PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2864237-5 1985 Concomitant treatment of testicular cells with nicotinic cholinergic agonists (lobeline, nicotine, and dimethylphenylpiperazinium iodide) inhibited hCG-stimulated androgen biosynthesis in a dose-dependent fashion, with IC50 values of 3 X 10(-5), 1.7 X 10(-4), and greater than 10(-3) M, respectively. Lobeline 79-87 hypertrichosis 2 (generalised, congenital) Homo sapiens 148-151 2864237-7 1985 Lobeline (10-4) M) decreased hCG-stimulated testosterone production (50-75%) throughout the 2-day culture period; however, this inhibition was reversible upon removal of the drug. Lobeline 0-8 hypertrichosis 2 (generalised, congenital) Homo sapiens 29-32 2864237-8 1985 Lobeline also inhibited hCG-stimulated cAMP accumulation as well as testosterone production induced by cholera toxin (65% inhibition), forskolin (50% inhibition), or (Bu)2cAMP (70% inhibition). Lobeline 0-8 hypertrichosis 2 (generalised, congenital) Homo sapiens 24-27