PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8023938-6	1994	In the presence of HCO3(-)-CO2, a 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)-sensitive, Na-, Cl-, and HCO3(-)-dependent acid extrusion mechanism accounted for approximately 60% of pHi recovery from acidic pHi; this mechanism is most consistent with the presence of a Na-dependent Cl-HCO3- exchanger (Na+HCO3(-)-Cl-H+).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	34-82	glucose-6-phosphate isomerase 1	Mus musculus	193-196	
9814856-5	1998	Suramin and 4,4"-diisothiocyano-2,2"-stilbene-disulfonic acid (DIDS) inhibit the biphasic change in pHi, apparently by acting as antagonists at P2 receptors.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	12-61	glucose-6-phosphate isomerase 1	Mus musculus	100-103	
9814856-5	1998	Suramin and 4,4"-diisothiocyano-2,2"-stilbene-disulfonic acid (DIDS) inhibit the biphasic change in pHi, apparently by acting as antagonists at P2 receptors.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	63-67	glucose-6-phosphate isomerase 1	Mus musculus	100-103	
9514197-3	1998	In the presence of EIPA and/or 4",4"-diisothiocyano-stilbene-2",2"-sulfonic acid (DIDS), an inhibitor of Na+-coupled anion exchangers and Na+-HCO3- cotransport, a slow decline of pHi was seen.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	82-86	glucose-6-phosphate isomerase 1	Mus musculus	179-182	
9514197-4	1998	Following intracellular acidification imposed by an NH4Cl prepulse, pHi recovered at a rapid rate, which was reduced by reduction of [Na+]o and was virtually abolished by EIPA and DIDS in combination.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	180-184	glucose-6-phosphate isomerase 1	Mus musculus	68-71	
9514197-8	1998	Together, this points toward a combined role of DIDS-insensitive Cl-/HCO3- and passive H+ influx in the recovery of pHi after alkalinization.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	48-52	glucose-6-phosphate isomerase 1	Mus musculus	116-119	
11087070-9	2000	These findings lead us to propose a working hypothesis that DIDS mainly induces superoxide production accompanied by decreasing pHi mediated through a Ca2+ -dependent effect on the mitochondria rather than on NADPH oxidase.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	60-64	glucose-6-phosphate isomerase 1	Mus musculus	128-131	
7713887-6	1995	In the presence of 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS; inhibitor of HCO3-/Cl- exchange), the effect of glucose on pHi in HCO3- buffer became similar to that in HEPES buffer.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	19-67	glucose-6-phosphate isomerase 1	Mus musculus	134-137	
8023938-6	1994	In the presence of HCO3(-)-CO2, a 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)-sensitive, Na-, Cl-, and HCO3(-)-dependent acid extrusion mechanism accounted for approximately 60% of pHi recovery from acidic pHi; this mechanism is most consistent with the presence of a Na-dependent Cl-HCO3- exchanger (Na+HCO3(-)-Cl-H+).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	34-82	glucose-6-phosphate isomerase 1	Mus musculus	218-221	
8023938-6	1994	In the presence of HCO3(-)-CO2, a 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)-sensitive, Na-, Cl-, and HCO3(-)-dependent acid extrusion mechanism accounted for approximately 60% of pHi recovery from acidic pHi; this mechanism is most consistent with the presence of a Na-dependent Cl-HCO3- exchanger (Na+HCO3(-)-Cl-H+).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	84-88	glucose-6-phosphate isomerase 1	Mus musculus	193-196	
8023938-6	1994	In the presence of HCO3(-)-CO2, a 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)-sensitive, Na-, Cl-, and HCO3(-)-dependent acid extrusion mechanism accounted for approximately 60% of pHi recovery from acidic pHi; this mechanism is most consistent with the presence of a Na-dependent Cl-HCO3- exchanger (Na+HCO3(-)-Cl-H+).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	84-88	glucose-6-phosphate isomerase 1	Mus musculus	218-221	
2844806-4	1988	This rise in pHi is both Na+- and HCO3- -dependent, does not occur in Cl(-)-depleted cells, and is inhibited by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid, but not by 5-(n,n-dimethyl)-amiloride, indicating the involvement of Na+-dependent HCO3-/Cl- exchange.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	112-160	glucose-6-phosphate isomerase 1	Mus musculus	13-16	
1503904-2	1992	Cell killing is enhanced when these agents are used in combination with compounds (amiloride, 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)) which inhibit the membrane-based exchangers responsible for the regulation of intracellular pH (pHi).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	94-142	glucose-6-phosphate isomerase 1	Mus musculus	247-250	
1503904-2	1992	Cell killing is enhanced when these agents are used in combination with compounds (amiloride, 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)) which inhibit the membrane-based exchangers responsible for the regulation of intracellular pH (pHi).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	144-148	glucose-6-phosphate isomerase 1	Mus musculus	247-250	
2107748-5	1990	Steady-state pHi of BC3H-1 cells in NHB acidified reversibly on exposure to 0.5 mM 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS; 1.4 +/- 0.3 x 10(-4) pH/s), 1 mM amiloride (2.0 +/- 0.7 x 10(-4) pH/s), or Na-free solution (8.3 +/- 2.4 x 10(-4) pH/s) and alkalinized upon exposure to Cl-free solutions (9.7 +/- 2.2 x 10(-4) pH/s).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	83-131	glucose-6-phosphate isomerase 1	Mus musculus	13-16	
2107748-5	1990	Steady-state pHi of BC3H-1 cells in NHB acidified reversibly on exposure to 0.5 mM 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS; 1.4 +/- 0.3 x 10(-4) pH/s), 1 mM amiloride (2.0 +/- 0.7 x 10(-4) pH/s), or Na-free solution (8.3 +/- 2.4 x 10(-4) pH/s) and alkalinized upon exposure to Cl-free solutions (9.7 +/- 2.2 x 10(-4) pH/s).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	133-137	glucose-6-phosphate isomerase 1	Mus musculus	13-16	
2107748-7	1990	This new steady-state pHi acidified very slowly upon exposure to 1 mM amiloride (0.3 +/- 0.1 x 10(-4) pH/s), acidified more rapidly upon exposure to 0.5 mM DIDS (5.9 +/- 0.6 x 10(-4) pH/s) or Na-free solutions (9.8 +/- 1.0 x 10(-4) pH/s), and alkalinized on exposure to Cl-free solutions (24.5 +/- 1.3 x 10(-4) pH/s).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	156-160	glucose-6-phosphate isomerase 1	Mus musculus	22-25	
2844806-5	1988	Furthermore, the recovery of pHi from acute acid loads is accelerated by HCO3- in a Na+-dependent and 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid-sensitive manner and is blocked in Cl(-) -depleted cells.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	102-150	glucose-6-phosphate isomerase 1	Mus musculus	29-32	
2835488-7	1988	Pretreatment with DIDS (0.2 mM) did not change the pHi of the nonstimulated conditions; however, it significantly enhanced the increase in pHi induced by ACh.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	18-22	glucose-6-phosphate isomerase 1	Mus musculus	139-142	
25572649-8	2015	DIDS significantly reduced the rise in pHi caused by Cl(-) removal in all embryos; the finding pointed out that this pHi changes are due to AE activity.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	0-4	glucose-6-phosphate isomerase 1	Mus musculus	39-42	
25572649-8	2015	DIDS significantly reduced the rise in pHi caused by Cl(-) removal in all embryos; the finding pointed out that this pHi changes are due to AE activity.	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	0-4	glucose-6-phosphate isomerase 1	Mus musculus	117-120	
17003225-6	2007	The inhibitory effect of DIDS suggests that the acidification of pH(i) and the alkalinization of pH(e) induced by hypotonicity in wild-type cells could be due to an exit of HCO(3)(-).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	25-29	glucose-6-phosphate isomerase 1	Mus musculus	65-70	
11171615-6	2001	DIDS or removal of extracellular Cl(-) increased pH(i), whereas an acidification was observed on removal of Na(+) or both Na(+) and Cl(-).	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	0-4	glucose-6-phosphate isomerase 1	Mus musculus	49-54