to a similar extent as reserpine (VMAT-2 inhibitor), but was less efficacious than methamphetamine or dopamine. Lobeline 0-8 solute carrier family 18 member A2 Homo sapiens 76-82 18191815-5 2008 These results suggest that lobeline has unique properties at the DAT and VMAT-2 which may make it useful as a pharmacotherapeutic to treat methamphetamine abuse. Lobeline 27-35 solute carrier family 18 member A2 Homo sapiens 73-79 15121762-10 2004 Lobelane and ketoalkene were 5-fold more potent (Ki = 0.92 and 1.35 microM, respectively) than lobeline (Ki = 5.46 microM) in inhibiting [3H]methoxytetrabenazine binding to VMAT2 in vesicle preparations. Lobeline 95-103 solute carrier family 18 member A2 Homo sapiens 173-178 19855096-2 2010 Lobeline interacts with nicotinic receptor subtypes, dopamine transporters (DATs), and vesicular monoamine transporters (VMAT2s). Lobeline 0-8 solute carrier family 18 member A2 Homo sapiens 121-126 16107155-1 2005 (-)-Lobeline (2R,6S,10S), an antagonist at nicotinic acetylcholine receptors (nAChRs), inhibits the neurochemical and behavioral effects of methamphetamine and inhibits dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) function. Lobeline 0-12 solute carrier family 18 member A2 Homo sapiens 233-238 16107155-6 2005 Generally, all of these analogues had lower affinities at alpha4beta2 and alpha7 nAChRs compared to lobeline, thereby increasing selectivity for VMAT2. Lobeline 100-108 solute carrier family 18 member A2 Homo sapiens 145-150 15102929-5 2004 High concentrations of lobeline induced a statistically significant release of [3H]DA from HEK-hDAT-hVMAT2 cells, but only in the absence of DHTB, suggesting an hVMAT2-mediated effect. Lobeline 23-31 solute carrier family 18 member A2 Homo sapiens 100-106 15102929-5 2004 High concentrations of lobeline induced a statistically significant release of [3H]DA from HEK-hDAT-hVMAT2 cells, but only in the absence of DHTB, suggesting an hVMAT2-mediated effect. Lobeline 23-31 solute carrier family 18 member A2 Homo sapiens 161-167